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Drug composition containing rosuvastatin calcium and preparation method and application thereof

A technology of rosuvastatin calcium and its composition, which is applied in the direction of drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problem of no type I allergy curative effect, and achieve excellent curative effect and reasonable prescription , the effect of broad application prospects

Inactive Publication Date: 2020-01-07
HEILONGJIANG ZBD PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no product with excellent curative effect on type Ⅰ allergy on the market. In view of this, this patent is proposed

Method used

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  • Drug composition containing rosuvastatin calcium and preparation method and application thereof
  • Drug composition containing rosuvastatin calcium and preparation method and application thereof
  • Drug composition containing rosuvastatin calcium and preparation method and application thereof

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preparation example Construction

[0024] This embodiment also provides a method for preparing the above-mentioned first composition and second composition, which includes:

[0025] Step S1: In parts by weight, microcrystalline cellulose, lactose, tricalcium phosphate and part of cross-linked povidone are mixed, granulated by wet method, and granulated with a 20-40 mesh sieve after drying to obtain blank granules;

[0026] Further, it also includes the step of uniformly mixing 1800-4200 parts by weight of seaweed polysaccharide, lactose, microcrystalline cellulose, tricalcium phosphate and partially cross-linked povidone, and performing wet granulation.

[0027] Furthermore, the drying temperature after granulation by the manufacturing method is 55-65 degreeC.

[0028] Step S2: mixing the blank granules with rosuvastatin calcium, the remaining crospovidone and magnesium stearate to prepare the preparation.

[0029] Further, the raw material of rosuvastatin calcium is passed through an 80-mesh sieve; the lactos...

Embodiment 1

[0036] The present embodiment provides a kind of pharmaceutical composition, and its composition and dosage are as shown in the following table:

[0037]

[0038] The preparation method of this pharmaceutical composition comprises:

[0039] a. Making soft materials and granulating: take by weighing microcrystalline cellulose, lactose (200 mesh), tricalcium phosphate, and cross-linked povidone, mix evenly, add an appropriate amount of wetting agent (ethanol-water mixed solution) to prepare Soft material, 30 mesh sieve nylon granulation;

[0040] b. Drying and sizing: Boiling drying at 60°C, sizing with a 30-mesh nylon sieve to obtain blank granules;

[0041] c. Total blending: according to the amount of blank granules, add the raw material drug and crospovidone in the prescribed proportion, mix evenly, then add the magnesium stearate in the prescribed amount, and mix evenly;

[0042] d. Tablet compression: Use a tablet press machine with a diameter of 7 mm to punch the ble...

Embodiment 2

[0045] The present embodiment provides a kind of pharmaceutical composition, and its composition and dosage are as shown in the following table:

[0046]

[0047]

[0048] The preparation method of this pharmaceutical composition comprises:

[0049] a. Making soft materials and granulating: take by weighing microcrystalline cellulose, lactose (200 mesh), tricalcium phosphate, and cross-linked povidone, mix evenly, add an appropriate amount of wetting agent (ethanol-water mixed solution) to prepare Soft material, 20 mesh sieve nylon granulation;

[0050] b. Drying and sizing: Boiling drying at 55°C, sizing with a 20-mesh nylon sieve to obtain blank granules;

[0051] c. Total blending: according to the amount of blank granules, add the raw material drug and crospovidone in the prescribed proportion, mix evenly, then add the magnesium stearate in the prescribed amount, and mix evenly;

[0052] d. Tablet compression: use a tablet press machine to punch the blended granule...

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Abstract

The invention provides a drug composition containing rosuvastatin calcium and a preparation method and application thereof, and belongs to the field of drugs. The drug composition is prepared from therosuvastatin calcium, lactose, microcrystalline cellulose, tricalcium phosphate, magnesium stearate and polyvinylpolypyrrolidone. The preparation method of the drug composition comprises the steps: in parts by weight, the microcrystalline cellulose, the lactose, the tricalcium phosphate and part of the polyvinylpolypyrrolidone are mixed, wet granulation is conducted, after drying, granulation isconducted through a screen of 20-40 meshes, and blank particles are obtained; and then the blank particles are mixed with the rosuvastatin calcium, the remaining polyvinylpolypyrrolidone and the magnesium stearate for preparation. The drug composition is reasonable in component, and through research, the inventor finds that the drug composition is excellent in curative effect on an I-type allergicdisease, can be used for preparing drugs for preventing or treating the I-type allergic disease, and is wide in application prospect.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a pharmaceutical composition containing rosuvastatin calcium, a preparation method and application thereof. Background technique [0002] Type I allergy, also known as anaphylaxis, is the most common clinical type, and its characteristics are: mediated by IgE, mast cells and basophils and other effector cells participate in the reaction by releasing bioactive mediators; it occurs quickly and subsides It is also fast; often manifested as physiological dysfunction without serious tissue damage; there are obvious individual differences and genetic predispositions. [0003] After allergens enter the body, B cells are induced to produce IgE antibodies. IgE has a high affinity with target cells and is firmly adsorbed on the surface of mast cells and basophils. When the same antigen enters the sensitized body again and combines with IgE antibody, it will trigger a series of biochemical reacti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/505A61K31/737A61K9/28A61K47/38A61P37/08
CPCA61K31/505A61K31/737A61K9/286A61K47/38A61P37/08A61K2300/00
Inventor 方同华许照芹崔玉海王维龙
Owner HEILONGJIANG ZBD PHARMA
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