Preparation method of nano magnetic particles

Abstract

The invention provides a preparation method of nano magnetic particles, which comprises the following steps: firstly, adsorbing a hydrophobic substance on magnetic particles to form hydrophobic strongmagnetic particles; secondly, carrying out emulsification for the first time, namely, adding a surfactant, a monomer solvent and an initiator into the hydrophobic strong magnetic particles to enablethe surfactant to be adsorbed on the surfaces of the hydrophobic strong magnetic particles, and performing ultrasonic treatment to form magnetic particles with uniform in-core particle size; and finally, carrying out emulsification for the second time, namely, continuing to add the initiator and water, heating to 90-110 DEG C, performing reaction for 2-24h, and performing ultrasonic treatment to form magnetic particles with uniform outer diameter of the polymer.

Description

technical field [0001] The invention relates to the field of chemical synthesis, in particular to a preparation method of nanometer magnetic particles. Background technique [0002] Nanomagnetic microspheres have attracted much attention in molecular biology, medical diagnosis and treatment, bioengineering and environmental pollutant removal. In particular, nano-magnetic microspheres are used in the diagnosis, extraction, drug delivery, and hyperthermia treatment of DNA, proteins, and virus cells; after nucleic acid immobilization, magnetism is used for SNP detection and mRNA analysis; antibody-immobilized magnetic bodies are used for trace antigen determination, etc. new method. Targeted therapy of target cells isolated from pathogens (such as cancer cell isolation) and evaluation of the effect of the treatment process have great application value. It has become one of the extremely important analytical tools in the fields of life sciences, exploration of the mysteries of...

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Problems solved by technology

[0003] At present, the production method of magnetic microspheres seen in the market is a one-step method, also known as co-precipitation method, which refers to the preparation method of producing magnetic polymer microspheres while generating magnetic substances, that is, adding Fe 2+ and H 2 o 2 Formula FeCl 2 , FeCl 3 Stir to form an alkali, which is used to increase the PH value, so that once the magnetic substance is produced, it will be wrapped to form a core-shell magnetic polymer microsphere, and the magnetic microspheres produced have a small particle size and a large surface area. less responsive

[0004] The two-step method is also a commonly used method, which refers to the preparation of Fe 3 o 4 Microparticles, and then mix them with polymer monomers to obtain magnetic polymer microspheres, which have low room temperature conductivity and magnetic susceptibility, and difficult to control the structure and performance

[0005] The preparation of magnetic polymer microspheres by the interface deposition method is determined by the size of the initial polymer particles. The particle size is easy to control, the size is uniform, and the magnetic consistency is strong, but it is not resistant to organic solvents.

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