Medical periosteum scaffold loaded with ions and geometric pattern signals, and construction method thereof

Abstract

The present invention discloses a medical periosteum scaffold cooperatively constructed by ions and geometric pattern signals, and a construction method thereof. The medical periosteum scaffold comprises an inner surface fiber layer, an intermediate fiber layer and an outer surface fiber layer; the inner surface fiber layer is composed of wave-shaped, oriented and arranged loose porous fibers anda degradable and stretchable high polymer material, and provides geometric pattern signal delivery for the periosteum scaffold; the intermediate fiber layer is composed of latticed fibers and a degradable and stretchable high polymer material, and provides mechanical support for the periosteum scaffold; and outer surface fiber layer is composed of disordered and compact composite fibers and a degradable high polymer material and ion-doped biological ceramic micro-nano particles, and provides ion signal delivery for the periosteum scaffold. The construction of the bionic natural periosteum scaffold can be realized by combining the ions and geometric pattern signals, and the medical periosteum scaffold obtains functions of mechanics similar to natural periosteum, induction of bone componentregeneration and structure reconstruction, induction of angiogenesis and inhibition of bacterial proliferation, and helps injured part bone tissue repair and function stable reconstruction.

Description

technical field

[0001] The invention relates to a bionic medical periosteum support and a construction method thereof, in particular to a medical periosteum support which can promote the growth of bone tissue and a construction method thereof which is co-constructed by ion and geometric pattern signals, and belongs to the technical field of biomedical materials. Background technique

[0002] Scaffold is an important functional material in the repair of clinical bone tissue injury. However, current scaffold materials lack the ability to guide the formation of new bone components and structures at the site of bone tissue damage. In the human body, the periosteum is a dense tissue that wraps the outer surface of the bone and is mainly composed of an outer collagenous fibrous layer (rich in fibroblasts and microvessels) and an inner layer of osteoblasts (storage for bone growth, healing, and remodeling). Progenitor cells) provide different types of necessary cells for bone tiss...

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