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Antibacterial/antifogging coating based on N-hydroxyethyl acrylamide and preparation method thereof

A technology of hydroxyethylacrylamide and anti-fog coatings, which can be applied in coatings, antifouling/underwater coatings, polyurea/polyurethane coatings, etc., can solve problems such as infection, and achieve good water resistance, high transparency, The effect of simple preparation process

Active Publication Date: 2019-11-12
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Based on the hydration of N-hydroxyethylacrylamide, the good bactericidal performance of quaternary ammonium salt, and the hydrophobicity of fluorine-containing methacrylate, the present invention constructs a comprehensive anti-bacterial adhesion, bactericidal and anti-fog function. Type surface, this kind of surface is expected to be used on the lens of medical endoscope to solve the problem of bacterial infection and atomization during use, and related content has been rarely reported so far

Method used

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  • Antibacterial/antifogging coating based on N-hydroxyethyl acrylamide and preparation method thereof
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  • Antibacterial/antifogging coating based on N-hydroxyethyl acrylamide and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) Synthesis of poly(N-hydroxyethylacrylamide-co-methacryloyloxyethyl dimethyl butyl ammonium bromide-co-trifluoroethyl methacrylate):

[0033] Weigh N-hydroxyethylacrylamide, methacryloyloxyethyldimethylbutylammonium bromide and trifluoroethyl methacrylate in a molar ratio of 300:150:50, and dissolve them in tetrahydrofuran in a homogeneous solution with a concentration of 30%, then add azobisisobutyronitrile of 0.5wt% of the total mass of the monomers to it, and place it in an oil bath at 65°C for 8 hours. After the reaction, dialysis is performed at room temperature Freeze-dried for 24 hours to obtain poly(N-hydroxyethylacrylamide-co-methacryloyloxyethyl dimethyl butyl ammonium bromide-co-trifluoroethyl methacrylate), whose structural formula is:

[0034]

[0035] (2) Preparation of antibacterial / anti-fog coating based on N-hydroxyethylacrylamide:

[0036] Poly(N-hydroxyethylacrylamide-co-methacryloyloxyethyldimethylbutylammonium bromide-co-trifluoroethyl methac...

Embodiment 2

[0043] (1) Synthesis of poly(N-hydroxyethylacrylamide-co-methacryloyloxyethyltrimethylammonium bromide-co-trifluoroethyl methacrylate):

[0044]Weigh N-hydroxyethylacrylamide, methacryloyloxyethyltrimethylammonium bromide and trifluoroethyl methacrylate in a molar ratio of 200:100:30, and dissolve them in tetrahydrofuran. Prepare a uniform solution with a concentration of 20%, then add 0.5wt% azobisisobutyronitrile to the total monomer mass, place it in an oil bath at 60°C for 10 hours, dialyze it after the reaction, and freeze it at room temperature Dry for 24 hours to obtain poly(N-hydroxyethylacrylamide-co-methacryloyloxyethyltrimethylammonium bromide-co-trifluoroethyl methacrylate), whose structural formula is:

[0045]

[0046] (2) Preparation of antibacterial / anti-fog coating based on N-hydroxyethylacrylamide:

[0047] Poly(N-hydroxyethylacrylamide-co-methacryloyloxyethyltrimethylammonium bromide-co-trifluoroethyl methacrylate): 10%;

[0048] Hexamethylene diisocyan...

Embodiment 3

[0054] (1) Synthesis of poly(N-hydroxyethylacrylamide-co-methacryloyloxyethyl dimethylundecyl ammonium bromide-co-hexafluorobutyl methacrylate):

[0055] Weigh three monomers of N-hydroxyethylacrylamide, methacryloyloxyethyl dimethylundecylammonium bromide and hexafluorobutyl methacrylate in a molar ratio of 400:200:40, dissolve Prepare a homogeneous solution with a concentration of 50% in tetrahydrofuran, then add 0.5 wt% of azobisisobutyronitrile to the total monomer mass, place it in an oil bath at 70°C for 9 hours, and dialyze , lyophilized at room temperature for 24 hours to obtain poly(N-hydroxyethylacrylamide-co-methacryloyloxyethyldimethylundecylammonium bromide-co-hexafluorobutyl methacrylate), which The structural formula is:

[0056]

[0057] (2) Preparation of antibacterial / anti-fog coating based on N-hydroxyethylacrylamide:

[0058] Poly(N-hydroxyethylacrylamide-co-methacryloyloxyethyldimethylundecylammonium bromide-co-hexafluorobutyl methacrylate): 2%;

[0...

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Abstract

The invention discloses an antibacterial / antifogging coating based on N-hydroxyethyl acrylamide and a preparation method thereof. Firstly, a random copolymer of the N-hydroxyethyl acrylamide, a quaternary ammonium salt and perfluoroalkyl methacrylate is synthesized through free radical polymerization, and then the random copolymer is thermo-crosslinked with a hexamethylene diisocyanate trimer under catalysis of dibutyltin dilaurate to form a film. The N-hydroxyethyl acrylamide with high hydratability and the positively-charged quaternary ammonium salt enable the coating to have the propertiesof bacterial adhesion resistance and sterilization, synergistic bacterial resistance is achieved, and the N-hydroxyethyl acrylamide with the high hydratability and the positively-charged quaternary ammonium salt both contain hydrophile groups so that the coating can be made to have the good antifogging property; the stability of the coating is improved advantageously through introduction of the perfluoroalkyl methacrylate; and the prepared coating is good in water resistance and high in transparency, can be used for the surfaces of various base materials, shows the good antibacterial propertyand antifogging property, and thus has practical application value in the field of medical devices.

Description

technical field [0001] The invention belongs to the field of polymer material coatings, and in particular relates to an antibacterial / antifogging coating based on N-hydroxyethylacrylamide and a preparation method thereof. Background technique [0002] Because the iatrogenic infection caused by the adhesion of bacteria on the surface of medical devices has seriously threatened human life, health and safety, it is of great significance to endow the surface of materials with antibacterial properties. Current common antimicrobial strategies mainly focus on killing surface-adhered bacteria, but ignore the problem of persistent contamination caused by the accumulation of dead bacteria / debris. Constructing a sterilizing and "degerming" comprehensive antibacterial surface can significantly improve the antibacterial effect and effectively solve the problem of dead bacteria residues. In addition, for transparent materials such as endoscope lenses, fogging is another problem during us...

Claims

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Application Information

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IPC IPC(8): C09D175/12C09D5/16C09D5/14C08G18/79C08G18/62C08F220/58C08F220/34C08F220/24
CPCC08F220/58C08G18/6266C08G18/6279C08G18/6283C08G18/792C09D5/14C09D5/1662C09D175/12C08F220/34C08F220/24
Inventor 李晓晖白珊袁晓燕任丽霞赵蕴慧
Owner TIANJIN UNIV
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