Preparation method of tulathromycin

A technology of tebramycin and compound, which is applied in the field of preparation of tebramycin and can solve problems such as difficulty in operation
CN110903335AInactive Publication Date: 2020-03-24SUNSHINE LAKE PHARM CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SUNSHINE LAKE PHARM CO LTD
Publication Date
2020-03-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a preparation method of tulathromycin, and belongs to the field of pharmaceutical chemicals. The method comprises the following steps of: reacting azithromycin serving as a rawmaterial with phenyl chloroformate to protect hydroxyl to obtain protected nitrogen azithromycin, oxidizing the hydroxyl into a ketone group by oxidation, epoxidizing, deprotecting, and reacting withn-propylamine to obtain tulathromycin. The product produced by the method has the characteristics of high purity, high yield, low cost, simple operation and stable process.
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Description

technical field

[0001] The invention relates to the field of medicine and chemical industry, in particular to a preparation method of telamycin. Background technique

[0002] Tulathromycin (Tulathromycin), also known as tulamycin, tolamycin. The drug is a new type of erythromycin semi-synthetic veterinary antibiotic developed by Pfizer Animal Health in the late 1990s. From 1998 to 2003, Pfizer registered patent protection for its compound, synthetic process and preparation. On October 13, 2004, the EU Veterinary Medical Advisory Committee (VMAC) approved Tyramycin Injection Draxxin to be launched in the EU; on May 24, 2005, the U.S. Food and Drug Administration (FDA) approved Tyramycin Injection Ricksin is launched in the United States. The Ministry of Agriculture of my country approved the domestic use of telamycin for the first time in Announcement No. 957 in 2008. And from the Groton production plant of Pfizer of the United States and the Ambiose production plant of P...

Claims

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