The invention discloses a massage cream containing cannabidiol nanoliposomes and a preparation method thereof. The massage cream comprises the following raw materials in percentage by mass: 0.1-1% ofcannabidiol nanoliposome, 5-10% of beeswax, 5-10% of glycerol, 2-5% of glyceryl monostearate, 1-5% of cetyl alcohol, 1-5% of isopropyl myristate, 1-5% of ethylhexyl palmitate, 0.5-2% of ceteareth-20,0.5-1% of essential oil, 0.1-1% of carbomer, 0.05-0.1% of triethanolamine, 0.01-0.1% of phenoxyethanol, and the balance deionized water. According to the invention, nano-scale cannabidiol (CBD) is prepared by adopting a liposome technology, so that the water solubility and stability of the CBD are improved, and meanwhile, the transdermal absorption effect of the CBD is promoted, so that the CBD can quickly and effectively penetrate through the surface layer of the skin and directly reach the deep layer of the skin, the CBD is slowly released, and the effect is more durable. The massage cream containing the cannabidiol nanoliposomes can effectively remove free radicals, and has good effects of resisting inflammation, resisting oxidation and delaying senescence.