Unlock instant, AI-driven research and patent intelligence for your innovation.

Preparation method of polyacrylonitrile/polyaniline/nickel nanofiber membrane applied to artificial nerve conduit

A nanofiber membrane, polyacrylonitrile technology, applied in rayon manufacturing, fiber processing, fiber chemical characteristics, etc., can solve the problems of poor conductivity of nanomaterials, uneven distribution of nanofibers, poor strength of nanofibers, etc. Favorable for adhesion and proliferation, fast and simple production, low cost effect

Active Publication Date: 2019-11-05
WUHAN UNIV OF TECH
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Polyaniline (PANI) not only has the electrical conductivity of metals and the processability of plastics, but also has chemical and electrochemical properties that metals and plastics lack, but it has high requirements for solvents, and the resulting nanofibers have poor strength and brittleness. Big
There are few reports on the electrospinning of polyacrylonitrile (PAN) mixed with polyaniline (PANI). The current method is generally to electrospin pure polyacrylonitrile (PAN) first, and then use oxidative polymerization or in-situ polymerization to make the polyacrylonitrile (PAN) Polyaniline (PANI) is deposited on the surface of acrylonitrile (PAN) nanofibers, the conductivity of the prepared nanomaterials is not ideal, and the distribution of nanofibers is uneven

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of polyacrylonitrile/polyaniline/nickel nanofiber membrane applied to artificial nerve conduit
  • Preparation method of polyacrylonitrile/polyaniline/nickel nanofiber membrane applied to artificial nerve conduit
  • Preparation method of polyacrylonitrile/polyaniline/nickel nanofiber membrane applied to artificial nerve conduit

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) Construction of electrospinning machine

[0030] Connect the high-voltage power supply, micro-injection pump, reciprocating mobile platform and drum receiver in order, put the micro-injection pump on the reciprocating platform, and fix it, reciprocate with the reciprocating platform, connect the ground wire, and turn on the power supply. debug the machine;

[0031] (2) Preparation of spinning solution

[0032] Weigh 2.5g of PAN and 7.5g of PANI into the bottle, then add 10ml of DMF solution into the bottle, place it on a magnetic stirrer and stir it overnight, then add 0.1g of nickel powder, and place the bottle in an ultrasonic cleaner for 1 hour;

[0033] The needle type of the syringe used is 18G, and the operating parameters are:

[0034]

[0035] (3) Electrospinning

[0036] Inhale the prepared spinning solution into the syringe, then install the syringe on the syringe pump, place the syringe pump on the reciprocating platform, paste tin foil on the drum ...

Embodiment 2

[0040] (1) Construction of electrospinning machine

[0041] Connect the high-voltage power supply, micro-injection pump, reciprocating mobile platform and drum receiver in order, put the micro-injection pump on the reciprocating platform, and fix it, reciprocate with the reciprocating platform, connect the ground wire, and turn on the power supply. debug the machine;

[0042] (2) Preparation of spinning solution

[0043] Weigh 5g of PAN and 10g of PANI in a bottle, then add 10ml of DMF solution into the bottle, place it on a magnetic stirrer and stir it overnight, then add 1g of nickel powder, and place the bottle in an ultrasonic cleaner for 1 hour;

[0044] The needle type of the syringe used is 18G, and the operating parameters are:

[0045]

[0046] (3) Electrospinning

[0047] Inhale the prepared spinning solution into the syringe, then install the syringe on the syringe pump, place the syringe pump on the reciprocating platform, paste tin foil on the drum receiver,...

Embodiment 3

[0059] The preparation method is the same as in Example 1, the amount of PANI is adjusted to be 2 to 10, and the electrical conductivity of the polyacrylonitrile / polyaniline / nickel nanofiber membrane obtained is tested, and the results are as follows Figure 4 shown. It can be seen that when the amount of PAN and DMF added is constant, the conductivity of the fiber membrane increases with the increase of PANi, but with the increase of the amount of PANI added, the viscosity of the resulting spinning solution increases gradually, and when the amount of PANI added is 10g , has been difficult to achieve spinning.

[0060] In this application, by optimizing the ratio of PAN, PANI and Ni, a nanofiber membrane that is easy to spin and has good electrical conductivity is obtained.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a method for easily and quickly producing a polyacrylonitrile / polyaniline / nickel nanofiber membrane applied to preparation of an artificial nerve conduit. The method comprises the steps that polyacrylonitrile and polyaniline are weighed in a bottle, an N,N-dimethyl formamide solution is added, sufficient stirring is conducted, so that the solution is dissolved, nickel powderis added, even ultrasonic treatment is conducted, and a spinning solution is obtained; the spinning solution is sucked into an injector, then the injector is installed on an injection pump, the injection pump is fixed to a reciprocating motion platform, tinfoil is pasted to a revolving drum receiver, a spinning machine and a power supply of the reciprocating motion platform are connected for spinning, and the static spinning nano fiber membrane is obtained. The method has the advantages of being easy to implement, low in cost, mild in condition, environmentally friendly and the like. By detecting the cell toxicity through an MTT agent, it is indicated that the nanofiber membrane does not have cell toxicity, that is to say, the cell compatibility is good. It is indicated through a CCK-8 experiment that the nanofiber membrane can be well beneficial to adhesion and proliferation of nerve cells.

Description

technical field [0001] The invention relates to a simple and fast method for producing polyacrylonitrile / polyaniline / nickel nanofiber membranes that can be used for preparing artificial nerve guides. Background technique [0002] The development of new materials is a priority area of ​​development in the 21st century. Electrospinning technology has been widely used in the field of preparing nanofibers in recent years. It can prepare many different types of nanofibers, especially in the preparation of composite nanofibers. It has achieved remarkable results and is one of the most effective methods for preparing nanofibers. This new technology for producing nanofibers will play a huge role in the fields of biomedical materials, high-temperature filtration, high-efficiency catalysis, photoelectric devices, and energy. Due to its complex structure and function, peripheral nerve tissue has a high disability rate, poor prognosis and complicated treatment once it is damaged, which...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): D04H1/4382D04H1/728D01D5/00D01F1/10D01F8/08D01F8/16
CPCD04H1/4382D04H1/728D01D5/003D01D5/0069D01D5/0061D01D5/0092D01F8/08D01F8/16D01F1/10
Inventor 张甜王马约皮埃尔施晓晨
Owner WUHAN UNIV OF TECH