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A supramolecular polymer hydrogel with injectability and rapid recovery performance, its preparation method and application

A supramolecular polymer and rapid recovery technology, applied in drug delivery, pharmaceutical formulations, prostheses, etc., can solve the problems that limit the wide application of vitreous surgery, unsatisfactory, and prone to emulsification

Active Publication Date: 2021-09-07
TIANJIN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, silicone oil is widely used clinically as a filling material after vitrectomy, but it is not ideal as a vitreous replacement material
Silicone oil is prone to emulsification, cataract and other eye problems after long-term storage in the eye, which limits the wide application of vitreous surgery to a certain extent

Method used

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  • A supramolecular polymer hydrogel with injectability and rapid recovery performance, its preparation method and application
  • A supramolecular polymer hydrogel with injectability and rapid recovery performance, its preparation method and application
  • A supramolecular polymer hydrogel with injectability and rapid recovery performance, its preparation method and application

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Embodiment Construction

[0021] The technical solutions of the present invention will be further described below in conjunction with specific embodiments.

[0022] In the embodiment, poly(acryloyl glycinamide-co-acrylamide carboxylate betaine) (PNAGA-PCBAA) hydrogels with different monomer concentrations were synthesized, and PNAGA-PCBAA-10-4 (acryloyl glycinamide Aminoamide monomer and acrylamidocarboxybetaine monomer and initiator account for 10% of the total mass ratio of the two monomers, initiator and water, and acryloyl glycinamide monomer and acrylamidocarboxybetaine The mass ratio of alkali monomer is 4:1) as an example. After completely dissolving acryloyl glycinamide (NAGA) (104 mg) in 1224 μL of deionized water, add acrylamidocarboxybetaine (26 mg) and photoinitiator Irgacure 1173 (2-hydroxy-2-methyl-1- phenyl-1-propanone) 6 μL. After the mixed solution is filled with nitrogen to remove oxygen, the mixed solution is injected into a closed mold, and the mold is irradiated in a UV curing bo...

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Abstract

The invention discloses a supramolecular polymer hydrogel with injectability and fast recovery performance and its preparation method and application. It uses acryloyl glycinamide and acrylamidocarboxybetaine as raw materials, and in the presence of an initiator The poly(acryloyl glycinamide-copolymerization-acrylamidocarboxybetaine) supramolecular polymer hydrogel was prepared by free radical polymerization. The hydrogel of the present invention adjusts its mechanical properties by changing the initial monomer concentration, so that it can be injected at room temperature and recover quickly. At the same time, it can realize the function of self-repair at a lower temperature, and the gel has good Biocompatibility, the preparation method of the monomer and the hydrogel are simple and feasible, and the hydrogel of the present invention is expected to be used as a vitreous substitute.

Description

technical field [0001] The present invention relates to a kind of hydrogel and preparation method, relate to a kind of PNAGA-PCBAA hydrogel prepared by using acryloyl glycinamide (NAGA) and acrylamidocarboxybetaine (CBAA) as monomers The preparation method and performance research of the gel, the hydrogel has multiple functions such as rapid recovery, self-healing, anti-inflammation and anti-fibrosis, and is expected to be used as a vitreous replacement material. Background technique [0002] The vitreous body is a colorless and transparent jelly that fills the space between the lens and the retina. It is mainly composed of hyaluronic acid and collagen fibers. Most of the components are water. It has the functions of refraction and fixation of the retina, and has no regeneration ability. , With the increase of age, when the tissues around the vitreous body become lesions, the vitreous body will also be affected and undergo liquefaction, degeneration and turbidity. At presen...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/60C08F2/48A61L27/16A61L27/50A61L27/52
CPCA61L27/16A61L27/50A61L27/52A61L2400/06A61L2430/16C08F2/48C08F220/60C08L33/26
Inventor 刘文广王宏博
Owner TIANJIN UNIV
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