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Device and method for controlling follicular development and preventing reproductive tract inflammation of equine animals

A follicle development and reproductive tract technology, applied in drug delivery, drug combination, pharmaceutical formulations, etc., can solve animal disease treatment and human health threats, drug-resistant bacteria, reduce the use of antibiotics, etc., to achieve auxiliary fixation of embolus, Less stress response and larger contact area

Active Publication Date: 2021-06-08
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Traditional antibiotic treatment can easily lead to the emergence of drug-resistant bacteria in animals, which will pose a serious threat to animal disease treatment and human health. The country has required that the use of antibiotics be gradually reduced in animal production

Method used

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  • Device and method for controlling follicular development and preventing reproductive tract inflammation of equine animals
  • Device and method for controlling follicular development and preventing reproductive tract inflammation of equine animals
  • Device and method for controlling follicular development and preventing reproductive tract inflammation of equine animals

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Embodiment one: female donkey is in estrus at the same time

[0060] In the National Donkey Breeding Center in Dong'e County, Shandong Province, 19 Dezhou black female donkeys aged 7-8 years old with normal fertility were selected and injected on the 0th day from April 15, 2018 to May 1, 2018 GnRH (1ml), on the 2nd day, the device of the present invention was put into the female donkey's vagina (CRID), and on the 8th day, prostaglandin (PG) 4ml was injected, and on the 11th day, the device of the present invention was taken out and injected with PGF4ml. From the 12th day to the 16th day, B-ultrasound examination was carried out every day to observe the follicular development of the female donkey and whether the device of the present invention could inhibit ovulation. When the B-ultrasound examination found that the follicle was greater than 32mm, it could be considered as estrus. Project process such as image 3 , the estrus results of female donkeys after implementati...

Embodiment 2

[0063] Embodiment two: female donkey estrus synchronously and artificial insemination

[0064] In the Dong’e Black Donkey Breeding Base in Aohan Banner, Inner Mongolia, 80 Dezhou black female donkeys with normal fertility and aged 7-8 were selected and injected with GnRH (1ml) on the 0th day from May to August 2018 On the 2nd day, insert the device of the present invention into the vagina of the donkey, inject 4ml of PG on the 8th day, take out the device of the present invention and inject 4ml of PG on the 11th day, and the donkey will perform B-ultrasound every day from the 12th to the 16th day Check to observe the follicle development of the donkey and whether the device of the present invention can inhibit ovulation. When the B-ultrasound examination finds that the follicle is greater than 32mm, it can be considered as estrus. After 12 hours, artificial insemination was carried out with fresh semen, the volume of each insemination was 10ml, and the total effective sperm co...

Embodiment 3

[0067] Embodiment 3: Simultaneous estrus and artificial insemination of female donkeys

[0068] At Zhangjiakou Sangyang Animal Husbandry Co., Ltd. in Hebei Province, 76 Dezhou black female donkeys with normal fertility and aged 4-8 years were selected and divided into two batches from July to August 2019. GnRH (1ml) was injected on the 0th day, the device of the present invention was inserted into the donkey's vagina on the 2nd day, PG 4ml was injected on the 8th day, the device of the present invention was taken out on the 11th day and PG 4ml was injected, and the donkey arrived on the 12th day. On the 16th day, B-ultrasound examination was carried out every day to observe the follicle development of the female donkey and whether the device of the present invention could inhibit ovulation. When the B-ultrasound examination found that the follicle was greater than 32mm, it could be considered as estrus. After 12 hours, artificial insemination was carried out with fresh semen, ...

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Abstract

The invention provides a device and a method for controlling follicle development of equine animals and preventing and treating reproductive tract inflammation. The device is composed of a nylon bracket and a slow-release device. The slow-release device is fixedly installed on the nylon bracket. The nylon bracket includes: a connecting part and two long arms, and the two long arms are connected to the connecting part respectively, and the two long arms are connected to the connecting part respectively. A certain angle is formed between two long arms, and the long arm is composed of a cylinder and a top sphere, the top of the cylinder is provided with a top sphere, and the bottom of the cylinder is connected with the connecting part, and the slow release device includes two circles Each cylinder is provided with a number of small holes and disc structures arranged in an orderly manner. The small holes are set between the two disc structures. The top of the cylinder is a hollow round cap. The cylinder is covered with a long On the arm, the hollow round cap matches the top sphere, so that the cylinder is fixed on the long arm, and the disc structure is perpendicular to the extension direction of the long arm.

Description

technical field [0001] The invention belongs to the animal breeding field of animal husbandry and veterinary medicine, and aims to provide a vaginal implant device for controlling estrus of large animals and preventing and treating reproductive tract inflammation and a preparation method thereof. Background technique [0002] The total number of large livestock such as donkeys, horses, dairy cows, beef cattle, buffaloes, yaks, red deer and camels in my country is more than 100 million (horses). With the adjustment of industrial structure and the improvement of environmental protection requirements, intensive and large-scale breeding of fine breeds has gradually become the mainstream. Correspondingly, the demand for reproductive control technology and obstetric disease prevention and control has increased rapidly. For example, the simultaneous estrus and timed artificial insemination technology of cows, mares and female donkeys can reduce the group empty time, shorten the ca...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61D7/00A61K9/02A61K45/06A61K47/04A61P15/00A61P15/08
CPCA61D7/00A61K9/0034A61K9/02A61K45/06A61K47/02A61P15/00A61P15/08
Inventor 曾申明李楠杨峰
Owner CHINA AGRI UNIV
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