A kind of self-restoring porous composite gel and its preparation method and application
A composite gel and self-recovery technology, applied in the field of gel, can solve the problems that hydrogel does not have a porous structure, cannot realize material self-degradation, and is not conducive to tissue cell growth, and achieves controllable air and moisture permeability, good biophase Capacitive, wide range of effects
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[0041] The invention provides a method for preparing a self-recovering porous composite gel, the preparation process of which is as follows: figure 1 shown, including the following steps:
[0042] S1. Dissolve chitosan in deionized water, adjust its pH to 2-4 with acid solution, filter and remove impurities after chitosan is completely dissolved, and obtain a chitosan solution with a predetermined concentration; heat and dissolve agar in deionized water Prepare an agar solution with a predetermined concentration in water; then mix the chitosan solution and the agar solution evenly according to a preset volume ratio, and after cooling and forming, a composite gel is obtained;
[0043] S2. Place the composite gel prepared in step S1 in a mold, and place the mold above the liquid nitrogen level, keep the mold at a preset distance from the liquid nitrogen level, based on the liquid The gradient low temperature environment caused by nitrogen induces the directional growth of water...
Embodiment 1
[0052] see figure 1 , this embodiment provides a method for preparing a self-recovering porous composite gel, comprising the following steps:
[0053] S1, add 4g chitosan to 96mL deionized water, utilize 1% HCl to adjust the pH of the solution to 3, after the chitosan is completely dissolved, filter the insoluble impurities to obtain a chitosan solution with a concentration of 4% ; Add 2 g of agar into 98 mL of deionized water, stir magnetically and heat to 90° C. for 5 minutes to completely dissolve it, and obtain an agar solution with a concentration of 2%. The chitosan solution and the agar solution were mixed at a volume ratio of 1:1 at 37° C., and after being stirred evenly, the mixed solution was poured into a watch glass and naturally cooled to room temperature to obtain a composite gel. The composite gel is in the form of a thin film.
[0054] S2. Place the composite gel prepared in step S1 in a copper mold, place the mold at 2 cm above the liquid nitrogen level, and...
Embodiment 2
[0061] This example provides a method for preparing a self-recovering porous composite gel. Compared with Example 1, the difference is that in step S1, the mixed solution formed by chitosan solution and agar solution is poured into 24 wells In the plate, after naturally cooling to room temperature, a columnar composite gel was obtained. The other steps were the same as in Example 1, and will not be repeated here.
[0062] Such as Figure 4 As shown, the shape self-restoring porous composite gel prepared in this embodiment is cylindrical, and the cylindrical shape self-restoring porous composite gel is subjected to acid-base and heating and cooling cycles, and its state changes are as follows: Figure 5 shown. Wherein, the shape self-restoring porous composite gel prepared in this example is a double network structure formed by interpenetrating chitosan reversible physical network and agar reversible physical network.
[0063] When subjected to acid-base cycle treatment, chit...
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