Preparation method of nano magnetic particles

A nano-magnetic particle and magnetic particle technology, which is applied in the preparation of microspheres and microcapsule preparations, can solve the problems of uneven size, large surface area, and small particle size of magnetic microspheres, and achieve easy control of the size and preparation Simple method and uniform particle size

Inactive Publication Date: 2020-03-27
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AI-Extracted Technical Summary

Problems solved by technology

[0003] At present, the production method of magnetic microspheres seen in the market is a one-step method, also known as co-precipitation method, which refers to the preparation method of producing magnetic polymer microspheres while generating magnetic substances, that is, adding Fe 2+ and H 2 o 2 Formula FeCl 2 , FeCl 3 Stir to form an alkali, which is used to increase the PH value, so that once the magnetic substance is produced, it will be wrapped to form a core-shell magnetic polymer microsphere, and the magnetic microspheres produced have a small particle size and a large surface area. less responsive
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The invention provides a preparation method of nano magnetic particles, which comprises the following steps: firstly, adsorbing a hydrophobic substance on magnetic particles to form hydrophobic strongmagnetic particles; secondly, carrying out emulsification for the first time, namely, adding a surfactant, a monomer solvent and an initiator into the hydrophobic strong magnetic particles to enablethe surfactant to be adsorbed on the surfaces of the hydrophobic strong magnetic particles, and performing ultrasonic treatment to form magnetic particles with uniform in-core particle size; and finally, carrying out emulsification for the second time, namely, continuing to add the initiator and water, heating to 90-110 DEG C, performing reaction for 2-24h, and performing ultrasonic treatment to form magnetic particles with uniform outer diameter of the polymer.

Application Domain

Microballoon preparationMicrocapsule preparation

Technology Topic

ChemistryActive agent +4


  • Preparation method of nano magnetic particles


  • Experimental program(1)

Example Embodiment

[0024] See figure 1 , Is the process flow chart of the present invention, as shown in the figure, the method includes the following steps:
[0025] Step 1: Adsorb the hydrophobic substance on the magnetic particles to form hydrophobic strong magnetic particles;
[0026] Step 2: Perform the first emulsification, add surfactant, monomer solvent and initiator to the hydrophobic strong magnetic particles;
[0027] Step 3: The surfactant is adsorbed on the surface of the hydrophobic strong magnetic particles;
[0028] Step 4: Ultrasonic ultrasonic treatment;
[0029] Step 5: Form magnetic particles with uniform particle size in the core;
[0030] Step 6: Perform the second emulsification, add initiator and water, and heat to 90-110 。 C, the reaction time is 2-24h;
[0031] Step 7: Ultrasonic ultrasonic treatment and cleaning;
[0032] Step 8: Form magnetic particles with a uniform outer diameter of the polymer.
[0033] In this embodiment, the magnetic particles are one of ferric chloride, ferrous chloride, and iron oxide.
[0034] In this embodiment, the hydrophobic substance is an alkaline aqueous solution added with a strong adsorption substance.
[0035] In this embodiment, the strong adsorbent is one of fatty acid, fat, hydrophilic carboxyl group, and phosphorous group.
[0036] In this embodiment, the surfactant is a nonionic surfactant.
[0037] In this embodiment, the monomer solvent is one of a radical polymerization reaction monomer, styrene, acrylic acid, vinyl chloride, and acrylate.
[0038] In this embodiment, the initiator is one of potassium persulfate, ammonium persulfate, azobisisobutyronitrile, and azo polyethylene glycol.
[0039] The following is a specific embodiment of the method for preparing nano magnetic particles of the present invention:
[0040] 40nm magnetic particles are resolved in the aqueous solution, and the 200mg suspension is added with an aqueous sodium hydroxide solution of undecylenic acid. Undecylenic acid is adsorbed on the ferromagnetic particles to form hydrophobic magnetic particles. The hydrophobic ferromagnetic particles add non-ionic surface activity Agent, tirtonX-45 0.4g, treated with ultrasonic, non-ionic surfactant is adsorbed on the surface of hydrophobic particles to form a colloidal liquid. Add 0.1ml of the ionic surfactant n-undecylamine to the colloidal liquid to form a re-water There are non-ionic surfactants on the surface of gelatinous substances, and ionic activities coexist. In the polymerization reaction, styrene 3.0g, GMA 0.3g, AIBN 0.03g, DVB0.09g, and ethyl ether 2.5g were mixed into the gum to form a latex. Aging reaction, 70 degrees in KPS50mg, superposition reaction for 10 hours, washing three times to obtain iron oxide-coated polymer, through endoscopic observation, the average particle size is 163nm, the standard deviation is within 20nm, there are 1-4 titanium oxide in the core particle.


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