Medical periosteum scaffold loaded with ions and geometric pattern signals, and construction method thereof

A technology of geometric patterns and construction methods, applied in medical science, tissue regeneration, prostheses, etc., can solve the problems of unable to meet the needs of clinical bone injury repair, unsatisfactory treatment effect, single function of artificial periosteum, etc. It is not easy to break and promotes synergistic regeneration.

Active Publication Date: 2019-12-20
HUNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] In order to solve the technical problems that the existing artificial periosteum has a single design function, cannot meet the needs of clinical bone injury repair, and leads to unsatisfactory treatment effects, the purpose of the present invention is to provide a novel design and process that uses ion and geometric pattern signals to jointly construct A simple and operable medical periosteum scaffold, which can realize the construction of a bionic natural periosteum scaffold by combining ionic and geometric pattern signals, obtain mechanics similar to natural periosteum, induce bone component regeneration and structural reconstruction, induce angiogenesis and inhibit bacteria The function of proliferation helps the bone tissue repair and functional stability of the injured part to rebuild

Method used

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  • Medical periosteum scaffold loaded with ions and geometric pattern signals, and construction method thereof
  • Medical periosteum scaffold loaded with ions and geometric pattern signals, and construction method thereof
  • Medical periosteum scaffold loaded with ions and geometric pattern signals, and construction method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] A biomimetic medical periosteum scaffold constructed synergistically with ion and geometric pattern signals is prepared by the following method:

[0050] The first step: the preparation of the intermediate fiber layer (fiber support skeleton)

[0051] According to the design, 1g of PCL was weighed and added to the experimental bottle, 3.5ml of dichloromethane and 1.5ml of ethanol were added, and the PCL direct writing solution was formed after fully dissolving for 6 hours. Set the near-field electrofluidic direct writing parameters as solution flow rate 100 μl / min, needle tip-collecting plate distance 2 mm, voltage 4 kV, direct writing needle inner diameter 0.52 mm direct writing platform moving speed 1 (vertical and stretching direction) 20 mm / s, direct writing Writing platform moving speed 2 (parallel and stretching direction) 60mm / s. Design the direct writing pattern as a straight line grid pattern (area: 70×70cm 2 ), and add the direct-writing solution into the mi...

Embodiment 2

[0059] The first step: the preparation of the intermediate fiber layer (fiber support skeleton)

[0060] According to the design, 1.25g of PCL was weighed and added to the experimental bottle, 4.0ml of dichloromethane and 1.0ml of ethanol were added, and the PCL direct writing solution was formed after fully dissolving for 6 hours. Set the near-field electrofluid direct writing parameters as solution flow rate 100 μl / min, needle tip-collecting plate distance 2 mm, voltage 4 kV, direct writing needle inner diameter 0.52 mm, direct writing platform moving speed 1 (vertical and stretching direction) 20 mm / s, Direct writing platform moving speed 2 (parallel and stretching direction) 60mm / s. Design the direct writing pattern as a 30° zigzag grid pattern (area: 70×70cm 2 ), and add the direct-writing solution into the microinjection pump, and the direct-writing fibers support the skeleton.

[0061] The second step: preparation of inner surface fiber layer (geometric pattern signal...

Embodiment 3

[0068] The first step: the preparation of the intermediate fiber layer (fiber support skeleton)

[0069] According to the design, 0.75g of PCL was weighed and added to the experimental bottle, 4.5ml of dichloromethane and 0.5ml of ethanol were added, and the PCL direct writing solution was formed after fully dissolving for 6 hours. Set the near-field electrofluid direct writing parameters as solution flow rate 100 μl / min, needle tip-collecting plate distance 2 mm, voltage 4 kV, direct writing needle diameter 0.52 mm, direct writing platform moving speed 1 (vertical and stretching direction) 20 mm / s, direct writing platform Writing platform moving speed 2 (parallel and stretching direction) 60mm / s. Design the direct writing pattern as a 60° zigzag grid pattern (area: 70×70cm 2 ), and add the direct-writing solution into the microinjection pump, and the direct-writing fibers support the skeleton.

[0070] The second step: preparation of inner surface fiber layer (geometric pat...

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Abstract

The present invention discloses a medical periosteum scaffold cooperatively constructed by ions and geometric pattern signals, and a construction method thereof. The medical periosteum scaffold comprises an inner surface fiber layer, an intermediate fiber layer and an outer surface fiber layer; the inner surface fiber layer is composed of wave-shaped, oriented and arranged loose porous fibers anda degradable and stretchable high polymer material, and provides geometric pattern signal delivery for the periosteum scaffold; the intermediate fiber layer is composed of latticed fibers and a degradable and stretchable high polymer material, and provides mechanical support for the periosteum scaffold; and outer surface fiber layer is composed of disordered and compact composite fibers and a degradable high polymer material and ion-doped biological ceramic micro-nano particles, and provides ion signal delivery for the periosteum scaffold. The construction of the bionic natural periosteum scaffold can be realized by combining the ions and geometric pattern signals, and the medical periosteum scaffold obtains functions of mechanics similar to natural periosteum, induction of bone componentregeneration and structure reconstruction, induction of angiogenesis and inhibition of bacterial proliferation, and helps injured part bone tissue repair and function stable reconstruction.

Description

technical field [0001] The invention relates to a bionic medical periosteum support and a construction method thereof, in particular to a medical periosteum support which can promote the growth of bone tissue and a construction method thereof which is co-constructed by ion and geometric pattern signals, and belongs to the technical field of biomedical materials. Background technique [0002] Scaffold is an important functional material in the repair of clinical bone tissue injury. However, current scaffold materials lack the ability to guide the formation of new bone components and structures at the site of bone tissue damage. In the human body, the periosteum is a dense tissue that wraps the outer surface of the bone and is mainly composed of an outer collagenous fibrous layer (rich in fibroblasts and microvessels) and an inner layer of osteoblasts (storage for bone growth, healing, and remodeling). Progenitor cells) provide different types of necessary cells for bone tiss...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/18A61L27/46A61L27/50A61L27/54A61L27/56A61L27/58
CPCA61L27/18A61L27/46A61L27/50A61L27/54A61L27/56A61L27/58A61L2300/102A61L2300/404A61L2300/412A61L2300/604A61L2430/24C08L77/02
Inventor 王祖勇章万奇吝楠马超
Owner HUNAN UNIV
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