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High-biological-activity poly(ether-ether-ketone) composite artificial joint prosthesis and preparation method thereof

A technology of polyether ether ketone and composite materials, which is applied in the direction of prosthesis, tissue regeneration, and other household appliances. It can solve the problems of poor biological activity and achieve rapid response, high productivity, and long service life.

Pending Publication Date: 2020-03-17
CHANGZHOU WASTON MEDICAL APPLIANCE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to address the deficiency of poor medical bioactivity of polyetheretherketone in the prior art, and to provide a polyether ether ketone with high bioactivity and a preparation method thereof, which uses 4,4`-bis[2-(1 -propenyl)phenoxy]benzophenone and 3-(mercaptomethyl)benzoic acid are used as raw materials, and a dicarboxyl-terminated etherketone structure is obtained through addition reaction, which can be combined with hydroxyapatite and polyether After the blending and extrusion of ether ketone, a highly bioactive polyetheretherketone composite material is obtained, and an artificial prosthesis of a highly bioactive polyetheretherketone composite material is obtained by injection molding, which improves the bioactivity of polyetheretherketone and provides polyetheretherketone Fastness with hydroxyapatite, while ensuring sufficient strength and good biocompatibility of the material, has high clinical use value and broad market prospects

Method used

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  • High-biological-activity poly(ether-ether-ketone) composite artificial joint prosthesis and preparation method thereof
  • High-biological-activity poly(ether-ether-ketone) composite artificial joint prosthesis and preparation method thereof
  • High-biological-activity poly(ether-ether-ketone) composite artificial joint prosthesis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Step (1) Dissolve 1mol 4,4'-bis[2-(1-propenyl)phenoxy]benzophenone and 1.2mol 3-(mercaptomethyl)benzoic acid in 30mol N,N-dimethyl in methyl formamide, stirred evenly, placed under UV lamp, and irradiated for 5 minutes to obtain dicarboxyl-terminated ether ketone structure (IR: 1591cm -1 : -C=C- exists in the benzene ring; 1246cm -1 、1168cm -1 :-C-O-C-Existence; 1699cm -1 :-C=O exists; 3547cm -1 : -OH exists; 1655cm -1 :-C=C-disappears), denoted as A.

[0032] Step (2) Disperse 100 parts by weight of hydroxyapatite raw material with a particle size of 5 μm in 1000 ml of N,N-dimethylformamide, ultrasonically disperse for 2 hours, add 150 parts by weight of A, and heat and stir at 120°C for reaction , after the reaction is complete, A modified hydroxyapatite (IR: 1591cm -1 : -C=C- exists in the benzene ring; 1246cm -1 、1168cm -1 :-C-O-C-Existence; 1699cm -1 :-C=O exists; 3547cm -1 : -OH exists; 1100cm -1 、1030cm -1 :-O-P-O-exists).

[0033] Step (3) Put 50 pa...

specific Embodiment 2-6

[0034] Specific embodiment 2-6, other are with specific embodiment 1, difference is following table:

[0035]

[0036]

[0037] The polyether ether ketone composite pellets obtained in specific example 1 were used as the basic material of the application example, and made into artificial prosthesis of high biological activity polyether ether ketone composite material.

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Abstract

The invention belongs to the field of novel materials, and relates to a high-biological-activity poly(ether-ether-ketone) composite artificial joint prosthesis and a preparation method thereof. 4,4'-bis[2-(1-propenyl)phenoxy]benzophenone and 3-(mercaptomethyl)benzoic acid are adopted as raw materials and subjected to an addition reaction to obtain a dicarboxyl-terminated ether ketone structured substance; the obtained substance is blended and extruded with hydroxyapatite and poly(ether-ether-ketone) to obtain a high-biological-activity poly(ether-ether-ketone) composite; and the high-biological-activity PEEK composite is subjected to injection molding to obtain the high-biological-activity poly(ether-ether-ketone) composite artificial joint prosthesis. The biological activity of PEEK is improved, firmness between the poly(ether-ether-ketone) and the hydroxyapatite is provided, that the material has sufficient strength and good biocompatibility is ensured, and the artificial joint prosthesis has a high clinical application value and broad market prospects.

Description

technical field [0001] The invention relates to a highly biologically active polyether ether ketone composite material artificial prosthesis and a preparation method thereof. The invention belongs to the field of new materials. Background technique [0002] Bone plays an important role in supporting, hematopoiesis, and maintaining blood calcium balance in the human body. Bone damage will seriously affect human health and the quality of life of patients. According to statistics, there are tens of millions of patients with bone defects or bone injuries caused by various traffic, production accidents, orthopedic diseases and other factors in my country every year, and about 2 million patients need joint replacement surgery. Bone injury seriously affects the quality of life of patients and has become a serious social problem. [0003] At present, the artificial bone replacement materials used are still mainly metals: stainless steel and cobalt-based alloys are used as biomedic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L61/16C08K9/04C08K3/32C08G8/02A61L27/46A61L27/50B29B7/00B29B9/06B29C45/77B29C45/78B29C48/92
CPCC08K9/04C08K3/32C08G8/02A61L27/46A61L27/50B29C48/92B29B9/06B29C45/78B29C45/77B29B7/002A61L2430/02B29C2948/92704B29C2948/9259B29C2948/92885B29C2945/76531B29C2945/76498B29C2945/76859B29L2031/7532C08K2003/325C08L61/16
Inventor 高崇勇王逸杰
Owner CHANGZHOU WASTON MEDICAL APPLIANCE CO LTD