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Preparation method of graphene-filled hydrogel ultrasonic coupling patch

An ultrasonic coupling and coupling patch technology, which is applied in the fields of medical ultrasonic coupling materials and ultrasonic coupling diagnosis, can solve the problems of patient cross-infection, isolation, and patient skin cross-infection, and achieves a simple preparation method, a small attenuation coefficient, and is suitable for large-scale production effect

Inactive Publication Date: 2019-11-19
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The ultrasound probe directly contacts the patient's skin. Most doctors will start the next examination without strict disinfection after examining the patient. Especially in the case of large and medium-sized cities in my country, there are often bacteria and germs in unsterilized probes during clinical use. Easy to cause skin cross-infection between patients
According to relevant regulations, all diagnostic and therapeutic instruments that touch the skin must be effectively disinfected. Ultrasonic probes have a high risk of infection. Water used as a couplant solvent cannot completely isolate the probe from the body testing site. After the test is completed, wipe off the residual liquid directly with toilet paper. Couplant, to some extent may cause cross infection between patients

Method used

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  • Preparation method of graphene-filled hydrogel ultrasonic coupling patch
  • Preparation method of graphene-filled hydrogel ultrasonic coupling patch
  • Preparation method of graphene-filled hydrogel ultrasonic coupling patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A solid coupling patch, prepared according to the following steps:

[0022] Take 1 gram of sodium alginate, 1 gram of carrageenan, 0.05 gram of xanthan gum, 0.2 gram of sucrose ester, 2 gram of glycerin, 2 gram of PEG400, and 0.05 gram of preservative, mix evenly, add 93.7 grams of deionized water, and stir evenly to form Put the liquid mixture into a preheated emulsifier and heat and stir for 30 minutes to make an emulsion. After vacuum degassing and defoaming for 5 minutes, introduce it into the abrasive disc, and add 3% calcium chloride solution. After reacting for 2 minutes, rinse with distilled water, dry at room temperature, tear off the film and place it in a precision constant temperature incubator to balance for 72 hours. Cut the membrane according to the desired shape and size of the ultrasound probe.

Embodiment 2

[0024] A graphene-filled solid coupling patch, prepared according to the following steps:

[0025] Take 1 gram of sodium alginate, 1 gram of carrageenan, 0.05 gram of xanthan gum, 0.2 gram of sucrose ester, 2 gram of glycerin, 2 gram of PEG400, and 0.05 gram of preservative, mix evenly, add 5 mL of 1 mg / mL graphene oxide aqueous solution, add Add 88.7 grams of deionized water, stir evenly to form a liquid mixture, put it into a preheated emulsifier, heat and stir for 30 minutes to make an emulsion, vacuum degass and defoam for 5 minutes, then import it into the abrasive disc, add 3% chlorine calcium solution. After reacting for 2 minutes, rinse with distilled water, dry at room temperature, tear off the film and place it in a precision constant temperature incubator to balance for 72 hours. Cut the membrane according to the desired shape and size of the ultrasound probe.

Embodiment 3

[0027] A graphene-filled solid coupling patch, prepared according to the following steps:

[0028] Take 1 gram of sodium alginate, 1 gram of carrageenan, 0.05 gram of xanthan gum, 0.2 gram of sucrose ester, 2 gram of glycerin, 2 gram of PEG400, and 0.05 gram of preservative, mix evenly, add 10 mL of 1 mg / mL graphene oxide aqueous solution, add Add 83.7 grams of deionized water, stir evenly to form a liquid mixture, put it into a preheated emulsifier, heat and stir for 30 minutes to make an emulsion, vacuum degass and defoam for 5 minutes, then import it into the abrasive disc, add 3% chlorine calcium solution. After reacting for 2 minutes, rinse with distilled water, dry at room temperature, tear off the film and place it in a precision constant temperature incubator to balance for 72 hours. Cut the membrane according to the desired shape and size of the ultrasound probe.

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Abstract

The invention relates to a preparation method of a graphene-filled hydrogel ultrasonic coupling patch; in particular, sodium alginate and carrageenan are used as main components of patch hydrogel, glycerol and polyethylene glycol 400 are added as regulators, sucrose ester is used as an emulsifier, a calcium chloride solution is added, and a transparent hydrogel as a skeleton is formed after reaction. By addition of graphene oxide or water-soluble graphene dispersion liquid, the transparent and yellow brown hydrogel is formed according to the size of a die and is used in the field of ultrasoniccoupling diagnosis.

Description

technical field [0001] The invention relates to a method in the technical field of medical ultrasonic coupling materials. After adding graphene oxide or water-soluble graphene dispersion liquid, a transparent, yellow-brown hydrogel is formed according to the size of the mold, which is used in the field of ultrasonic coupling diagnosis. [0002] technical background [0003] During ultrasonic diagnosis, when the ultrasonic wave is incident on the interface of two different media, the greater the impedance of the two, the less the sound energy will pass through the interface and continue to another medium. When the ultrasonic diagnostic instrument is in direct contact with the skin, the presence of air will As a result, ultrasound cannot reach and enter the human body. Sound waves cannot travel effectively through air at the ultrasonic frequencies commonly used in nondestructive testing. In addition to the attenuation of the air, the acoustic impedance of the air does not matc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22
CPCA61K49/222
Inventor 严一楠杨迪诚王杰林金彩虹
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH