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Bone defect implant, construction method thereof, preparation method thereof, computer readable storage medium and equipment

A construction method and bone defect technology, applied in bone implants, joint implants, joint implants, etc., can solve the problems of drug-resistant bacteria tissue and organ damage, long treatment period, etc.

Inactive Publication Date: 2020-02-07
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing treatment methods have a long cycle and often require secondary or multiple surgeries. Long-term and high-dose antibiotic application can also lead to the emergence of drug-resistant bacteria and damage to tissues and organs.

Method used

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  • Bone defect implant, construction method thereof, preparation method thereof, computer readable storage medium and equipment
  • Bone defect implant, construction method thereof, preparation method thereof, computer readable storage medium and equipment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] figure 1 It is the CT three-dimensional reconstruction diagram of this embodiment.

[0071] A bone defect implant, comprising a bone defect implant body, the contact surface of the bone defect implant body and bone is provided with a fusion surface layer, the fusion surface layer is a porous structure, and the porous structure is The layered structure of several layers, the layered structure of each layer has a plurality of micropores, the micropores of the layers are connected to each other, and has a regular hexahedral porous structure. The rate is 38.9%. The shape of the bone defect implant body and the fusion surface layer is the shape of the patient's bone defect. The material and mass percentage of the bone defect implant are: magnesium 95.5wt%, neodymium 3wt% , Zinc 1wt%, Zirconium 0.5wt%.

[0072] The compressive strength of the bone defect implant was 70MPa, and the elastic modulus was 1.3Gpa.

[0073] A method for preparing a bone defect implant, comprising...

Embodiment 2

[0084] A bone defect implant, comprising a bone defect implant body, the contact surface of the bone defect implant body and bone is provided with a fusion surface layer, the fusion surface layer is a porous structure, and the porous structure is The layered structure of several layers, the layered structure of each layer has multiple micropores, the micropores of the layers are connected to each other, and has a regular square porous structure. The rate is 75.3%. The shape of the bone defect implant body and the fusion surface layer is the shape of the patient's bone defect. The material and mass percentage of the bone defect implant are: magnesium 95.5wt%, neodymium 3wt% , Zinc 1wt%, Zirconium 0.5wt%.

[0085] The compressive strength of the bone defect implant was 34MPa, and the elastic modulus was 0.6Gpa.

[0086] A method for preparing a bone defect implant, comprising:

[0087] 1) Construct and obtain the bone defect implant model according to the construction method o...

Embodiment 3

[0097] A bone defect implant, including a bone defect implant body, the shape of the bone defect implant body is the shape of the patient's bone defect, the material and mass percentage of the bone defect implant: magnesium 96wt%, Neodymium 1wt%, Zinc 2wt%, Zirconium 1wt% (without fusion surface layer).

[0098] The compressive strength of the bone defect implant was 350MPa, and the elastic modulus was 40Gpa.

[0099] A method for preparing a bone defect implant, comprising:

[0100] 1) Construct and obtain the bone defect implant model according to the construction method of the bone defect implant model;

[0101] 11) Construct a three-dimensional bone model;

[0102] The three-dimensional bone model usually includes models of various tissues. For example, the model can include models of tissues such as skin, bones, blood vessels, nerves, and diseased parts (for example, tumors), and the model can reflect the individual (for example, patient) ), it can also reflect the sha...

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Abstract

The invention provides a bone defect implant, a construction method thereof, a preparation method thereof, a computer readable storage medium and equipment. The bone defect implant comprises a bone defect implant body, the shape of the bone defect implant is the shape of a bone defect of a patient, the material of the bone defect implant comprises magnesium metal and second metal, and the second metal is selected from at least one of alkaline earth metal, main group IIIA metal, main group IVA metal and transition metal. The materials of the bone defect implant can be completely degraded, and degradation products of the bone defect implant can be discharged out of a body through urine. Furthermore, no metal artifact exists; compared with stainless steel and titanium alloy, the implant has the advantages that the implant is good in biocompatibility, free of adverse effects on postoperative imaging examination of the patient and good in antibacterial property, the implant can be preparedin a 3D printing mode (such as a selective laser melting technology), the bone defect implant is in the shape of the bone defect of the patient, and the mechanical property and the degradation property of the magnesium alloy can be adjusted by accurately adjusting and controlling the porous structure.

Description

technical field [0001] The invention belongs to the technical field of bone repair, and in particular relates to a bone defect implant, a construction method, a preparation method, a computer-readable storage medium, and a device. Background technique [0002] Osteomyelitis, osteomyelitis combined with bone defect is a thorny problem in orthopedic clinical work. The etiology is complicated and the course of the disease is long. If not treated properly, it can cause deformity, joint ankylosis, pathological fracture, operation failure, amputation and other catastrophic consequences, seriously affecting the quality of life of patients. At present, the treatment of such diseases requires thorough debridement, elimination of dead space and long-term antibiotic treatment. Existing treatment methods have a long cycle and often require secondary operations or multiple operations. Long-term and high-dose antibiotic application can also lead to the emergence of drug-resistant bacteri...

Claims

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Application Information

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IPC IPC(8): A61F2/28A61F2/30
CPCA61F2/28A61F2/30771A61F2/30942A61F2002/2835A61F2002/30784A61F2002/30948A61F2002/3096A61F2002/3097A61F2002/30985A61F2210/0076A61F2310/00041
Inventor 郝永强谢凯王磊姜闻博
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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