Preparation method of magnetic polymer microsphere

A technology of polymer microspheres and seeds, which is applied to the preparation of microspheres, the magnetism of organic materials/organic magnetic materials, microcapsule preparations, etc., and can solve the problems of long reaction cycle, low production efficiency, and small particle impurities of magnetic polymer microspheres. and other problems, to achieve the effect of improving the uniformity of particle size, increasing the yield, and shortening the time

Inactive Publication Date: 2019-11-29
无锡迈科为生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, this synthesis method not only has uncontrollable particle size of magnetic polymer microspheres, but also has poor uniformity.
Moreover, there are many uncontrollable factors in the preparation process, there will be many small particles of impurities in the magnetic polymer microspheres, and the yield is low.
Moreover, the reaction cycle is long, the production efficiency is low, it is not conducive to large-scale production, and the production stability needs to be improved.

Method used

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  • Preparation method of magnetic polymer microsphere
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preparation example Construction

[0027] The embodiment of the present invention provides a preparation method of magnetic polymer microspheres, the preparation method comprising:

[0028] Add the polymer seeds into the aqueous solution containing the stabilizer and the initiator, and stir evenly to form a uniformly dispersed seed suspension;

[0029] Mix ferric oleate and monomer evenly to form ferric oleate monomer solution;

[0030] Forming uniform droplets of the iron oleate monomer solution through a nozzle into the seed suspension, the seeds absorb the droplets and grow and polymerize in one step to obtain iron oleate polymer microspheres;

[0031] Raise the temperature to decompose the iron oleate to obtain magnetic polymer microspheres.

[0032] Ferric oleate can be used and produced on the spot, and the specific preparation method of ferric oleate is well known to those skilled in the art. Preferably, ferric oleate can be prepared by the following method: soluble Fe 3+ Add salt and sodium oleate in...

Embodiment 1

[0048] Preparation of ferric oleate: Add soluble ferric chloride and sodium oleate into a mixture of 75% ethanol solution and n-hexane, heat and stir, filter, and vacuum dry to obtain ferric oleate.

[0049] Put 2g polyvinylpyrrolidone and 0.5g benzoyl peroxide in the first container that 600g deionized water is housed, stir evenly, add 56g polystyrene seed (its particle size is 0.8 micron, CV=3%), stir Homogenize to form a uniformly dispersed seed suspension and set aside.

[0050] Add 290g iron oleate and 206g ethyl acrylate into the second container, stir evenly to form iron oleate monomer solution, set aside. A nozzle with a hole diameter of 10 μm was installed on the second container. Apply a preset pressure of 2.15MPa to the second container, maintain a temperature environment of 97°C, disperse the iron oleate monomer solution into the seed suspension within 10 minutes in the form of droplets through the nozzle, and react for 110 minutes after spraying to obtain oil Ac...

Embodiment 2

[0054] Put 3.5g polyvinylpyrrolidone and 2.5g benzoyl peroxide in the first container that 1200g deionized water is housed, stir well, add 132g polystyrene seed (its particle size is 100nm, CV=2.8%), stir Homogenize to form a uniformly dispersed seed suspension and set aside.

[0055] Add 392g iron oleate and 398g styrene monomer into the second container, stir evenly to form iron oleate monomer solution, set aside. A nozzle was installed on the second container, and the nozzle had a hole diameter of 30 μm. Apply a preset pressure of 2.15MPa to the second container, maintain a temperature environment of 90°C, disperse the ferric oleate monomer solution into the seed suspension within 20 minutes in the form of droplets through the nozzle, and react for 100 minutes after spraying to obtain oil Iron acid polymer microspheres. Then raise the temperature to 290°C to decompose iron oleate to obtain magnetic polymer microspheres.

[0056] The particle size and particle size distri...

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Abstract

The invention discloses a preparation method of a magnetic polymer microsphere. The preparation method includes the steps of: adding a polymer seed into an aqueous solution containing a stabilizer andan initiator, and stirring the substances uniformly to form a uniformly dispersed seed suspension; mixing ferric oleate and a monomer uniformly to form a ferric oleate monomer solution; enabling theferric oleate monomer solution to form uniform liquid drops through a nozzle and enter the seed suspension, letting the seed absorb the liquid drops for growth and one-step polymerization so as to obtain ferric oleate polymer microsphere; and raising the temperature to decompose the ferric oleate so as to obtain the magnetic polymer microsphere. The magnetic polymer microsphere prepared by the method provided by the invention not only can control the magnetic performance of the microsphere, but also can further improve the particle size uniformity of the microsphere, moreover, the yield, efficiency and stability of the magnetic polymer microsphere are improved, and the method is suitable for large-scale production.

Description

technical field [0001] The invention relates to the field of polymer materials, in particular to a preparation method of magnetic polymer microspheres. Background technique [0002] In recent years, magnetic polymer microspheres have been widely used in the fields of nucleic acid extraction, cell separation, immobilized enzymes, immunoassays, targeted drugs, separation and purification of proteins and enzymes, etc. However, how to synthesize magnetic polymer microspheres with uniform particle size and controllable magnetic properties is a hot and difficult point in current research in related fields. [0003] The traditional methods for synthesizing magnetic polymer microspheres in the prior art mainly include embedding method, monomer polymerization method and interface deposition method. [0004] At present, this synthesis method not only has uncontrollable particle size of magnetic polymer microspheres, but also has poor uniformity. Moreover, there are many uncontrollab...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F120/18C08F112/08C08F112/14C08F120/32C08F120/06C08F2/44C08K5/098B01J13/14H01F1/42
CPCB01J13/14C08F2/44C08F112/08C08F112/14C08F120/06C08F120/18C08F120/32C08K5/098C08K2201/01H01F1/42
Inventor 阳承利
Owner 无锡迈科为生物科技有限公司
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