A reactive oxygen species-responsive self-disintegrating hydrogel and its preparation method and application
A technology of hydrogel and active oxygen, which is applied in the direction of medical formula, bandages, drug delivery, etc., can solve the problems affecting the biocompatibility of guar gum, long gelation time, toxic and side effects, etc., so as to promote wound healing, Strong water absorption function, high safety effect
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Embodiment 1
[0031] Example 1 Preparation of GG-CL-IM-BA-1 gel material
[0032] 1. Configuration of IM-BA solution
[0033] 0.1 g of diphenylamine, 0.3 g of 4-formylbenzene boric acid is added to the round bottom flask, and the sealing is added; 700 g of magnetic stirring reaction for 12h, producing yellow precipitate; after the reaction, 12000 g, 4 ° C. Centrifuge 5 min Remove the supernatant, washed 3 times with a pre-cooled methanol at 4 ° C; 12000 g, 4 ° C. Centrifuge again for 5 min, discard the supernatant, and place the precipitate into the vacuum dryer at room temperature for 6 h, ie gave a sample of the sample; Configure 1% solution, 1 M NaOH solution is adjusted to pH 8-9;
[0034] 2. Configuration of Guar Tomber Solution
[0035] Weighing 0.1 g of the pept powder, dissolved in deionized water dissolved in 10 ml of 60 ° C, 60 ° C, 500 g of magnetic force, until Guarum is completely dissolved to give a transparent melon soybean solution.
[0036] 3. Preparation of gel material
[003...
Embodiment 2
[0045] Example 2 Preparation of GG-CL-IM-BA-3 gel Materials
[0046] 1. Configuration of IM-BA solution
[0047] As described in Example 1.
[0048] 2. Configuration of Guar Tomber Solution
[0049] The 0.3 g of a peptamer powder was weighed, dissolved in deionized water of 10 ml of 60 ° C, 60 ° C, 500 g of magnetic force, to give a transparent melon soybean solution.
[0050] 3. Preparation of gel material
[0051] After cooling, after cooling, 300 μl was taken, 100 μl of IM-BA solution, magnetic stirring, and a new self-disonnifying hydrogel material Gg-Cl-Im-BA-3 was obtained based on ROS response.
[0052] 4. Gel properties
[0053] The gel speed is fast, and the gel GG-CL-IM-BA-3 obtained is pale yellow transparent jelly.
[0054] The swelling ratio of hydrogel has risen rapidly in the first 60 min, which basically reaches the swelling balance, the maximum swollen ratio is higher than 1000%, and the flimfalling rate of the hydrogel continues to rise over time, the swelling ra...
Embodiment 3
[0060] Example 3 Preparation of GG-CL-IM-BA-5 GG-CL-IM-BA-5
[0061] 1. Configuration of IM-BA solution
[0062] As described in Example 1.
[0063] 2. Configuration of Guar Tomber Solution
[0064] 0.5 g of a peptamer powder, dissolved in deionized water dissolved in 10 mL of 60 ° C, 60 ° C, 500 g of magnetic force, to give a clear melon soybean solution.
[0065] 3. Preparation of gel material
[0066] After cooling, after cooling of the melon gum, 300 μl was taken, and 200 μl of IM-BA solution was added, and the magnetic stirring was added, i.e., a new self-disonnifying hydrogel material Gg-Cl-Im-BA-5 of ROS response.
[0067] 4. Gel properties
[0068] The gel speed is fast, and the resulting gel GG-CL-IM-BA-5 is pale yellow transparent across or yellow.
[0069] The swelling ratio of hydrogel has risen rapidly in the first 60 min, which basically reaches a swelling balance, the maximum swelling ratio is higher than 1000%, and the flimflation rate of hydrogel continues to rise...
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