Alpha-tricalcium phosphate and preparation method thereof

A technology of tricalcium phosphate and calcium hydrogen phosphate, applied in the field of α-tricalcium phosphate and its preparation, can solve the problems of easy agglomeration in the sintering process of α-tricalcium phosphate, and achieve the effects of simple preparation method and simple preparation process

Active Publication Date: 2019-12-13
GUANGZHOU RAINHOME PHARM&TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the deficiencies of the prior art and provide a kind of α-tricalcium phosphate and its preparation method, to solve the problem of easy agglomeration in the sintering process of the current α-tricalcium phosphate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] As an embodiment of the preparation method of α-tricalcium phosphate described in the present invention, the preparation method of α-tricalcium phosphate described in this embodiment comprises the following steps:

[0036] 1) Calcium carbonate (CaCO 3 ) and calcium hydrogen phosphate (CaHPO 4 • 2H2O) mixed evenly at a molar ratio of 2:1, adding absolute ethanol at a volume ratio of powder to alcohol of 1:2, ball milling in a ball mill at a speed of 200 rpm for 40 min, and placed in a muffle at 900°C Calcined in the furnace for 1 h, cooled with the furnace, and the cooled powder passed through a 10 μm sieve to obtain powder A.

[0037] 2) Add zirconium dioxide with an average particle diameter of 200 μm to powder A, the mass ratio of powder to zirconium dioxide is: 1:0.5, mix with the above powder evenly, and heat up in a muffle furnace at a rate of 5°C / min After rising to 1350°C, keep it warm for 5 hours, take it out, cool it in the air to room temperature, pass it th...

Embodiment 2

[0039] As an embodiment of the preparation method of α-tricalcium phosphate described in the present invention, the preparation method of α-tricalcium phosphate described in this embodiment comprises the following steps:

[0040] 1) Calcium carbonate (CaCO 3 ) and calcium hydrogen phosphate (CaHPO 4 • 2H 2 O) Mix evenly at a molar ratio of 2:1, add absolute ethanol at a ratio of 1:2 by volume of powder and alcohol, mill in a ball mill for 30 min at a speed of 200 rpm, and place in a muffle furnace at 900°C Internally calcined for 1 h, cooled with the furnace, and the cooled powder passed through a 150 μm sieve to obtain powder A.

[0041] 2) Add zirconium dioxide with an average particle diameter of 500 μm to powder A, the mass ratio of powder to zirconium dioxide is: 1:1, mix with the above powder evenly, and heat up in a muffle furnace at a rate of 5°C / min After rising to 1350°C, keep it warm for 4 hours, take it out, cool it in the air to room temperature, pass it throug...

Embodiment 3

[0043] As an embodiment of the preparation method of α-tricalcium phosphate described in the present invention, the preparation method of α-tricalcium phosphate described in this embodiment comprises the following steps:

[0044] 1) Calcium carbonate (CaCO 3 ) and calcium hydrogen phosphate (CaHPO 4 • 2H 2 O) Mix evenly at a molar ratio of 2:1, add absolute ethanol at a volume ratio of powder to alcohol of 1:2, mill in a ball mill for 20 min at a speed of 200 rpm, and place in a muffle furnace at 900°C Internally calcined for 1 h, cooled with the furnace, and the cooled powder passed through a 200 μm sieve to obtain powder A.

[0045] 2) Add zirconium dioxide with an average particle diameter of 1000 μm to powder A, the mass ratio of powder to zirconium dioxide is: 1:2, mix with the above powder evenly, and heat up in the muffle furnace at a rate of 5°C / min After rising to 1350°C, keep it warm for 2 hours, take it out, cool it in the air to room temperature, pass it through...

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Abstract

The invention relates to the technical field of bone repair materials, and discloses a preparation method of alpha-tricalcium phosphate. The problem in alpha-tricalcium phosphate sintering process that agglomeration is easily caused is solved. The preparation method comprises the following steps: (1) mixing calcium hydrophosphate and calcium carbonate by adopting a solid-phase reaction method, grinding for 20-40 minutes, heating to 850-920 DEG C for calcining, cooling, and sieving using a 10-200 micron sieve so as to obtain a powder A; (2) adding the powder A obtained in step (1) into zirconium dioxide powder, increasing the temperature to 1125-1500 DEG C after uniform mixing, carrying out heat preservation for 2-5 h, and then taking an obtained product out, and cooling, wherein the particle size of the zirconium dioxide powder is larger than that of the powder A; 3) sieving to obtain alpha-tricalcium phosphate powder. The above preparation method is capable of reducing agglomeration of alpha-tricalcium phosphate, and maintaining the original size structure of the powder; the grinding step of alpha-tricalcium phosphate after sintering is avoided; the preparation process is simple,and zirconium dioxide can be repeatedly used.

Description

technical field [0001] The invention relates to the technical field of bone repair materials, in particular to α-tricalcium phosphate and a preparation method thereof. Background technique [0002] Calcium phosphate ceramics mainly include hydroxyapatite (HA for short), α-tricalcium phosphate (α-TCP for short), β-tricalcium phosphate (β-TCP for short), etc. Calcium phosphate bioceramic material with three crystal phases. [0003] Tricalcium phosphate has α phase and β phase, β phase is low temperature phase, α phase is high temperature phase, α-TCP is monoclinic system, β-TCP is hexagonal system, β phase transforms into α phase at 1125℃, α-TCP has good comprehensive properties, its biological activity is better than HA, its biocompatibility is better than β-TCP, and its biodegradation rate is faster than β-TCP, so it has attracted more and more attention and has become the current calcium phosphate biological One of the research hotspots of ceramic materials. [0004] P...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32
CPCC01B25/321C01B25/327C01P2004/61
Inventor 车七石单玲星刘少辉张俊辉赵澎
Owner GUANGZHOU RAINHOME PHARM&TECH CO LTD
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