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Glycosaminoglycan-producing promoter and composition for promoting glycosaminoglycan production

A technology of glucan and glucosamine, which is applied in the field of glucosamine-based glucan production accelerators and glucosamine-based glucan production-promoting compositions, and can solve problems such as insufficient effect and practical application.

Pending Publication Date: 2020-01-17
株式会社力森诺科
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] As agents for promoting the production of glucosaminoglycans, milk-based proteins (Patent Document 1), peptides or derivatives thereof, or salts thereof (Patent Document 2), Lilium candidum extract and glucosamine have been known so far. (Patent Document 3), lysophospholipids (Non-Patent Document 1), Aloe arborescens extract (Non-Patent Document 2), polystyrene derivatives with sugar side chains (Non-Patent Document 3), but it is only helpful Agents for promoting the production of hyaluronic acid in glucosaminoglycans, etc., their effects and practical applications are still insufficient

Method used

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  • Glycosaminoglycan-producing promoter and composition for promoting glycosaminoglycan production
  • Glycosaminoglycan-producing promoter and composition for promoting glycosaminoglycan production

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0096] In one embodiment, the present invention provides a glucosaminoglycan production-promoting product comprising a step of administering to mammals an inositol derivative obtained by binding sugars (monosaccharides, oligosaccharides) to inositol. method.

[0097] In one embodiment, the present invention provides a sulfated glucosaminoglycan comprising a step of administering to a mammal an inositol derivative obtained by binding sugars (monosaccharides, oligosaccharides) to inositol. (particularly, N-sulfated glucosaminoglycans) production methods.

[0098] In one embodiment, the present invention provides a method for promoting production of hyaluronic acid including the step of administering to mammals an inositol derivative obtained by binding sugars (monosaccharides, oligosaccharides) to inositol.

[0099] In one embodiment, the present invention provides a glycosaminoglycan deficiency caused by glucosaminoglycan deficiency, including the step of administering to mamm...

experiment example 1

[0117] (Production of inositol derivatives)

[0118] Myo-inositol and β-cyclodextrin are reacted in the presence of cyclodextrin glucosyltransferase to produce an inositol derivative in which glucose or an oligosaccharide having glucose as a monosaccharide unit is bound to myo-inositol. The prepared inositol derivative was analyzed by liquid chromatography-mass spectrometry (LC-MS). As a result, the ratio of molecules with one glucose chain bound to the glucose chain of myo-inositol was 12% by mass, and bound to The ratio of molecules with 2 glucose in the glucose chain of myo-inositol was 30% by mass, and the ratio of molecules with 3 glucose in the glucose chain of myo-inositol was 9% by mass. The ratio of molecules having 4 glucose chains in the glucose chain was 12% by mass, and the ratio of molecules having 5 glucose chains bound to myo-inositol was 2% by mass.

experiment example 2

[0120] (Preparation of medium and culture of cells)

[0121] As cells, normal human fibroblasts (RIKEN Bioresource Center) treated with hydrogen peroxide were used. In addition, as a medium, Dulbecco's Modified Eagle (DMEM) medium containing 10% fetal bovine serum was used.

[0122] The inositol derivative produced in Experimental Example 1 was dissolved in purified water to a final concentration of 10 -4 It was added to the medium in the form of w / v% to prepare a medium (Example 1). In addition, as a comparative example, a medium in which myo-inositol was added instead of the inositol derivative was prepared (comparative example 1).

[0123] Furthermore, as a control, a culture medium to which purified water was added instead of the inositol derivative was prepared (comparative example). With these media, cells were incubated at 37°C, 5% CO 2 Incubate under atmosphere for 72 hours.

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Abstract

Provided is a glycosaminoglycan-producing promoter containing, as an active ingredient, an inositol derivative in which sugar binds to inositol. Also provided is a composition for promoting glycosaminoglycan production, the composition containing: said glycosaminoglycan-producing promoter; and a pharmaceutically acceptable carrier.

Description

technical field [0001] The present invention relates to a glucosaminoglycan production-promoting agent and a glucosaminoglycan production-promoting composition. [0002] This application claims priority based on Japanese Patent Application No. 2017-110803 for which it applied in Japan on June 5, 2017, and uses the content here. Background technique [0003] Glucosaminoglycan is an acidic mucopolysaccharide composed of repeated disaccharide structures in which uronic acid or galactose is combined with amino sugar. Glucosaminoglycans are classified according to the type of saccharides that constitute them, and include hyaluronic acid, keratan sulfate, heparan sulfate, heparin, chondroitin, chondroitin sulfate, and dermatan sulfate. They are present as a matrix (extracellular matrix) between fibers and cells of tissues in various parts of a living body. [0004] Glucosaminoglycan is a glycoprotein called proteoglycan, a molecule formed by the covalent combination of sugar cha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7034A61P17/02A61P17/16A61P19/02A61P43/00A61Q19/00A61K8/60A61K8/73A61K31/716
CPCA61K8/60A61K8/73A61K31/7034A61K31/716A61P17/02A61P19/02A61Q19/00A61K8/738A61K8/345A61Q19/08A61P29/00
Inventor 中上夕子三品菜津乃加藤咏子
Owner 株式会社力森诺科
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