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Noble metal nanoparticulates/g-C3N4 composite material and preparation method and application thereof

A nanoparticle and composite material technology, applied in wave energy or particle radiation treatment materials, drug combinations, pharmaceutical formulations, etc., can solve problems such as difficulty in applying large-scale disease treatment, inability to decompose protein fiber aggregates, etc., and achieve improvement. Photocatalytic ability, the effect of prolonging life

Inactive Publication Date: 2019-12-06
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These inhibitors are believed to inhibit the aggregation process of amyloid (polypeptide) monomers, but most of them cannot break down the aggregated protein fibrils
In addition, although a variety of enzymes including neprilysin, insulin-degrading enzyme and endothelin-converting enzyme have the ability to degrade amyloid Aβ (33-42) monomers, the above-mentioned several enzymes are more cytotoxic to amyloid Oligomers of protein-like proteins (polypeptides) are insensitive, and these enzymes are difficult to apply to large-scale disease treatment due to the influence of various factors

Method used

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  • Noble metal nanoparticulates/g-C3N4 composite material and preparation method and application thereof
  • Noble metal nanoparticulates/g-C3N4 composite material and preparation method and application thereof
  • Noble metal nanoparticulates/g-C3N4 composite material and preparation method and application thereof

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preparation example Construction

[0030] Noble metal nanoparticles / g-C according to the present invention 3 N 4 The preparation method of composite material, comprises the following steps:

[0031] (1) Ultra-thin g-C 3 N 4 Preparation of nanosheets: preparation of bulk g-C by high-temperature treatment of melamine 3 N 4 , exfoliated g-C in liquid 3 N 4 Get g-C 3 N 4 Nanosheets;

[0032] (2) Noble metal nanoparticles / g-C 3 N 4 Composite material preparation:

[0033] First, prepare the noble metal reduction reaction solution, and add the g-C prepared above to the solution 3 N 4 nanosheets, and stirred, to immobilize the reduced Au on the g-C 3 N 4 On nanosheets, noble metal nanoparticles / g-C 3 N 4 The composite was then filtered, washed and dried overnight at 393K.

[0034] With gold nanoparticles / g-C 3 N 4 Taking the composite material as an example, its preparation method is as follows:

[0035] Melamine was heated to 600°C for 2 hours at a rate of 3°C / min; the yellow product obtained was g...

Embodiment 1

[0040] Embodiment 1: Degradation of organic molecule rhodamine

[0041] We measured 1mg / mL Au / g-C 3 N 4 The degradation ability of 0.1g / L rhodamine B (RhB) under UV irradiation, and C 3 N 4 For the control example. Degradation effect such as Figure 4 As shown, with the increase of illumination time, the absorption peak of rhodamine is gradually disappearing. The g-C loaded with Au nanoparticles 3 N 4 The material completely degrades Rhodamine B (RhB) within 1 hour.

[0042] Figure 4 for C 3 N 4 and Au / g-C 3 N 4 Comparison of material degradation rhodamine experiments, (a) use ultraviolet absorption spectrum to analyze the degradation process; (b) the absorption spectrum is at 555nm. Characterization of Au / g-C by UV Absorption Spectroscopy 3 N 4 and g-C 3 N 4 Differences in the effect of degrading rhodamine. After 60 minutes of degradation, the former Au / g-C 3 N 4 Than g-C 3 N 4 Degradation rate increased by 10%.

Embodiment 2

[0043] Embodiment 2: Degradation of amyloid (polypeptide) and aggregates thereof

[0044] Using Au / g-C 3 N 4 Degradation of amyloid protein Amylin (20-29) self-assembled products as an example. Amylin (20-29) monomer solution purchased from Shanghai Cotide Biotechnology Co., Ltd. was incubated at 37°C for 10 hours to prepare amyloid aggregation products. Then the incubation product and Au / g-C 3 N 4 The mixture was irradiated under ultraviolet light to degrade the amyloid aggregation products prepared above. The aggregates of Amylin (20-29) were used as a positive control, and the morphology of the degradation products was characterized by atomic force microscopy (AFM) after the amyloid aggregates were degraded under UV irradiation.

[0045] according to Figure 5 The results of AFM showed that the undegraded aggregates present a large number of fibers, and the height of the fibers is mostly distributed between 1-3nm, such as Figure 5 (a) shown. After Au / g-C 3 N 4 Af...

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Abstract

The invention provides a noble metal nanoparticles / g-C3N4 composite material and a preparation method and application thereof. According to the invention, noble metal is loaded to the surface of g-C3N4, noble metal nanoparticles have relatively strong plasma resonance characteristics and can capture and store generated free electrons, so that the service life of locally-generated plasmas is prolonged, and the photocatalytic capability of graphite carbonitride (g-C3N4) is improved. The composite material can be used for degrading amyloid protein aggregates and further treating diseases caused by the amyloid protein aggregates, and can be used for preparing medicines for treating diseases caused by the amyloid protein aggregates, and can also be used for degrading rhodamine.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, especially noble metal nanoparticles / g-C 3 N 4 Composite materials, preparation methods and uses. Background technique [0002] The high incidence of amyloidosis-related diseases represented by Alzheimer's disease and the inability to completely cure them have aroused widespread concern. Based on existing research, many amyloidosis diseases such as type 2 diabetes, Alzheimer's disease (AD), Parkinson's disease (Parkinson's Disease), etc. are caused by amyloid (polypeptide) misfolding and abnormal caused by self-assembly. Amyloid (polypeptide) aggregation and fibrous tangles in patients are one of the characteristics of the disease. The process of amyloid self-assembly and aggregation to form protein fibers is that amyloid (polypeptide) is derived from its soluble, unstructured protein monomers. In the process of abnormal aggregation into insoluble amyloid fibers rich in β-fold st...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61P25/28A61P25/16
CPCA61K41/0057A61P25/16A61P25/28
Inventor 汪杰刘磊冯永海
Owner JIANGSU UNIV
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