Massage cream containing cannabidiol nanoliposomes and preparation method thereof

A cannabidiol nano-liposome technology, which is applied in skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., can solve the problem of cannabidiol being insoluble in water, etc., and increase transdermal absorption efficiency and bioavailability , scavenging free radicals, long-lasting effect

Inactive Publication Date: 2019-12-13
YUNNAN LVXIN BIOLOGICAL PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] An object of the present invention is to use liposome technology to prepare nano-sized cannabidiol, solve the problem of cannabidiol being insoluble in water, and increase the transdermal absorption effect of cannabidiol while improving its water solubility and stability. It allows CBD to quickly and effectively penetrate the surface of the skin, reach the deep layer of the skin and release CBD slowly, making its effect longer lasting

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) The preparation of cannabidiol nanoliposomes comprises the following steps:

[0028] ①Preparation of the organic phase: Accurately weigh 10 mg of cannabidiol, 100 mg of phospholipid and 20 mg of cholesterol and add them to ethanol, heat and stir to fully dissolve to obtain the organic phase.

[0029] ② Film production: Evaporate the organic phase obtained in step ① on a rotary evaporator to remove the solvent, so that the residue forms a phospholipid film on the inner wall of the container. The rotary evaporation temperature is 40 ° C and the vacuum degree is 0.1 MPa.

[0030] ③Hydration: Slowly add 10ml of 0.01mol / L phosphate buffer (pH6.5) into the phospholipid film container, and continue rotary steaming for 1 hour to make the phospholipid film fall off to obtain cannabidiol liposome suspension.

[0031] ④ Homogenization: inject the above suspension into a high-pressure homogenizer for 3 times for homogenization, the homogenization pressure is 30MPa, after homoge...

Embodiment 2

[0039] (1) The preparation of cannabidiol nanoliposomes comprises the following steps:

[0040] ①Preparation of the organic phase: Accurately weigh 10 mg of cannabidiol, 200 mg of phospholipids and 50 mg of cholesterol and add them to ethanol, heat and stir to fully dissolve to obtain an organic phase.

[0041] ② Film production: Evaporate the organic phase obtained in step ① to remove the solvent on a rotary evaporator, so that the residue forms a phospholipid film on the inner wall of the container. The rotary evaporation temperature is 40 ° C and the vacuum degree is 0.2 MPa.

[0042] ③Hydration: Slowly add 15ml of 0.01mol / L phosphate buffer (pH7.0) into the phospholipid film container, and continue rotary steaming for 2 hours to make the phospholipid film fall off to obtain cannabidiol liposome suspension.

[0043] ④ Homogenization: Inject the above suspension into a high-pressure homogenizer for 2 times for homogenization, the homogenization pressure is 20MPa, after homog...

Embodiment 3

[0051] (1) The preparation of cannabidiol nanoliposomes comprises the following steps:

[0052] ①Preparation of the organic phase: Accurately weigh 10 mg of cannabidiol, 300 mg of phospholipids and 100 mg of cholesterol and add them to ethanol, heat and stir to fully dissolve to obtain an organic phase.

[0053] ② Film production: Evaporate the organic phase obtained in step ① on a rotary evaporator to remove the solvent, so that the residue forms a phospholipid film on the inner wall of the container. The rotary evaporation temperature is 50 ° C and the vacuum degree is 0.1 MPa.

[0054] ③Hydration: Slowly add 20ml of 0.02mol / L phosphate buffer (pH8.0) to the phospholipid film container, and continue rotary steaming for 3 hours to make the phospholipid film fall off and obtain cannabidiol liposome suspension.

[0055] ④ Homogenization: inject the suspension into a high-pressure homogenizer for 3 times for homogenization, the homogenization pressure is 40MPa, after homogenizat...

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Abstract

The invention discloses a massage cream containing cannabidiol nanoliposomes and a preparation method thereof. The massage cream comprises the following raw materials in percentage by mass: 0.1-1% ofcannabidiol nanoliposome, 5-10% of beeswax, 5-10% of glycerol, 2-5% of glyceryl monostearate, 1-5% of cetyl alcohol, 1-5% of isopropyl myristate, 1-5% of ethylhexyl palmitate, 0.5-2% of ceteareth-20,0.5-1% of essential oil, 0.1-1% of carbomer, 0.05-0.1% of triethanolamine, 0.01-0.1% of phenoxyethanol, and the balance deionized water. According to the invention, nano-scale cannabidiol (CBD) is prepared by adopting a liposome technology, so that the water solubility and stability of the CBD are improved, and meanwhile, the transdermal absorption effect of the CBD is promoted, so that the CBD can quickly and effectively penetrate through the surface layer of the skin and directly reach the deep layer of the skin, the CBD is slowly released, and the effect is more durable. The massage cream containing the cannabidiol nanoliposomes can effectively remove free radicals, and has good effects of resisting inflammation, resisting oxidation and delaying senescence.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and in particular relates to a massage cream containing cannabidiol nano-liposome and a preparation method thereof. Background technique [0002] Massage cream is used in conjunction with skin massage. It has the function of lubricating and increasing the massage effect. Different massage creams have different effects with different massage techniques, such as whitening, moisturizing, anti-wrinkle, detoxification, etc. With the development of nanotechnology, nanomaterials are being used more and more in the cosmetics industry. Functional active ingredients are wrapped in nanometer-sized capsules, and nanocapsules are used as carriers to automatically and uniformly slow release on skin tissue. , so that the active ingredients can be maintained in the effective concentration for a long time, which can stabilize the active ingredients and reduce the stimulation of special additives to the skin. D...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/92A61K8/34A61K8/14A61Q19/08
CPCA61K8/14A61K8/347A61K8/922A61K8/927A61Q19/08
Inventor 王钲霖刘胜贵薛红芬付彬彬李智高孔令羽
Owner YUNNAN LVXIN BIOLOGICAL PHARMA CO LTD
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