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Preparation method and application of macrophage membrane bionic bismuth selenide nanoparticles

A technology of bismuth triselenide and bismuth trioxide, which is applied in the field of medicine, can solve problems such as no public reports, and achieve the effect of enhancing anti-tumor effect, increasing retention and accumulation, and simple and feasible preparation process

Inactive Publication Date: 2020-03-13
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, it is of great significance and value to invent a drug delivery system of cell membrane biomimetic bismuth triselenide nanoparticles in cancer treatment, but there has been no public report so far

Method used

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  • Preparation method and application of macrophage membrane bionic bismuth selenide nanoparticles
  • Preparation method and application of macrophage membrane bionic bismuth selenide nanoparticles
  • Preparation method and application of macrophage membrane bionic bismuth selenide nanoparticles

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Embodiment 1

[0025] A method for preparing macrophage membrane bionic bismuth selenide nanoparticles of the present invention comprises the following steps:

[0026] 1), bismuth trioxide nanoparticles (Bi 2 o 3 Synthesis of NPs): Dissolve 0.36g of bismuth nitrate pentahydrate in 10mL of 1mol / L nitric acid solution, add 0.1g of sodium hydroxide, 1.2g of polyvinylpyrrolidone, and 50mL of ethylene glycol under stirring and mix evenly, transfer to high temperature React, heat up to 150°C at a rate of 5°C per minute, maintain a constant temperature for 3h, then cool to room temperature, wash 5 times with 500mL deionized water each time, and dry to obtain bismuth trioxide nanoparticles (Bi 2 o 3 NPs);

[0027] 2), hollow mesoporous bismuth triselenide nanoparticles (Bi 2 Se 3Synthesis of NPs (abbreviated as BS NPs): Dissolve 0.2 g of sodium selenite and 0.6 g of D-(+)-glucose in 50 mL of deionized water, and add the bismuth trioxide nanoparticles ( Bi 2 o 3 NPs) aqueous solution, tran...

Embodiment 2

[0032] A method for preparing macrophage membrane bionic bismuth selenide fluorescent nanoparticles comprises the following steps:

[0033] 1), bismuth trioxide nanoparticles (Bi 2 o 3 Synthesis of NPs): Dissolve 0.36g of bismuth nitrate pentahydrate in 10mL of 1mol / L nitric acid solution, add 0.1g of sodium hydroxide, 1.2g of polyvinylpyrrolidone, and 50mL of ethylene glycol under stirring and mix evenly, transfer to high temperature React, heat up to 150°C at a rate of 5°C per minute, maintain a constant temperature for 3h, then cool to room temperature, wash 5 times with 500mL deionized water each time, and dry to obtain bismuth trioxide nanoparticles (Bi 2 o 3 NPs);

[0034] 2), hollow mesoporous bismuth triselenide nanoparticles (Bi 2 Se 3 Synthesis of NPs (abbreviated as BS NPs): Dissolve 0.2 g of sodium selenite and 0.6 g of D-(+)-glucose in 50 mL of deionized water, and add the bismuth trioxide nanoparticles ( Bi 2 o 3 NPs) aqueous solution, transferred to ...

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Abstract

The invention relates to a preparation method and application of macrophage membrane bionic bismuth selenide nanoparticles. The preparation problem of macrophage membrane bionic bismuth selenide nanoparticles and the application problem in preparing bionic anti-tumor drugs and photothermal treatment drugs based on cell membrane wrapping can be effectively solved. According to the technical scheme,the surface of hollow bismuth selenide nanoparticles is physically loaded with an anti-tumor drug quercetin, and then the hollow bismuth selenide nanoparticles with the quercetin is co-extruded withcell membrane vesicles obtained by low-permeability lysis solution pyrolysis treatment of cells and homogenization, so as to obtain a pharmaceutical composition of the cell membrane bionic bismuth selenide nanoparticles with a particle size of 120-150nm. The preparation process is simple and feasible; the particle size distribution is uniform; the sensitivity of cancer cell to light and heat is enhanced, and the anti-tumor effect of photothermal therapy is enhanced; the macrophage membrane bionic bismuth selenide nanoparticles have multiple functions such as metastatic lesions targeting capability, CT imaging and the like; and the anti-tumor efficacy of the drug is improved.

Description

technical field [0001] The invention relates to medicine, in particular to a preparation method and application of macrophage membrane bionic bismuth selenide nanoparticles. Background technique [0002] Photothermal therapy (PTT), as an effective cancer treatment option, has been developed due to its hyperthermic role in cancer treatment and its key role in improving the therapeutic efficiency of other treatment options such as chemotherapy and photodynamic therapy. become quite attractive. Especially, imaging-guided PTT, which can simultaneously monitor and kill tumors in one nanosystem, has attracted extensive research attention in the scientific community due to its convenience, selectivity, remote control, and high efficiency. In recent years, bismuth-based nanoparticles have been used not only as X-ray computed tomography contrast agents but also as sensitizers to enhance PTT for cancer treatment. Hollow mesoporous bismuth selenide nanoparticles (Bi 2 Se 3 NPs) ha...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K9/50A61K47/46A61K49/04A61P35/00
CPCA61K41/0052A61K9/5063A61K49/04A61P35/00
Inventor 王蕾赵洪娟张振中赵倍倍吴丽遐
Owner ZHENGZHOU UNIV
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