Starch-based hemostatic material with time series hemostatic effect and preparation method thereof

Abstract

The invention discloses a starch-based hemostatic material with a time series hemostatic effect and a preparation method thereof. The starch-based hemostatic material is a hydrogel dosage form formedby a modified starch solution under the catalysis of hydrogen peroxide and catalase. The preparation reaction is carried out under homogeneous conditions, and the problems of high reaction conditionsand low degree of substitution in previous heterogeneous reactions are solved. The preparation process is simple and a preparation cycle is short. The prepared starch-based hemostatic gel can rapidlygelate in case of wound and effectively block the wound, then adheres to activate blood cells and coagulation factors, and then activates a coagulation system, so as to achieve the rapid time series hemostatic effect and promote the wound healing effect. The starch-based hemostatic material is a hemostatic material with broad application prospects.

Description

Technical field [0001] The present invention belongs to the field of biomedical materials science. Specifically, it is a starch-based gel with sequential hemostatic effects, capable of successively realizing the effects of wound closure and accelerating blood coagulation, and a preparation method thereof, and solves the problem of stickiness of existing starch-based hemostatic materials. A defect that is poorly attached and easily washed away by blood flow. Background technique [0002] Bleeding is one of the most common injuries on the battlefield and various accident scenes. Therefore, effective control of bleeding is the key to reducing mortality, reducing complications and winning rescue time for the wounded. Due to the deep wounds and the large amount of bleeding that are common in the scene such as penetrating wounds, irregular wound shapes, and arterial ruptures, general hemostatic materials are difficult to effectively seal the wound, and the hemostatic effect is not idea...

AI Technical Summary

Problems solved by technology

[0004] 1) Poor adhesion: The material initially "floats" on the upper layer of blood, and it is difficult to produce immediate and tight adhesion with the wound surface. It needs to be pressed with external force (gauze) for a period of time to exert its hemostatic effect

"Floating" microspheres are difficult to exert hemostatic effect, and are often carried away by the blood flow and even cause life-threatening

[0005] 2) Easy to fall off: the formed blood clot is not soft enough, and it is easy to fall off when washed by the blood flow, destroying the new tissue of the wound surface, and there is a hidden danger of secondary bleeding and infection, which is not conducive to wound healing

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