Synthetic method for 3,4-dihydroxybenzaldehyde

Abstract

The invention discloses a synthetic method for 3,4-dihydroxybenzaldehyde. The method comprises the following steps: firstly, dissolving p-hydroxy benzaldehyde by using an organic solution, controllingthe temperature, slowly adding bromine dropwise, performing a reaction for a period of time, performing filtration, performing recrystallization, and performing drying to obtain 3-bromo-4-hydroxybenzaldehyde; and adding an alkali solution to dissolve the 3-bromo-4-hydroxybenzaldehyde and a catalyst, adding the obtained solution into an autoclave, performing heating to 150 DEG C, performing a reaction under stirring for 1 h, performing filtration, adjusting the pH value of the filtrate by using dilute hydrochloric acid, performing a reaction under stirring for 0.5 h, performing extraction twice by using an organic solution, combining the organic phases, performing drying by using saturated brine, and evaporating a solvent to obtain the 3,4-dihydroxybenzaldehyde. The raw materials are easyto obtain, and the method shortens the reaction route, increases the overall yield, is simple to operate and easy to implement, has low costs, and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of compound synthesis, in particular to a synthesis method of 3,4-dihydroxybenzaldehyde. Background technique [0002] 3,4-Dihydroxybenzaldehyde is an important organic synthesis raw material and pharmaceutical intermediate, which can condense with compounds containing active hydrogen and ammonia. There are many traditional methods for synthesizing 3,4-dihydroxybenzaldehyde, but these methods have many synthetic steps and are relatively cumbersome, and the raw materials are all toxic. At present, the main source of 3,4-dihydroxybenzaldehyde in my country is from import. Contents of the invention [0003] The purpose of the present invention is to solve the problems of cumbersome steps and toxic raw materials in the existing traditional synthesis method, and provide a safe and non-toxic synthesis method of 3,4-dihydroxybenzaldehyde. [0004] The present invention is achieved through the following technical solutions...

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to solve the problems of cumbersome steps and toxic raw materials in the existing traditional synthetic method, and provide a safe and non-toxic 3,4-dihydroxybenzaldehyde synthetic method