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Hydrogel, preparation method thereof, biomembrane fixing device and application of hydrogel

A technology of hydrogel and derivatives, applied in medical science, surgery, bandages, etc., can solve the problems of amniotic membrane or other biofilm damage, unfavorable amnion biofilm replacement, and inability to fix, so as to alleviate the easy breeding of bacteria and avoid Easy to breed bacteria, soft texture effect

Pending Publication Date: 2020-01-03
宁波瑞瑧生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current amniotic membrane coverage and amniotic membrane transplantation often use sutures. This method of amniotic membrane fixation will inevitably damage the ocular surface, and the suture process will easily cause damage to the amniotic membrane or other biological membranes, which is not conducive to the replacement of amniotic membranes and other biological membranes.
At present, metals (such as nickel-titanium alloys, silver, etc.) and plexiglass are also used as biofilm fixing devices on the market. Although these materials have a good supporting effect and high hardness and are not easy to deform, they have obvious foreign body sensation, which can easily cause wearing discomfort and biofilm Displacement, can't play a good role in fixing

Method used

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  • Hydrogel, preparation method thereof, biomembrane fixing device and application of hydrogel
  • Hydrogel, preparation method thereof, biomembrane fixing device and application of hydrogel
  • Hydrogel, preparation method thereof, biomembrane fixing device and application of hydrogel

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preparation example Construction

[0070] In some preferred embodiments, the preparation method includes the following steps:

[0071] (a) Put the synthetic monomer, solubilizer, crosslinking agent, initiator, catalyst and water into the mold after mixing;

[0072] (b) reacting the mold in step (a) for 24 hours under the condition of 20-100° C., and curing and forming;

[0073] (c) Take out the shaped hydrogel, soak and wash it with 30% ethanol solution for 3 days to remove unreacted monomer, initiator and catalyst in the sample;

[0074] (d) Vacuum drying for 24 hours to obtain a dry hydrogel.

[0075] According to another aspect of the present invention, the present invention also provides a biofilm immobilization device, which is mainly prepared from the above-mentioned hydrogel, or mainly prepared by the above-mentioned preparation method. The biofilm fixation device of the present invention refers to a device for fixing the biofilm on the affected part, mainly through the above-mentioned hydrogel part co...

Embodiment 1

[0082] This embodiment provides a kind of hydrogel, in terms of the mass ratio of each raw material to water, the consumption of each raw material is as follows:

[0083] HEMA: water is 50:3;

[0084] Solubilizer: water is 5:1;

[0085] Cross-linking agent: water is 1:10;

[0086] Initiator: water is 2:3;

[0087] Catalyst: water is 1:3.

[0088] Wherein, the solubilizer is glycerin, the crosslinking agent is polyethylene glycol diacrylate, the initiator is ammonium persulfate, and the catalyst is N,N,N',N'-tetramethylethylenediamine.

[0089] The preparation method is as follows:

[0090] (1) Fully stir and mix HEMA, glycerin, water, crosslinking agent, initiator and catalyst and inject them into the polypropylene mould;

[0091] (2) Put the injected polypropylene mold into an oven at 60°C, react for 24 hours, and solidify and form;

[0092] (3) Take out the formed hydrogel, soak and wash with ethanol aqueous solution (the mass ratio of ethanol to water is 3:7, so that th...

Embodiment 2

[0096] This embodiment provides a kind of hydrogel, in terms of the mass ratio of each raw material to water, the consumption of each raw material is as follows:

[0097] HEMA: water is 50:3;

[0098] Solubilizer: water is 10:3;

[0099] Cross-linking agent: water is 1:15;

[0100] Initiator: water is 2:3;

[0101] Catalyst: water is 2:3.

[0102] Wherein, the solubilizer is glycerin, the crosslinking agent is ethylene glycol dimethacrylate, the initiator is ammonium persulfate, and the catalyst is N,N,N',N'-tetramethylethylenediamine.

[0103] The preparation method is as follows:

[0104] (1) Fully stir and mix HEMA, glycerin, water, crosslinking agent, initiator and catalyst and inject them into the polypropylene mould;

[0105] (2) Put the injected polypropylene mold into an oven at 50°C, react for 24 hours, and solidify and form;

[0106] (3) Take out the formed hydrogel, soak and wash with ethanol aqueous solution (the mass ratio of ethanol to water is 3:7, so that...

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Abstract

The invention provides a hydrogel, a preparation method thereof, a biomembrane fixing device and an application of the hydrogel, and relates to the technical field of biological materials. Raw materials of the hydrogel comprise a synthetic monomer, a solubilizer, a cross-linking agent, an initiator, a catalyst and water, wherein the synthetic monomer comprises hydroxyethyl methacrylate (HEMA) and / or a derivative of HEMA. The usage amount the raw materials are as follows: the mass ratio of the synthetic monomer to water is (0.5-20):1; the mass ratio of the solubilizer to water is (0.1-10):1; the mass ratio of the cross-linking agent to water is (0.001-0.5):1; the mass ratio of the initiator to water is (0.05-2):1; and the mass ratio of the catalyst to water is (0.05-2):1. The hydrogel has good biocompatibility, stability and hydrophilicity, excellent water absorption and swelling performance, good optical performance, high mechanical performance and soft texture. The biomembrane fixingdevice prepared by using the hydrogel has small foreign body feeling and is comfortable to wear.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a hydrogel, a preparation method thereof, a biofilm fixing device and applications. Background technique [0002] At present, the biomembrane used for the treatment of ocular surface injury is mainly amnion, and also includes other membranes with cells. With the continuous research on the biology and chemistry of the amniotic membrane, the amniotic membrane, as the last basement membrane of the human body, has shown great clinical application value. As an important support, amniotic membrane can restore the normal epithelial phenotype of cornea and conjunctiva, promote the migration of epithelial cells, strengthen the adhesion between epithelial and basal layers, promote the differentiation of epithelial cells, and inhibit the apoptosis of epithelial cells. However, the current amniotic membrane coverage and amniotic membrane transplantation often use sutures. This method o...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08F220/20C08F220/18A61L26/00A61L31/04A61L31/14C08L33/14C08L33/10
CPCC08J3/075C08F220/20C08F220/18A61L31/048A61L31/145A61L26/0014A61L26/008C08J2333/14C08J2333/10C08L33/14C08L33/10
Inventor 李锐聪谭睿哲梁丽金邹鹏陈琦
Owner 宁波瑞瑧生物科技有限公司
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