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Compound spraying and film agent for dairy cows, and preparation method thereof

A film-spraying agent and compound technology, applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve the problems of poor curative effect, inability to treat, slow curative effect, etc., and achieve film-forming speed Fast, good absorption, high healing rate

Active Publication Date: 2019-12-06
ZHENGZHOU BARY ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to solve the problem of poor curative effect and slow curative effect of the traditional Chinese medicine spray film agent and the problem that the single-component povidone can only prevent cow mastitis and cannot treat it, and propose a compound spray film agent for dairy cows and its preparation method

Method used

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  • Compound spraying and film agent for dairy cows, and preparation method thereof
  • Compound spraying and film agent for dairy cows, and preparation method thereof
  • Compound spraying and film agent for dairy cows, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment one kind of compound spray film agent for cows, this film spray agent is made of the following components by weight: 5 parts of povidone iodine, 2 parts of clove oil, 5 parts of dimethyl sulfone, PVB (polyvinyl alcohol Butyral) 7 parts, HPMC E5 (hydroxypropyl methylcellulose) 2 parts, 2 parts of propylene glycol, 1 part of menthol, 1 part of azone, 75 parts of the mixture of purified water and 95% ethanol (the ratio of the two is 1:8).

[0024] The preparation method of the above-mentioned compound spray film agent for cows comprises the following steps: taking each raw material according to the above parts by weight, dissolving PVB into 95% ethanol of 50% prescription amount to obtain solution A; mixing clove oil, menthol, azone Add propylene glycol and 95% ethanol to 50% prescription amount and stir to obtain a clear solution, then add HPMC E5 to obtain a suspension solution B; dissolve dimethyl sulfone in purified water, add povidone-iodine and stir to dispe...

Embodiment 2

[0025] Embodiment two a kind of compound spray film agent for cows, this film spray agent is made of the following components by weight: 5 parts of povidone iodine, 2 parts of clove oil, 5 parts of dimethyl sulfone, PVB (polyvinyl alcohol 4 parts of butyral), 1 part of HPMC E5 (hydroxypropyl methylcellulose), 2 parts of propylene glycol, 1 part of borneol, 1 part of azone, 79 parts of a mixture of purified water and 95% ethanol (the ratio of the two is 1 :8).

[0026] The preparation method of the above-mentioned compound spray film agent for cows comprises the following steps: taking each raw material according to the above parts by weight, dissolving PVB into 95% ethanol of 50% prescription amount to obtain solution A; mixing clove oil, borneol, azone and Add propylene glycol to 95% ethanol with 50% prescription quantity and stir to obtain a clear solution, then add HPMC E5 to obtain a suspension solution B; dissolve dimethyl sulfone in purified water, add povidone-iodine an...

Embodiment 3

[0027] Embodiment three a kind of compound spray film agent for cows, this film spray agent is made of the following components by weight: 5 parts of povidone iodine, 2 parts of clove oil, 5 parts of dimethyl sulfone, PVB (polyvinyl alcohol Butyral) 6 parts, HPMC E5 (hydroxypropyl methylcellulose) 1.5 parts, propylene glycol 2 parts, borneol 1 part, menthol 0.5 part, azone 1 part, 79 parts of the mixture of purified water and 95% ethanol ( The ratio of the two is 1:8).

[0028] The preparation method of the above-mentioned compound spray film agent for cows comprises the following steps: taking each raw material according to the above parts by weight, dissolving PVB into 95% ethanol of 50% prescription amount to obtain solution A; mixing clove oil, borneol, menthol, Add azone and propylene glycol to 95% ethanol of 50% recipe quantity and stir to obtain a clear solution, then add HPMC E5 to obtain a suspension solution B; dissolve dimethyl sulfone in purified water, add povidon...

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Abstract

The invention belongs to the technical field of veterinary medicine preparations, and discloses a compound spraying and film agent for dairy cows. The spraying and film agent is prepared from the following components in parts by weight: 1-5 parts of povidone iodine, 0.1-2 parts of clove oil, 2-8 parts of dimethyl sulfone, 3-10 parts of a film-forming agent, 0.5-2 parts of a thickening agent, 0.5-2parts of a wetting agent, 0.5-2.5 parts of a transdermal absorption enhancer and 70-90 parts of a solvent, wherein the solvent is a mixture of an alcoholic solvent and an aqueous solvent. According to the compound spraying and film agent, the povidone iodine, the clove oil, borneol / menthol and the dimethyl sulfone are taken as the main compound components; the dimethyl sulfone is applied to the spraying and film agent for the mastitis of the dairy cows for the first time, so that the antibacterial and disinfection capability of the povidone iodine and the clove essential oil is improved, thehealing of the breast wounds of the dairy cows is promoted, and the problem that a traditional spraying and film agent only adopts a povidone iodine single-component preparation and can only prevent and cannot treat the mastitis of the dairy cows is solved; and compared with other external preparations for the mastitis of the dairy cows, the compound spraying and film agent is uniform in coating,high in film-forming speed, free of sagging and dropping phenomena, obvious in wound healing promotion effect and high in cure rate.

Description

technical field [0001] The invention belongs to the technical field of veterinary drug preparations, and in particular relates to a compound spray film agent for cows and a preparation method thereof. Background technique [0002] Cow mastitis is mainly caused by various pathogenic microorganisms such as Staphylococcus aureus, Streptococcus, Escherichia coli, etc. It will affect the quality of dairy products and endanger food hygiene and safety. The dosage forms for preventing and treating dairy cow mastitis mainly include injections, infusions, powders, and transdermal preparations. Transdermal preparations can be divided into cataplasms, coatings, sprays, sprays, etc. according to different drug carriers. (1) Catapults: Catalysts refer to external dosage forms in which drugs are dissolved or mixed in a water-soluble polymer matrix and spread on the backing material for skin sticking. The cataplasm has good adhesion to the skin, and it is clean and has no residue when it...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/61A61K9/70A61K47/38A61K47/32A61P15/14A61P31/04A61K31/045A61K31/10A61K31/79
CPCA61K9/7015A61K31/045A61K31/10A61K31/79A61K36/61A61K47/32A61K47/38A61P15/14A61P31/04A61K2300/00
Inventor 陈长青刘示范丁佳丽周衡崔小七陈盟梁桂霞
Owner ZHENGZHOU BARY ANIMAL PHARMA
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