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Modified cellulose particles, and preparation method and application thereof

A cellulose and particle technology, applied in the field of medical materials, can solve problems such as complex methods, and achieve the effects of simple preparation method, controllable particle size, and broad application prospects

Pending Publication Date: 2020-01-24
GUANGXI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The Chinese patent with the application number 201210334217.7 discloses a porous cellulose microsphere adsorbent for hemoperfusion and its preparation method. The prepared porous cellulose microspheres have a particle size of 0.1-2 mm, and the inner pores of the cellulose microspheres are The size is mainly distributed in 5nm~40nm, the specific surface area is 400~1000m2 / g, and the operating pressure is 7~15bar. Porous cellulose microspheres with a pressure of 7-15 bar can be used as a carrier for biomedical materials or as an adsorbent material for hemoperfusion, but the method is relatively complicated

Method used

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  • Modified cellulose particles, and preparation method and application thereof
  • Modified cellulose particles, and preparation method and application thereof
  • Modified cellulose particles, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Suspend 2g of cellulose particles (CB) in 20ml of dimethyl sulfoxide (DMSO), add 1.6g of carbonyldiimidazole (CDI), stir at room temperature for 2-4 hours, then add 8 ml of hydrazine hydrate solution dropwise, and continue the reaction 12 hours. After terminating the reaction, dilute the reaction system with water and dialyze with a dialysis bag (2000-4000kD) for 2-4 days. Store after freeze-drying to obtain modified cellulose particles.

Embodiment 2

[0029] Suspend 4 g of cellulose particles (CB) in 40 ml of dimethyl sulfoxide (DMSO), add 6 g of carbonyldiimidazole (CDI), stir at room temperature for 3 hours, then add 15 ml of hydrazine hydrate solution dropwise, and continue the reaction for 18 hours . After terminating the reaction, dilute the reaction system with water and dialyze with a dialysis bag (2000-4000kD) for 2-4 days. Store after freeze-drying.

Embodiment 3

[0031] Suspend 5 g of cellulose particles (CB) in 50 ml of dimethyl sulfoxide (DMSO), add 5 g of carbonyldiimidazole (CDI), stir at room temperature for 4 hours, then add 18 ml of hydrazine hydrate solution dropwise, and continue the reaction for 24 hours . After terminating the reaction, dilute the reaction system with water and dialyze with a dialysis bag (2000-4000kD) for 2-4 days. Store after freeze-drying.

[0032] In the above examples, the purity of dimethyl sulfoxide is more than or equal to 99.9%, and the purity of carbonyldiimidazole is more than or equal to 97.0%.

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Abstract

A modified cellulose particle is characterized in that the modified cellulose particle is a hydrazide-based functionalized cellulose particle. A preparation method of the modified cellulose particle comprises the following steps: suspending cellulose particles in a proper amount of dimethyl sulfoxide, adding carbonyl diimidazole with the mass 0.8-1.5 times of the mass of the cellulose particles, performing stirring at room temperature for 2-4 h, dropwise adding an excessive hydrazine hydrate solution, and performing a continuous reaction for 12-24 h; and, diluting the reaction system with deionized water after the reaction is ended, performing dialysis for 2-4 d with a dialysis bag, and performing freeze-drying and storage. The modified cellulose particle is applied to a blood perfusion device to remove carbonylated proteins, and has a wide application prospect in adjuvant therapy of senile diseases.

Description

technical field [0001] The invention belongs to the field of medical materials, in particular to a modified cellulose particle. Background technique [0002] With the advent of an aging society, the incidence of diseases related to age and aging is increasing. Existing studies have shown that active carbonyls are involved in a variety of age-related diseases (such as arthritis, renal failure, cardiovascular disease, Parkinson's disease, Alzheimer's disease, cancer, diabetes, chronic obstructive pulmonary disease etc.) and the initiation and development process of stress, and even directly participate in and initiate the aging process. Therefore, the carbonyl stress theory of aging holds that carbonyl stress is one of the core biochemical processes of biological aging. Carbonyl stress refers to the fact that the production of active carbonyl substances in biological systems exceeds the ability to remove them, which leads to carbonylation of biomacromolecules such as protein...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/30
CPCB01J20/26
Inventor 郑立高明冯娴婧胡文文
Owner GUANGXI MEDICAL UNIVERSITY
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