Surface molecular imprinting SERS (Surface Enhanced Raman Scattering) sensor based on core-shell structure polydopamine coated gold nanoparticles as well as preparation and application of surface molecular imprinting SERS sensor

A technology of surface molecular imprinting and gold nanoparticles, which is applied in the fields of nanotechnology for sensing, nanotechnology for materials and surface science, nanotechnology, etc. Reduced sensitivity, difficult to control the thickness of molecularly imprinted membrane, etc., to achieve the effects of mild preparation conditions, increased content, and mild reaction conditions

Active Publication Date: 2020-03-24
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the preparation of molecularly imprinted polymers (MIP) usually requires the addition of cross-linking agents and initiators to initiate the polymerization of functional monomers. The preparation steps are complicated, and the thickness of the molecularly imprinted polymer is difficult to control, resulting in a decrease in the sensitivity of the SERS sensor.
In addition, molecularly imprinted SERS sensors still have the problem of mutual interference of spectral peaks in complex samples, so how to draw the target analyte to the region where the surface plasmon resonance is enhanced is very important

Method used

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  • Surface molecular imprinting SERS (Surface Enhanced Raman Scattering) sensor based on core-shell structure polydopamine coated gold nanoparticles as well as preparation and application of surface molecular imprinting SERS sensor
  • Surface molecular imprinting SERS (Surface Enhanced Raman Scattering) sensor based on core-shell structure polydopamine coated gold nanoparticles as well as preparation and application of surface molecular imprinting SERS sensor
  • Surface molecular imprinting SERS (Surface Enhanced Raman Scattering) sensor based on core-shell structure polydopamine coated gold nanoparticles as well as preparation and application of surface molecular imprinting SERS sensor

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Experimental program
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Embodiment 1

[0046] This embodiment relates to the preparation of a molecularly imprinted SERS sensor with core-shell structure polydopamine encapsulated gold nanoparticles. For details, see figure 1 , Including the following steps:

[0047] 1) Synthesis of AuNPs: accurately add 1.2ml of 1×10 into a clean 50ml small beaker -2 mol·L -1 Tetrachloroauric acid solution (HAuCl 4 ), add ultrapure water to 50mL, and boil; add 0.5mL of 8g / L sodium citrate dropwise, boil for 30 minutes to obtain a gold glue solution with a particle size of about 25nm, cool to room temperature and store in a refrigerator at 4°C for use ; figure 2 The medium-dark line is the UV absorption peak of AuNPs, the wavelength is 530nm, according to image 3 The electron micrograph in, shows that the UV absorption peak of AuNPs around 25nm is 530nm;

[0048] 2) Preparation of AuNPs@PDA-MIP core-shell structure material: Weigh DA and dissolve it in Tris-HCl buffer to obtain a Tris-HCl buffer solution (pH=8.5) with a DA concentratio...

Embodiment 2

[0051] In this embodiment, in step 2), the concentration of dopamine is 2 mg / mL, and the rest is the same as in embodiment 1.

Embodiment 3

[0053] In this embodiment, in step 2), the concentration of dopamine is 3 mg / mL, and the rest is the same as in embodiment 1.

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Abstract

The invention relates to a surface molecular imprinting SERS (Surface Enhanced Raman Scattering) sensor based on core-shell structure polydopamine coated gold nanoparticles as well as preparation andapplication of the surface molecular imprinting SERS sensor. A preparation method comprises the following steps: by taking dopamine as a functional monomer and a phthalate substance as a template molecule, carrying out self-polymerization on the surfaces of gold nanoparticles to obtain a molecularly imprinted polymer, eluting the molecularly imprinted polymer, and dropwise coating the surface of ascreen-printed electrode with the molecularly imprinted polymer to obtain the surface molecularly imprinted SERS sensor. Compared with the prior art, the invention is combined with a Raman spectrometer, by combining electrochemical enrichment and molecular imprinting technologies, high-selectivity and high-sensitivity detection of phthalate substances in a water body in a complex environment canbe realized at the same time, and the sensor has the advantages of simple preparation process, high detection speed, no need of sample pretreatment, environmental friendliness, low cost and the like,and shows a wide application prospect.

Description

Technical field [0001] The invention belongs to the technical field of nano-material preparation and surface-enhanced Raman spectroscopy detection, and relates to a surface molecularly imprinted SERS sensor based on core-shell structure polydopamine-coated nano-gold particles, and preparation and application thereof. Background technique [0002] With the large-scale use of plastics and other industrial products, it is easy to cause improper behavior in the process of production, transportation, use, and even disposal, and leak into the environmental water body, seriously polluting the water environment. The research and development of a new type of portable high-throughput sensor that can rapidly and sensitively detect a variety of endocrine disruptors and corresponding new separation and enrichment technologies can provide strong technical support for the risk assessment and emergency treatment of water pollution accidents. One of the urgent requirements for safety, ensuring na...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65B82Y30/00B82Y40/00B82Y15/00
CPCG01N21/658B82Y30/00B82Y40/00B82Y15/00Y02A20/20
Inventor 李原婷杨圆圆李冰冰李学剑韩生蔺华林胡晓敏薛原
Owner SHANGHAI INST OF TECH
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