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Method for production of fish peptide with immobilized compound protease

A compound protease and protease technology, applied in the field of proteolysis, can solve the problems of low enzymatic hydrolysis efficiency and complicated enzymatic hydrolysis steps, and achieve the effects of simple preparation process, reduced production cost, and improved thermal stability

Active Publication Date: 2020-04-10
广东希普生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The method uses two immobilized enzymes to carry out two-step enzymatic hydrolysis of squid minced meat, the enzymatic hydrolysis steps are relatively complicated, and the enzymatic hydrolysis efficiency is low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The method for producing fish peptides by using immobilized composite protease in this embodiment includes the following steps:

[0027] 1) Take 0.5 kg of gelatin and 2 kg of sodium alginate and dissolve them in 100 kg of water at a temperature of 60°C to obtain a carrier solution.

[0028] 2) Add the protease mixture to the carrier solution in step 1). The protease mixture is a mixture of alkaline protease and trypsin. The mass ratio of alkaline protease, trypsin and carrier solution is 4:2:100, stir to dissolve , To obtain a composite protease solution.

[0029] 3) Drop the composite protease solution in step 2) onto CaCl 2 Immobilized in the solution into particles with a particle size of 0.5~2.5mm, CaCl 2 CaCl in solution 2 The mass ratio to water is 1.5:100, constant stirring during the immobilization process, the immobilization time is 30min, and the curing temperature is 25℃. After the immobilization is completed, filter with a 40-mesh sieve to obtain immobilized compos...

Embodiment 2

[0032] The method for producing fish peptides by using immobilized composite protease in this embodiment includes the following steps:

[0033] 1) Take 0.5 kg of gelatin and 2 kg of sodium alginate and dissolve them in 100 kg of water at a temperature of 60°C to obtain a carrier solution.

[0034] 2) Add the protease mixture to the carrier solution in step 1). The protease mixture is a mixture of alkaline protease and trypsin. The mass ratio of alkaline protease, trypsin and carrier solution is 4:2:100, stir to dissolve , To obtain a composite protease solution.

[0035] 3) Drop the composite protease solution in step 2) onto CaCl 2 Immobilized in the solution into particles with a particle size of 2~2.5mm, CaCl 2 CaCl in solution 2 The mass ratio to water is 2:100. Stir constantly during the immobilization process. The immobilization time is 50min and the immobilization temperature is 28℃. After the immobilization is completed, the immobilized composite enzyme particles are obtained...

Embodiment 3

[0038] The method for producing fish peptides by using immobilized composite protease in this embodiment includes the following steps:

[0039] 1) Take 1 kg of gelatin and 2 kg of sodium alginate and dissolve them in 100 kg of water at a temperature of 60° C. to obtain a carrier solution.

[0040] 2) Add the protease mixture to the carrier solution in step 1). The protease mixture is a mixture of alkaline protease and trypsin. The mass ratio of alkaline protease, trypsin and carrier solution is 6:4:100. Stir to dissolve , To obtain a composite protease solution.

[0041] 3) Drop the composite protease solution in step 2) onto CaCl 2 Immobilized in the solution into particles with a particle size of 0.5~1.5mm, CaCl 2 CaCl in solution 2 The mass ratio to water is 2.5:100. Stir constantly during the immobilization process. The immobilization time is 30min and the immobilization temperature is 22℃. After the immobilization is completed, filter with a 40-mesh sieve to obtain immobilized c...

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Abstract

The invention relates to a method for production of fish peptide with immobilized compound protease. The method includes the steps of: dissolving gelatin and sodium alginate in water to obtain a carrier solution, adding a protease mixed solution into the carrier solution, and conducting stirring dissolution to obtain a compound protease solution, adding the compound protease solution dropwise intoa CaCl2 solution for immobilization into particles, performing stirring continuously in the immobilization process, and then conducting filtering to obtain immobilized compound enzyme particles, mixing the immobilized compound enzyme particles obtained in step 3) with fish paste, conducting enzymolysis at 40-60DEG C for 2-10h and performing stirring, and then carrying out sieving to separate outthe immobilized compound enzyme particles. The method can improve the thermal stability of protease, also the immobilized compound enzyme particles can be recycled, and the production cost is reduced.In addition, the immobilized compound enzyme particles are used for one-time enzymolysis of the fish paste, and the enzymolysis efficiency is high.

Description

Technical field [0001] The invention belongs to the technical field of proteolysis, and specifically relates to a method for producing fish peptides by using immobilized composite proteases. Background technique [0002] Fish has a high protein content, a complete variety of essential amino acids, and has a good composition ratio and balanced characteristics. Fish peptide is not only an important nitrogen source, but also has a series of physiological functions in the body, such as lowering blood cholesterol, reducing body fat, and enhancing immunity. [0003] There are many methods for preparing fish peptides, the main method is enzymatic hydrolysis. Fish proteolysis is the enzymatic hydrolysis of fish protein into fish peptides under the action of various proteases. However, the enzyme has shortcomings such as easy denaturation, inability to withstand high temperatures, and difficulty in recycling, so the enzyme can be cured before enzymolysis. For example, the invention paten...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N11/14C12N11/10C12N11/02C12P21/06
CPCC12N11/02C12N11/10C12N11/14C12P21/06
Inventor 劳泰财余忠丽恽辉王俊青程林春
Owner 广东希普生物科技股份有限公司