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Double-layer controlled-release tablets for improving sleep and beautifying features and preparation method

A technology for improving sleep and controlled-release tablets, applied in the field of food, can solve problems such as too fast release, and achieve the effects of improving sleep, reducing the frequency of taking, and prolonging the action time.

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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Aiming at the problem of too fast release of current products containing GABA and magnesium ions, the present invention provides a double-layer controlled-release tablet for improving sleep and beautification.

Method used

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  • Double-layer controlled-release tablets for improving sleep and beautifying features and preparation method
  • Double-layer controlled-release tablets for improving sleep and beautifying features and preparation method
  • Double-layer controlled-release tablets for improving sleep and beautifying features and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1 Preparation of double-layer controlled-release tablets for improving sleep and beauty (1000 mg per tablet)

[0034] Table 1 The weight of the double-layer controlled-release tablets of each sample S1-3 and reference substance C2-5 (1 piece, 1000mg)

[0035]

[0036]

[0037] Table 2 The content and ratio of each active ingredient in the immediate-release layer and the sustained-release layer

[0038]

[0039] Note: Content refers to the mass percentage in the whole double-layer controlled-release tablet.

[0040] Take each raw material according to table 1 weight, carry out tablet preparation according to the following method:

[0041] (1) Take jujube seed extract, GABA, sodium hyaluronate, magnesium-containing compounds, disintegrants, fillers, and lubricants and pass through an 80-mesh sieve, and set aside;

[0042] (2) Preparation of immediate-release layer: Weigh GABA, sodium hyaluronate, disintegrant, filler, lubricant and mix evenly, add an ap...

Embodiment 2

[0047] Example 2 Determination of Release

[0048] With reference to the second appendix XD first method of the 2015 edition of the Pharmacopoeia, take each 6 double-layer controlled-release tablets obtained in the examples and comparative examples, add 1000ml of 0.1mol / L hydrochloric acid solution, centrifuge, and rotate at 100r / min for 2 hours. , 4 hours, 8 hours, 12 hours, and 18 hours respectively take out 10mL of the solution, filter, and add 10mL of 0.1mol / L hydrochloric acid solution in the operation container in time. Take the filtrate and measure the GABA content according to the method stipulated in the high-performance liquid chromatography determination method of gamma-aminobutyric acid in "Health Food Functional Components Detection Method" (Bai Hong. China Press of Traditional Chinese Medicine, 2011), calculate the cumulative release percentage of GABA, and the result as shown in Table 3.

[0049] Table 3 Cumulative release percentage of different tablets

[00...

Embodiment 3

[0052] Example 3 Product Safety Verification

[0053] 1. Materials and methods

[0054] 1.1 Subjects

[0055] 400 volunteers with frequent insomnia, easy to wake up, insomnia, dry skin (skin moisture ≤ 10), and sallow complexion were selected as test subjects, half male and half male, aged 35-60 years old.

[0056] Subject exclusion criteria:

[0057] (1) Pregnant or breastfeeding women, allergic constitution and those who are allergic to this health food;

[0058] (2) Combined with cardiovascular and cerebrovascular diseases, liver, kidney, hematopoietic system diseases and mental illness history;

[0059] (3) Taking items related to the test function in a short period of time, which will affect the judgment of the results;

[0060] (4) Failure to take the test sample according to the test requirements, unable to determine the efficacy or incomplete data affect the efficacy or safety judgment.

[0061] Table 4 Grouping of subjects (mean ± standard deviation)

[0062] ...

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Abstract

The invention provides health-care products namely double-layer controlled-release tablets having efficacy of improving sleep and beautifying features. The double-layer controlled-release tablets comprise quick-release layers and sustained-release layers, wherein the quick-release layers comprise GABA and sodium hyaluronate, the sustained-release layers comprise GABA, magnesian compounds, a spinadate seed extract and sodium hyaluronate, the weight ratio of GABA in the quick-release layers and to the GABA in the sustained-release layers is (0.3-3) to 1, the weight ratio of the sodium hyaluronate in the quick-release layers to the sodium hyaluronate in the sustained-release layers is (0.6-3) to 1, the molecular weight of the sodium hyaluronate in the quick-release layers is(0.2-0.6)*10<6>Da, and the molecular weight of the sodium hyaluronate in the sustained-release layers is (1.2-2.5)*10<6>Da. According to the double-layer controlled-release tablets disclosed by the invention, the GABA, the magnesian compounds, the spina date seed extract and the sodium hyaluronate are used as effective components, so that good efficacy of controlled release of components and substances for improving sleep can be achieved. The proportion, the content or the kind of the effective components in different layers are adjusted, so that the effect of improving sleep can be quickly achieved, the effect of prolonging action time can be achieved, and the administration number of times can be reduced.

Description

technical field [0001] The invention belongs to the field of food, and relates to a double-layer controlled-release tablet and a preparation method. Background technique [0002] Insomnia, also known as sleep disorder, refers to a sleep disorder syndrome in which sleep initiation and sleep maintenance are disturbed, resulting in sleep quality that cannot meet individual physiological needs and significantly affects patients' daytime activities. The harms caused by lack of sleep include lack of energy, slow response, memory loss, decreased immunity, and even premature aging of the body. The skin is the largest organ of the human body, which is involved in absorption, excretion, protection, and metabolism of various substances. The active metabolism of human epidermal cells is from the early morning to 2:00 the next day. During this time, the collagen and keratin of the skin are constantly renewed. If you are suffering from insomnia In this condition, skin metabolism will be ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/24A61K36/725A61P17/00A61P25/20A61K31/197A61K31/728A61K31/191A61K33/06
CPCA61K9/209A61K31/191A61K31/197A61K31/728A61K33/06A61K36/725A61P17/00A61P25/20A61K2300/00
Inventor 姜秀敏宋永民冯晓毅宫衍革甄文博刘栋郭学平
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