Method for synthesizing quinoxaline compounds by double-protein catalytic cascade reaction

A cascade reaction and compound technology, applied in the field of biocatalytic synthesis, can solve the problems of too many synthesis steps and insufficient environmental protection, and achieve the effects of simple process, reduced separation and purification steps, and reduced use.
CN110592157AActive Publication Date: 2019-12-20JILIN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JILIN UNIV
Publication Date
2019-12-20

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Abstract

The invention relates to the technical field of biological catalytic synthesis and particularly discloses a method for synthesizing quinoxaline compounds by a double-protein catalytic cascade reaction. The method comprises the steps as follows: a beta-keto ester compound, substituted o-phenylenediamine and methylphenylsulfonyl azido are taken as reactants to be dissolved in a solvent, a catalyst and a surfactant are added, the mixture is stirred to react to produce a product, and the product is sequentially dried, concentrated and purified, wherein the solvent is water, and the catalyst is procine pancreaslipase (PPL) and hemoglobin from bovine blood (HbBv). The process is convenient, a heme protein catalytic carbene reaction and a lipase protein catalytic reaction are coupled to constructa green method for synthesizing quinoxaline compound by double proteins by a one-pot method, the target product can be rapidly and conveniently synthesized, meanwhile, synthesis is completed in water, and the problems that the existing quinoxaline compound preparation method comprises more synthesis steps and is not green and environmentally friendly enough are solved.
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Description

technical field

[0001] The invention relates to the technical field of biocatalytic synthesis, in particular to a method for synthesizing quinoxaline compounds through double protein catalytic cascade reaction. Background technique

[0002] Quinoxaline is an important fine chemical intermediate, which is widely used in pesticide, pharmaceutical and other industries, and has certain importance and practicability. Among them, quinoxaline derivatives (quinoxaline compounds), as a class of important benzopyrazine heterocyclic compounds, have a wide range of biological activities (such as antitumor, antiviral, antibacterial, anti-inflammatory, anti-HIV, etc. activity), it can be used as a backbone molecule in pharmaceutical preparation. In addition, quinoxaline compounds can also be used as synthetic intermediates for products such as fuels, organic semiconductors, and solar cells.

[0003] At present, there are many chemical methods to synthesize quinoxaline compounds. Among ...

Claims

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