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Aesculin nano-suspension gel and preparation method and application thereof

A technology of nano-suspension, quincetin, which is used in pharmaceutical formulations, aerosol delivery, medical preparations of non-active ingredients, etc., to achieve the effects of improving solubility, improving ability, and improving biofilm permeability

Active Publication Date: 2019-12-06
科贝园(北京)医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, there are still many possibilities for the study of echinocortin

Method used

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  • Aesculin nano-suspension gel and preparation method and application thereof
  • Aesculin nano-suspension gel and preparation method and application thereof
  • Aesculin nano-suspension gel and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The preparation method of fencutelin nano-suspension is as follows:

[0042] 1) Weighing the crude drug of echinocetin, dissolving it with methanol to obtain an organic phase;

[0043] 2) dissolving the stabilizer in purified water to obtain an aqueous phase;

[0044] 3) Under stirring at room temperature, slowly add the organic phase to the water phase, and magnetically stir to disperse alopecia evenly in the water phase, and remove methanol by rotary evaporation to obtain a coarse suspension;

[0045] 4) The coarse suspension is subjected to high-speed shearing treatment and micro-jet high-pressure homogenization treatment successively to obtain agaricin nanosuspension;

[0046] (1) The influence of stabilizing agent on the preparation of afrucetin nanosuspension

[0047] 1) Completely dissolve 50 mg of afraetin in 3 mL of methanol to obtain an organic phase.

[0048] 2) Take the stabilizer as shown in Table 1 and dissolve it in 50 mL of purified water to obtain th...

Embodiment 2

[0098] Aurocetin nano-suspension gel

[0099] (1) The specific preparation method is as follows: figure 1 shown, including the following steps:

[0100] 1) Completely dissolve 50 mg of afraetin in 3 mL of methanol to obtain an organic phase.

[0101] 2) 30 mg of poloxamer 188 and 35 mg of soybean lecithin were dissolved in 50 mL of purified water to obtain an aqueous phase.

[0102] 3) Under the condition of 25°C, slowly drop the organic phase into the water phase, stir magnetically for 20 min, so that the auretin is evenly dispersed in the water phase, and then remove the methanol by rotary evaporation to obtain a coarse suspension.

[0103] 4) The coarse suspension is firstly sheared by a high-speed shearing machine at 20,000 rpm for 1 min for high-speed shearing treatment. Then the resulting mixed solution was passed through the micro jet at 13.6×10 7 Homogenization under pressure was carried out three times for micro-jet high-pressure homogenization treatment to obtain...

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Abstract

The invention discloses aesculin nano-suspension gel and a preparation method and application thereof. Aesculin and a stabilizer are made into an aesculin nano-suspension agent, a gel matrix, a moisturizer and a pH regulator are further added, and the aesculin nano-suspension gel is prepared. According to the aesculin nano-suspension gel prepared by combining a precipitation method with a microjethigh-pressure homogenization method, the drug solubility and skin permeability can be increased, transmembrane transport of the aesculin nano-suspension gel can be promoted, the administration dosageis decreased, the toxic and side effects are reduced, the better therapeutic effect can be exerted in the body advantageously, and the ability to pass through a lipid bilayer is improved.

Description

technical field [0001] The present invention relates to the field of pharmaceutical preparations, in particular to a patricarin nano-suspension gel and its preparation method and application. Background technique [0002] Qinpi is the dry bark or bark of Fraxinus rhynchophylla Hance, Fraxinus szaboana Lingelsh. or Fraxinus stylosa Lingelsh. [0003] Aesculin (aesculin) is a coumarin derivative with a relatively high content in aesculin, which has anti-inflammatory, anti-tumor, and lowering blood uric acid effects. It has been proved that auricine has poor fat solubility and may have malabsorption when passing through the phospholipid bilayer in the gastrointestinal tract. It has also been reported that oral adrenalin is ineffective in reducing blood uric acid. The dosage is large and the residence time in the body is short. . According to the test method of the fourth part of the "Chinese Pharmacopoeia" 2015 edition, the solubility of echinocortidine is tested, and it show...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/10A61K47/32A61K47/24A61K31/7048A61P35/00
CPCA61K9/06A61K9/0014A61K47/10A61K47/32A61K47/24A61K31/7048A61P35/00
Inventor 陈立江石金燕宋柯褚宇琦王惊雷
Owner 科贝园(北京)医药科技有限公司
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