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A kind of preparation method of functional compound rgo-ionp-peg

A technology of C18-PMH-PEG and compound, which is applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve the problems of slow reaction rate, long process time, unstable reaction, etc. problems, to achieve the effect of increasing yield, increasing reaction rate and shortening process time

Active Publication Date: 2020-11-10
海南省妇幼保健院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the problem that exists at present is, in obtaining C18-PMH-PEG composite process and the composite of C18-PMH-PEG and RGO-IONP nanocomposite reaction process, often required process time is longer, and its reaction rate is slower. slow, thus resulting in low preparation efficiency for RGO-IONP-PEG nanocomposites; in addition, due to the low rate of grafting reaction between C18-PMH-PEG complexes and RGO-IONP nanocomposites, the reaction is unstable, affecting the Efficient modification of RGO-IONP nanocomposites, which ultimately leads to the problem of low yields of the resulting RGO-IONP-PEG nanofunctional complexes

Method used

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  • A kind of preparation method of functional compound rgo-ionp-peg
  • A kind of preparation method of functional compound rgo-ionp-peg

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Experimental program
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Effect test

Embodiment 1

[0027] Embodiment 1-a preparation method of functional complex RGO-IONP-PEG, comprising the following steps:

[0028] (1) Obtain C18-PMH-PEG complex

[0029] a. Mix 10mg poly(maleic anhydride-1-octadecene) (C18PMH) with 143mgNH 2 -PEG-OCH 3 (5k) was mixed and dissolved in 5ml of dichloromethane solution according to the molar ratio of 1:1, firstly ferric chloride and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC ) combined as a catalyst, the mass ratio of ferric chloride and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) is 1:3, and the dissolving solution is placed at 80 The catalytic reaction was carried out under microwave radiation at ℃, and the initial reaction liquid was obtained after the reaction time of microwave radiation was 4 hours; then 2-(thiophene-2-methyl)phenylboronic acid was added as a catalyst, and the catalytic reaction was continued under microwave radiation at 65°C 4h, obtain reaction solution;

[0030] Wherein, ...

Embodiment 2

[0035] Embodiment 2--a kind of preparation method of functional compound RGO-IONP-PEG, comprises the following steps:

[0036] (1) Obtain C18-PMH-PEG complex

[0037] a. Mix 10mg poly(maleic anhydride-1-octadecene) (C18PMH) with 143mgNH 2 -PEG-OCH 3 (5k) was mixed and dissolved in 5ml of dichloromethane solution according to the molar ratio of 1:1, firstly ferrous nitrate and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC ) combined as a catalyst, the mass ratio of ferrous nitrate and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) is: 1:5, and the dissolving solution is placed at 95 The catalytic reaction was carried out under microwave radiation at ℃, and the initial reaction liquid was obtained after the reaction time of microwave radiation was 3h; then 2-(thiophene-2-methyl)phenylboronic acid was added as a catalyst, and the catalytic reaction was continued under microwave radiation at 45℃ 7h, obtain reaction solution;

[0038] Where...

Embodiment 3

[0043] Embodiment 3-a preparation method of functional complex RGO-IONP-PEG, comprising the following steps:

[0044] (1) Obtain C18-PMH-PEG complex

[0045] a. Mix 10mg poly(maleic anhydride-1-octadecene) (C18PMH) with 143mgNH 2 -PEG-OCH 3 (5k) is mixed and dissolved in 5ml dichloromethane solution according to molar ratio 1:1, at first adopt ferrous chloride and 1-(3-dimethylaminopropyl group)-3-ethylcarbodiimide hydrochloride ( EDC) is combined as catalyzer, and the mass ratio of ferrous chloride and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) is: 1:4, and dissolving solution is placed Catalytic reaction was carried out under microwave radiation at 85°C, and the reaction time was 4h under microwave radiation to obtain the initial reaction solution; then 2-(thiophene-2-methyl)phenylboronic acid was added as a catalyst, and continued under microwave radiation at 55°C Catalyzed reaction 5h, obtain reaction solution;

[0046] Wherein, the mass ratio of...

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Abstract

The invention provides a method for preparing a functional complex RGO-IONP-PEG (reduced graphene oxide-iron oxide nanoparticle-polyethylene glycol). The method comprises the following steps: (1) dissolving C18PMH with NH2-PEG-OCH3 into a dichloromethane solution, adding metal iron salt and EDC (1-(3-dimethylamino propyl)-3-ethyl carbodiimide hydrochloride), performing a microwave radiation catalytic reaction, adding 2-(thiophene-2-methyl) phenylboric acid, performing a microwave radiation catalytic reaction, transferring the solution to a constant temperature water bath of 50-65 DEG C, performing stirring, performing blowing drying so as to obtain a crude product of solid powder, and performing dialysis so as to obtain a C18-PMH-PEG complex; and (2) mixing an RGO-IONP nano complex with the C18-PMH-PEG complex, performing stirring for 3-5 minutes, performing ultrasonic treatment, adding 2-chlorophenyl boric acid, performing a microwave radiation catalytic reaction, performing centrifugation, and performing washing so as to obtain the complex provided by the invention. By adopting the method, the overall process time can be greatly shortened, in addition, the yields of the C18-PMH-PEG complex and the RGO-IONP-PEG nano functional complex can be increased.

Description

technical field [0001] The invention relates to the technical field of composite materials, in particular to a preparation method of a functional composite RGO-IONP-PEG. Background technique [0002] In the existing preparation process of RGO-IONP-PEG nano functional composites, polyethylene glycol is usually used to modify the reduced graphene and ferric oxide nanocomposites (RGO-IONP nanocomposites) to improve the RGO-IONP - Stability and biocompatibility of PEG nanofunctional complexes in physiological environments. In order to effectively modify RGO-IONP nanocomposites, the carboxyl groups on poly(maleic anhydride-1-octadecene) (C18-PMH) are usually firstly grafted directly with polyethylene glycol (PEG) to prepare The amphiphilic C18-PMH-PEG complex is obtained, and then the C18-PMH-PEG complex is ultrasonically mixed with the RGO-IONP nanocomposite for grafting reaction, thereby obtaining the RGO-IONP-PEG nanofunctional complex. But the problem that exists at present...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G83/00A61K41/00A61K47/60A61P35/00
CPCA61K41/0052A61K47/60A61P35/00C08G83/001
Inventor 战跃福吴烨华王毅翔鲁宏郭子义陈建强关莹
Owner 海南省妇幼保健院