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Poly-L-lactic acid (PLLA)/ZIF-8 composite bone scaffold and preparation method thereof

A technology of ZIF-8 and ZIF-80.5, applied in medical science, tissue regeneration, prosthesis, etc., can solve the problems of low cell activity, slow degradation rate, insufficient mechanical strength, etc., to enhance mechanical properties, promote dispersion, improve The effect of interface binding ability

Active Publication Date: 2019-12-06
JIANGXI UNIV OF SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the problems of insufficient mechanical strength, slow degradation rate and low cell activity in PLLA used as a bone implant material in the prior art, the purpose of the present invention is to provide a PLLA / ZIF with excellent mechanical properties, suitable degradation rate and high cell activity. -8 Composite bone scaffold and preparation method thereof

Method used

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  • Poly-L-lactic acid (PLLA)/ZIF-8 composite bone scaffold and preparation method thereof
  • Poly-L-lactic acid (PLLA)/ZIF-8 composite bone scaffold and preparation method thereof
  • Poly-L-lactic acid (PLLA)/ZIF-8 composite bone scaffold and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] (1) Use an electronic balance to weigh 0.4g of ZIF-8 powder with a particle size of 0.5-4μm, add it to a beaker filled with 30mL of absolute ethanol solution, and obtain a uniform and stable ZIF-8 suspension after ultrasonic stirring liquid.

[0046] (2) Weigh 19.6 g of PLLA powder with an electronic balance, the particle size is 100-150 μm, add it into a beaker containing 50 mL of absolute ethanol solution, and stir it ultrasonically to obtain a uniform and stable PLLA suspension.

[0047] (3) Add the PLLA suspension dropwise to the mixed suspension of ZIF-8, then mix the mixed solution evenly by magnetic stirring and ultrasonic dispersion, the time of mechanical stirring is 60min, the speed is 900r / min, and the temperature is 50°C , and then filter the uniformly mixed suspension and dry it under vacuum at 50° C. for 12 hours, and finally grind to obtain a uniform PLLA / ZIF-8 composite powder.

[0048] (4) Spread the composite powder obtained above in the selective las...

Embodiment 2

[0052] (1) Use an electronic balance to weigh 0.2g of ZIF-8 powder with a particle size of 0.5-4μm, add it to a beaker filled with 30mL of absolute ethanol solution, and obtain a uniform and stable ZIF-8 suspension after ultrasonic stirring liquid.

[0053] (2) Weigh 19.8 g of PLLA powder with an electronic balance, the particle size is 100-150 μm, add it into a beaker containing 50 mL of absolute ethanol solution, and obtain a uniform and stable PLLA suspension after ultrasonic stirring.

[0054] (3) Add the PLLA suspension dropwise to the mixed suspension of ZIF-8, and then mix the mixed solution evenly through magnetic stirring and ultrasonic dispersion. The time of magnetic stirring is 60min, the speed is 900r / min, and the temperature is 50°C , and then filter the uniformly mixed suspension and dry it under vacuum at 50° C. for 12 hours, and finally grind to obtain a uniform PLLA / ZIF-8 composite powder.

[0055] (4) Spread the composite material powder obtained above in t...

Embodiment 3

[0059] (1) Use an electronic balance to weigh 0.6g of ZIF-8 powder with a particle size of 0.5-4μm, add it to a beaker filled with 30mL of absolute ethanol solution, and obtain a uniform and stable ZIF-8 suspension after ultrasonic stirring liquid.

[0060] (2) Weigh 19.4 g of PLLA powder with an electronic balance, the particle size is 100-150 μm, add it into a beaker containing 50 mL of absolute ethanol solution, and obtain a uniform and stable PLLA suspension after ultrasonic stirring.

[0061] (3) Add the PLLA suspension dropwise to the mixed suspension of ZIF-8, and then mix the mixed solution evenly through magnetic stirring and ultrasonic dispersion. The time of magnetic stirring is 60min, the speed is 900r / min, and the temperature is 50°C , and then filter the uniformly mixed suspension and dry it under vacuum at 50° C. for 12 hours, and finally grind to obtain a uniform PLLA / ZIF-8 composite powder.

[0062] (4) Spread the composite powder obtained above in the select...

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Abstract

The invention provides a poly-L-lactic acid (PLLA) / ZIF-8 composite bone scaffold and a preparation method thereof. The composite bone scaffold is prepared from the following components in percentage by weight: 97-99.5% of PLLA, and 0.5-3% of ZIF-8. The preparation method of the composite bone scaffold includes the steps that the PLLA and ZIF-8 powder are subjected to liquid-phase mixing, and through stirring, ultrasound, separation and drying, composite powder is obtained; and then by utilizing a selective laser sintering process, after the composite powder is sintered layer by layer, the PLLA / ZIF-8 composite bone scaffold is finally obtained. By utilizing good combination between the ZIF-8 and a PLLA substrate, interface combination between the PLLA and the ZIF-8 is improved, and thus themechanical strength of the composite bone scaffold is improved; and in addition, by utilizing the characteristic of degradation of the ZIF-8 in the acidic environment, the degradation rate of the PLLA is increased, and cell proliferation is improved.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and in particular relates to a PLLA / ZIF-8 bone scaffold and a preparation method thereof. Background technique [0002] As a typical biodegradable polymer material, poly-L-lactic acid (PLLA) has the advantages of wide sources, non-toxic degradation products and good biocompatibility. In addition, PLLA is also one of the few biodegradable implant materials approved by the US Food and Drug Administration (FDA). However, PLLA's relatively insufficient mechanical strength, relatively slow degradation rate, and low biological activity limit its application in the field of bone repair. [0003] In view of the insufficient mechanical strength of PLLA, some scholars proposed to add inorganic nano-nucleating agents to enhance its mechanical strength. The method uses the heterogeneous nucleation effect of nano-nucleating agents to induce the nucleation of polymers on it and accelerate the crystalliza...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44A61L27/50A61L27/58
CPCA61L27/44A61L27/446A61L27/50A61L27/58A61L2430/02C08L67/04
Inventor 杨友文帅词俊彭淑平昝君
Owner JIANGXI UNIV OF SCI & TECH
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