A device and method for regulating the morphology and pore structure of microparticles
A technology of micro-particles and morphology, applied in chemical instruments and methods, chemical/physical/physical-chemical processes of energy application, chemical/physical/physical-chemical processes, etc. and the uniformity and controllability of the structure, the inability to achieve precise and controllable control of micro-particles, the difficulty in ensuring the conditions of temperature, mixing, and reaction, etc., to achieve the effect of controllable morphology/pore structure, simple and feasible structure, and universality.
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Embodiment 1
[0106] This embodiment provides a device for regulating the morphology and structure of microparticles, which is based on an ultrasonically coupled microchannel reactor, with a structure such as figure 1 As shown, including droplet generation area, ultrasonic induction area and aging area;
[0107] The channel in the droplet generation area has a width of 50 microns and a height of 50 microns, which is a flow-focused micro channel, including two dispersed phase channels and two continuous phase channels;
[0108] The channel width of the ultrasonic induction zone is 300 micrometers, the height is 300 micrometers, and the length is 10 centimeters. The annular channel structure is adopted to make the channel completely on the piezoelectric ceramic sheet.
[0109] The microchannel reactor provided in this example can be used to prepare monodisperse polyvinyl alcohol microspheres, but is not limited thereto. The following steps can be followed when preparing monodisperse polyvin...
Embodiment 2
[0117] The size of the channel in the droplet generation area is 100 microns, and the formulation of the reagent is the same as in Example 1. The flow rate of the first dispersed phase and the second dispersed phase solution is set to be 0.5mL / h, and the flow rate of the continuous phase solution is 1mL / h. for 210 micron droplets.
[0118] The channel size and structure of the induction zone are the same as in Example 1. The frequency of the transducer is 28kHz, and the power is 560W.
[0119] After the product is washed and separated, PVA microparticles are obtained, and the appearance is as follows: image 3 As shown, due to the enhanced ultrasonic intensity and perhaps the size of the droplet is in the resonance range, the stretching vibration of the droplet is strong, the deformation increases, and the microparticles are spindle-shaped. In addition, it can be seen from the cross-sectional view of the micro-particles that the interior of the micro-particles has a honeycomb...
Embodiment 3
[0121] The droplet generation channel size is 100 microns, the concentration of polyvinyl alcohol is 3wt%, the concentration of glutaraldehyde is 0.4moL / L, the concentration of hydrochloric acid aqueous solution is 0.6mol / L, and the oil phase adopts liquid paraffin containing 2wt% EM90.
[0122] Set the flow rate of the first dispersed phase and the second dispersed phase solution to 0.5mL / h, and the flow rate of the continuous phase solution to 1mL / h to generate droplets with a size of 210 microns.
[0123] The channel size and structure of the induction zone are the same as in Example 1, the frequency of the transducer is 68kHz, and the power is 400W.
[0124] After the product is washed and separated, PVA microparticles are obtained, and the appearance is as follows: Figure 4 As shown, compared with Example 2, the morphology of the microparticles basically remains spindle-shaped, but the size uniformity becomes worse, and there are large bubble pits on the surface of some ...
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Abstract
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