Organic nonmetal catalyst for preparing poly(p-dioxanone)

Abstract

The invention discloses an organic nonmetal catalyst for preparing poly(p-dioxanone), wherein dioxanone is subjected to a ring-opening polymerization reaction under the action of an organic non-metalcatalyst and an initiator carrying a hydroxyl structure to obtain the poly(p-dioxanone), and the structural formula of the organic non-metal catalyst is selected from one or more of the following formulas described in the specification, wherein R1 and R2 groups are respectively and independently aliphatic groups or cyclic groups. According to the organic nonmetal catalyst provided by the invention, efficient ring-opening polymerization of monomers is realized by activating functional groups in PDO, and the polymerization reaction has the advantages of high activity, easiness in adjustment andmild reaction.

Description

technical field [0001] The invention belongs to the technical field of organic catalytic systems, and in particular relates to an organic non-metallic catalyst for preparing polydioxanone. Background technique [0002] Since the last century, aliphatic polyesters have been used as biomedical and environmentally friendly materials due to their good biocompatibility, absorbability and biodegradability. Polydioxanone (PPDO), as a typical aliphatic polyester, is similar to polycaprolactone (PCL), polylactic acid (PLA), and polyglycolic acid (PGA). The ester bond in the molecular chain Endow it with good biocompatibility, biodegradability and absorbability; the unique ether bond in the PPDO molecular chain endows it with excellent flexibility and tensile strength, and natural polymer materials (such as: chitin, Compared with chitosan, gelatin, etc.), it makes up for the defects that their mechanical properties are reduced due to the influence of pore structure, so that PPDO stan...

AI Technical Summary

Problems solved by technology

Wang Yuzhong's team and others use AlEt 3 -H 2 O-H 3 PO 4 The catalytic system realizes the efficient ring-opening polymerization of PDO under the reaction condition of 80 degrees Celsius, and the molecular weight is as high as more than 100,000. However, the metal-based catalytic system generally has the defects of long reaction time, low conversion rate, and difficult to control side reactions.

Although the above-mentioned catalytic system realizes the ring-opening polymerization of PDO, most of the catalytic systems used are metal catalysts, which lack modulation factors, resulting in fewer control factors for the activity of PDO ring-opening polymerization. Prolonging the time can be adjusted, but increasing the temperature and prolonging the time tends to increase the side reactions, resulting in a wider distribution of polymeric materials and product decomposition, which is very unfavorable for subsequent material processing.

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