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Efficient low-toxic nuisanceless bactericidal agricultural new compound and composition thereof

A compound and composition technology, applied in the field of pesticides, can solve the problems of crop injury, high toxicity, and outstanding effect, and achieve the effects of reducing manufacturing costs and costs, facilitating storage and transportation, and reducing operating costs

Pending Publication Date: 2020-03-06
刘力
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Second, the effect is outstanding
[0015] 2. Most of the original drug products do not control or control the impurity content strictly
The high content of impurities in technical products may lead to adverse effects in many aspects. For example, some impurities have high toxicity, some will bring difficulties to the preparation processing, and some will reduce the stability of active ingredients.
With the use of preparation products, these impurities may also affect the environment and ecological safety, and even cause large-scale crop phytotoxicity.
[0017] So far, there are no published literature reports at home and abroad on the novel thiazole zinc compound of the present invention with better stability, such as thiazole zinc V-type crystal compound, that is, new thiazole zinc crystalline hydrates with different molecular formulas or different crystal forms and their preparation method and use

Method used

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  • Efficient low-toxic nuisanceless bactericidal agricultural new compound and composition thereof
  • Efficient low-toxic nuisanceless bactericidal agricultural new compound and composition thereof
  • Efficient low-toxic nuisanceless bactericidal agricultural new compound and composition thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0181] The preparation of embodiment 1 zinc thiazole 0.25 hydrate

[0182] At room temperature, add 7.991g of 2-amino-5-mercapto-1,3,4-thiadiazole to a 250ml flask, add 50ml of water, stir, add 20ml of an aqueous solution of 2.5g of sodium hydroxide, stir, and then add seven 30ml of an aqueous solution of 8.628g of zinc sulfate in water, stir at about 40°C for 20 minutes, place at room temperature for 15 minutes, filter with suction, wash the solid with a small amount of water until the filtrate has no sulfate ions, filter with suction, dilute the obtained solid at about 60°C and blow dry for about 4 hours , to obtain off-white solid 8.6g; HPLC: the main peak retention time of HPLC is consistent with the main peak retention time of the HPLC of thiazole zinc anhydrate; Karl Fischer's method measures moisture to be 1.33%, thermal analysis: platform weight loss is about 1.41% (see attachment figure 1 ), has corresponding endothermic peak (DTA) under the weight loss platform before...

Embodiment 2

[0183] The preparation of embodiment 2 thiazole zinc 0.25 hydrate (v type crystal compound)

[0184] Add 7.991g of 2-amino-5-mercapto-1,3,4-thiadiazole to a 500ml flask, add 40ml of water, stir, add dropwise an aqueous solution of 2.56g of sodium hydroxide (dissolved in 20ml of water), and stir for 30 minutes , then add 30ml of an aqueous solution of 8.628g of zinc sulfate heptahydrate, stir at about 35°C for 20 minutes, place at room temperature for half an hour, filter with suction, wash the solid filtrate with a small amount of water without sulfate ions, filter with suction, and dilute the obtained solid at about 45°C. Air-dried for 1 hour, and then dried at about 50°C for about 5 hours to obtain 8.5 g of off-white solid; HPLC: the retention time of the main peak of HPLC was consistent with that of zinc thiazole anhydrous; Thermal analysis: the weight loss of the platform is about 1.30% (see attached image 3 ), has a corresponding endothermic peak (DTA) under the weight ...

Embodiment 3

[0185] The preparation of embodiment 3 thiazole zinc 0.25 hydrate

[0186] At room temperature, add 8.0g of 2-amino-5-mercapto-1,3,4-thiadiazole to a 250ml flask, add 50ml of water, stir, add 30ml of an aqueous solution of 2.6g of potassium hydroxide, stir, then add chlorine 30ml of an aqueous solution of 4.09g of zinc chloride, stirred at about 40°C for half an hour, left at room temperature for half an hour, filtered with suction, washed the solid with a small amount of water, filtered with suction, diluted the obtained solid with air at about 50°C for about 4 hours, and obtained an off-white solid 8.6 g; HPLC: The retention time of the main peak of HPLC is consistent with the retention time of the main peak of HPLC of thiazole zinc anhydrate; the water content measured by the Karl Fischer method is 1.31%, thermal analysis: the weight loss of the platform is about 1.39%, and there is The corresponding endothermic peak (DTA), which contains 0.25 crystal water results (theoret...

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Abstract

An efficient low-toxic nuisanceless bactericidal agricultural new compound of the invention is a thiazole zinc nu-type compound. The energy consumption in preparation is lower, and the compound is easier to prepare, is more green and environment-friendly, has lower hygroscopicity, better storage stability or prevention and treatment effects, and the like, and is suitable for application in the preparation of a composition containing the compound, a pesticide used to prevent and treat various bacterial and fungal diseases on crops and to promote health or growth and development of the crops, or a medicament used in fields such as protecting industrial materials from germ invasion.

Description

technical field [0001] The invention relates to the technical field of pesticides, in particular to provide a high-efficiency, low-toxicity and pollution-free bactericidal drug thiazole zinc, a novel compound with better stability, a pesticide composition thereof, a preparation method and an application thereof. Background technique [0002] Zinc thiazole, the chemical name is bis(2-amino-5-mercapto-1,3,4-thiadiazole) zinc, CAS: 1202750-31-9, molecular formula, C 4 h 4 N 6 S 4 Zn, with a molecular weight of 329.77, can be used in the fine chemical industry, including photosensitive or material science, and is also an organozinc broad-spectrum fungicide developed by Zhejiang Xinnong Chemical Co., Ltd. The drug has multiple functions such as systemic absorption, conduction, prevention, protection, and treatment, and its therapeutic effect is greater than its protective effect. Both bacterial and fungal diseases have good control effect. 20% Zinc Thiazole Suspension Concen...

Claims

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Application Information

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IPC IPC(8): C07D285/135A01N43/824A01N43/54A01N37/50A01N43/78A01N47/24A01N43/653A01P21/00A01P3/00A01P1/00
CPCC07D285/135A01N43/82A01N43/54A01N37/50A01N43/78A01N47/24A01N43/653C07B2200/13
Inventor 刘力
Owner 刘力
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