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Quality detection method for traditional Chinese medicine pediatric cold-relieving granules

A detection method, the technology of Xiaoer Jiegan, which is applied in the field of medicine, can solve the problems of inability to measure the content of six components in Xiaoer Jiegan Granules, the inapplicability of Xiaoer Jiegan Granules, and the difficulty of detection operation, so as to achieve a comprehensive and practical evaluation The effect of high safety, product quality and safety

Active Publication Date: 2020-01-31
SHANDONG MINGREN FURUIDA PHARMA
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AI Technical Summary

Problems solved by technology

[0008] To sum up, the components of traditional Chinese medicine products are diverse and complex, and the evaluation of drug quality by a single component is not accurate, which is not conducive to a comprehensive evaluation of the quality of traditional Chinese medicine. However, the determination of multi-index content requires a large consumption of reference substances, high testing costs, and difficult testing operations.
There is no detection method in the prior art that can realize the one-test and multiple-evaluation method to determine the contents of the six components in Xiaoer Jiegan Granules, and the determination conditions and substances of the other prior art methods are not suitable for Xiaoer Jiegan Grainy

Method used

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  • Quality detection method for traditional Chinese medicine pediatric cold-relieving granules
  • Quality detection method for traditional Chinese medicine pediatric cold-relieving granules
  • Quality detection method for traditional Chinese medicine pediatric cold-relieving granules

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Embodiment 1

[0040] 1. Instruments, reagents and test samples

[0041] Instrument: High performance liquid chromatography: Agilent 1260, G1311C infusion pump, G1329B automatic sampling system, G1315D diode array detector, Waters Empower3 workstation; METTLER TOLEDO XPE205 electronic balance

[0042] Reference substances: baicalin (batch number 110715-201821, purity 95.4%), wogonin (batch number 112002-201702, purity 98.5%), liquiritin (batch number 111610-201607, purity 93.1%), baicalein (batch number 111595-201808 , purity 97.9%), wogonin (batch number 111514-201706, purity 100%), ammonium glycyrrhizinate (batch number 110731-201720, purity 97.7%)

[0043] Test sample: Xiaoer Jiegan Granules (Shandong Mingren Freda Pharmaceutical Co., Ltd.)

[0044]Batch numbers: 18105084, 18105080, 18105083, 18112401, 18112701, 18112901, 20190128, 20190129, 20190130, 19105028, 19105029, 19105030.

[0045] 2. Chromatographic conditions

[0046] Determine according to high performance liquid chromatogra...

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Abstract

The invention relates to a quality detection method for traditional Chinese medicine pediatric cold-relieving granules. According to the invention, the contents of baicalin, wogonoside, baicalein, wogonin, liquiritin and ammonium glycyrrhizinate in the traditional Chinese medicine pediatric cold-relieving granules are determined by high performance liquid chromatography. According to the invention, the separation degree between each to-be-detected component in the chromatogram of a test sample and the adjacent peak is greater than 1.5, and negative control has no interference, so that the quality safety of the granules is further ensured, evaluation is comprehensive, and the detection method has the advantages of high practicability, high operability, cost saving and the like in operation.

Description

technical field [0001] The invention relates to a quality detection method of Xiaoer Jiegan granule, a traditional Chinese medicine, and belongs to the technical field of medicine. Background technique [0002] Xiaoer Jiegan Granules are not included in any pharmacopoeia, and Xiaoer Jiegan Tablets are included in Part One of the Chinese Pharmacopoeia 2015 Edition. It can clear away heat and relieve exterior syndrome, relieve throat and relieve cough. For cold and fever, headache and stuffy nose, cough and sneeze, sore throat. At present, the Pediatric Jiegan preparation is made of the following medicinal materials in the following weight ratio: 830 grams of Daqingye, 415 grams of Bupleurum, 415 grams of Scutellaria, 415 grams of Nepeta, 250 grams of Campanulaceae, and 165 grams of Licorice. Xiao'er Jiegan Granules are favored by patients clinically due to their good effect and remarkable curative effect after clinical verification. [0003] However, the prescription of Xi...

Claims

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Application Information

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IPC IPC(8): G01N30/06G01N30/74
CPCG01N30/06G01N30/74
Inventor 江玉娟吴世德贾美春潘瑞雪李琳王莉米凤雅许敏刘晓彤
Owner SHANDONG MINGREN FURUIDA PHARMA
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