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Sustained-release sodium butyrate suitable for aquatic animals and preparation method of sustained-release sodium butyrate

A slow-release sodium butyrate and aquatic animal technology, which is applied in the molding or processing of animal feed, animal feed, application, etc., can solve the problems of short enzymatic digestion time, high content of unsaturated fatty acids, and incompatibility with the intestinal tract of aquatic animals, etc. problem, to achieve the effect of improving the utilization rate and shortening the enzymatic digestion time

Pending Publication Date: 2020-04-10
湖南普菲克生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

2. The polyunsaturated fatty acid (PUFA) content in the intestinal tract of aquatic animals is high, which is easily damaged by oxidation
3. Aquatic animals are temperature-changing animals, the digestive tract is always connected with the external environment, and there is no stable internal environment
These factors will affect the coating material, thereby affecting the dissolution effect of butyric acid and reducing the utilization rate of the intestinal tract of aquatic animals
[0009] At present, many coated sodium butyrate products are not designed for sustained release according to the physiological digestion and living environment characteristics of aquatic animals. The release point, time and dissolution effect of butyric acid are designed based on the characteristics of digestion such as short digestion time, most of them have no stomach, and can only eat in water, and the living environment temperature is low.

Method used

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  • Sustained-release sodium butyrate suitable for aquatic animals and preparation method of sustained-release sodium butyrate
  • Sustained-release sodium butyrate suitable for aquatic animals and preparation method of sustained-release sodium butyrate
  • Sustained-release sodium butyrate suitable for aquatic animals and preparation method of sustained-release sodium butyrate

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preparation example Construction

[0039] see figure 1 , a preparation method of slow-release sodium butyrate suitable for aquatic animals, comprising the following steps:

[0040] Preparation of water-soluble matrix sustained-release granules: First, mix sodium butyrate and hydrophilic gel matrix materials evenly to make preliminary granules, then mix and dissolve the film-forming materials and spray on the surface of the prepared granules to form a coating layer to obtain water-soluble Matrix slow-release granules;

[0041] Preparation of fat-soluble sustained-release granules: melt and mix the blocking agent and sodium butyrate, then perform cold-spray granulation to obtain fat-soluble sustained-release granules;

[0042] Mixing: Mix the water-soluble matrix sustained-release granules prepared above with the fat-soluble sustained-release granules evenly to obtain the sustained-release sodium butyrate suitable for aquatic animals.

Embodiment 1

[0044] A preparation method of slow-release sodium butyrate applicable to aquatic animals, the specific steps are as follows:

[0045] 1) In parts by weight, take the raw materials according to the following formula, and set aside:

[0046] Sodium butyrate: 30 parts

[0047] HPMC: 1 part

[0048] Sodium alginate: 15 parts

[0049] J-stearate: 35 parts

[0050] Acrylic resin No. Ⅳ: 10 parts

[0051] Polyethylene glycol: 4 parts

[0052] Talc powder: 5 parts

[0053] 2) Granulation: Mix 15 parts of sodium butyrate with hydrophilic gel skeleton material: 1 part of HPMC, 15 parts of sodium alginate, add 10-25 parts of water to prepare a soft material, and extrude in a granulator Made into soft strips and rounded into 300-500 micron preparatory particles in a spherical shot blasting machine. Then dry the prepared granules in a fluidized dryer with an inlet air temperature of 105-110°C for 30-50 minutes to ensure that the material is dry while reducing energy consumption.

...

Embodiment 2

[0058] A preparation method of slow-release sodium butyrate applicable to aquatic animals, the specific steps are as follows:

[0059] 1) In parts by weight, take the raw materials according to the following formula and set aside.

[0060] Sodium butyrate: 50 parts

[0061] HPMC: 1 part

[0062] Gelatin: 10 parts

[0063] J-stearate: 25 parts

[0064] Acrylic resin No. Ⅳ: 7 parts

[0065] Polyethylene glycol: 4 parts

[0066] Talc powder: 3 parts

[0067] 2) Granulation: mix 25 parts of sodium butyrate with hydrophilic gel skeleton material: 1 part of HPMC, 9 parts of gelatin, add 10-25 parts of water to prepare a soft material, and extrude it in a granulator Soft strips are rounded into 300-500 micron preparatory particles in a spherical shot blasting machine. Then dry the prepared granules in a fluidized dryer with an inlet air temperature of 105-110°C for 30-50 minutes to ensure that the material is dry while reducing energy consumption.

[0068] 3) Coating: Mix 7 p...

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Abstract

The invention provides a preparation method of sustained-release sodium butyrate suitable for aquatic animals. The preparation method includes the following steps: firstly, uniformly mixing sodium butyrate and a hydrophilic gel framework material to prepare preliminary particles, mixing and dissolving a film-forming material, and spraying the film-forming material to the surfaces of the preliminary particles to form a coating layer to obtain water-soluble framework sustained-release particles; secondly, performing melt mixing on a retardant and sodium butyrate, and performing cold spray granulation to obtain fat-soluble sustained-release particles; and finally, uniformly mixing the water-soluble framework sustained-release particles and fat-soluble sustained-release particles to obtain thesustained-release sodium butyrate suitable for the aquatic animals. The product is prepared according to the characteristics of digestion physiology, living environment and feeding characteristics ofthe aquatic animals, the product adopts the combined technology of the water-soluble framework sustained-release particles and fat-soluble sustained-release particles to control the release site, release time and release amount of the sodium butyrate in intestines of the aquatic animals, and the utilization rate of the sodium butyrate in the intestines of the aquatic animals is greatly improved.

Description

technical field [0001] The invention relates to the technical field of feed additives for aquatic animals, in particular to a slow-release sodium butyrate suitable for aquatic animals and a preparation method thereof. Background technique [0002] The growth of aquatic animals is closely related to the health of the intestinal tract. Intestinal health is an important guarantee for the health of the body, and it is the main place for aquatic animals (especially fish without stomach) to digest and absorb nutrients. At the same time, the intestinal tract is also the largest mucosal immune organ and the most fragile immune barrier of aquatic animals. The performance is as follows: 1. The intestinal wall structure of aquatic animals is thin, only 1 / 20 of the thickness of mammals. For example, the thickness of piglet jejunum intestinal wall is 2271 μm, The intestinal wall thickness of tilapia is only 92 μm, so the intestinal tract of aquatic animals is extremely vulnerable to dama...

Claims

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Application Information

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IPC IPC(8): A23K20/10A23K20/105A23K40/10A23K40/30A23K50/80
CPCA23K20/10A23K20/105A23K40/10A23K40/30A23K50/80Y02A40/818
Inventor 常翠维柏美娟刘亚力彭地纬罗国升潘长咏黄兴国戴富全
Owner 湖南普菲克生物科技有限公司
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