(R)-TAPP-BINOL-COF polymer as well as preparation method and application thereof

A TAPP-BINOL-COF and -BINOL-CHO technology is applied in the direction of organic chemical methods, chemical instruments and methods, organic compounds/hydrides/coordination complex catalysts, etc., which can solve the problem of poor chiral selectivity and low yield. High production cost of clopidogrel and increase of wastes, etc., to achieve the effect of easy separation, low price, high yield and stereoselectivity
CN110790925AActive Publication Date: 2020-02-14SHANDONG NORMAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANDONG NORMAL UNIV
Publication Date
2020-02-14

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Abstract

The invention belongs to the technical field of COF catalysts, and particularly relates to a (R)-TAPP-BINOL-COF polymer as well as a preparation method and applications thereof. The invention providesa preparation method and applications of covalent organic framework (R)-TAPP-BINOL-COF. The (R)-TAPP-BINOL-COF is crystallized in a C2 space group. The catalyst can effectively catalyze a synthetic reaction of a clopidogrel intermediate through photothermal conversion under illumination conditions, is mild in reaction conditions, short in reaction time and less in catalyst dosage, can be repeatedly used for more than five times, and has good economic significance when being applied to industrial production.
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Description

technical field

[0001] The disclosure belongs to the technical field of COF catalysts, and in particular relates to a two-dimensional chiral (R)-TAPP-BINOL-COF polymer, its preparation method, and its application as a chiral drug clopidogrel precursor catalyst. Background technique

[0002] The information disclosed in this Background section is only intended to increase the understanding of the general background of the disclosure, and is not necessarily to be taken as an acknowledgment or any form of suggestion that the information constitutes prior art that is already known to those skilled in the art.

[0003] Covalent organic frameworks (COFs) are a class of crystalline porous materials, which consist of organic building units connected by covalent bonds into an ordered structure, forming a periodic porous COFs framework. COFs have the advantages of large specific surface area, light weight, and stable structure, and have good development prospects in the fields of cata...

Claims

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