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Mouthwash effervescent granules, preparation method and use method thereof

An effervescent granule, pharmacologically active technology, applied in anti-inflammatory agents, oral care, pharmaceutical formulations, etc., can solve the problems of inconvenient portability of bottled mouthwash, limited protection of oral health, destruction of medicinal active ingredients, etc. For oral cleaning, enhanced granulation effect, fast-acting effect

Inactive Publication Date: 2020-04-14
ZHEJIANG HUAKANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing mouthwashes have the following disadvantages: 1. bottled mouthwashes are inconvenient to carry
② Mouthwash water is divided into health mouthwash and medicinal mouthwash. Health mouthwash can only play a role in refreshing breath, and medicinal mouthwash is mostly chemical substances with bactericidal effects and cannot be used for a long time
③Most mouthwashes on the market taste bad, and the price is too high for ordinary consumers, which limits the ability of Chinese people to protect oral health
Plant compound formulas often use high-temperature cooking and evaporation to concentrate to extract medicinal active ingredients, so that the medicinal active ingredients are destroyed and the content is low, and the effect is not good
And often only water extraction or alcohol extraction is used, so that part of the active ingredient is wasted
⑤Most solid granules need to be dissolved before taking, which reduces the convenience of use
⑥In effervescent preparations, mixed powders are often used for direct acid-base embedding, which is not conducive to maintaining the activity of acid- or alkali-unstable components

Method used

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Examples

Experimental program
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Effect test

preparation example Construction

[0029] The present invention also discloses a preparation method of the mouthwash effervescent granule as described above, comprising the following steps:

[0030] Step 1. Extracting pharmacologically active ingredients from dandelion root, honeysuckle, coix seed, wrinkled ageratum, centella asiatica, mugwort leaf and tangerine peel to obtain water-soluble pharmacologically active dry powder and alcohol-soluble pharmacologically active dry powder respectively.

[0031] Step 2, using the water-soluble pharmacologically active dry powder obtained in Step 1 to prepare pharmacologically acidic granules.

[0032] Step 3, using the alcohol-soluble pharmacologically active dry powder obtained in step 1 to prepare pharmacologically basic granules.

[0033] Step 4: Mix the pharmacologically acidic granules obtained in step 2 with the pharmacologically basic granules obtained in step 3 at a ratio of 1:1 to obtain the finished mouthwash effervescent granules.

Embodiment 1

[0036] The embodiment of the preparation method of the first mouthwash effervescent granule of the present invention, comprises the steps:

[0037] Step 11, 15-20% by weight of dandelion root, 15-20% of honeysuckle, 10-20% of coix seed, 5-10% of Huoxiang, 5-10% of Artemisia argyi, 5-10% of Centella asiatica, 10~20% tangerine peel 500g powdered in total, the powder was fried at 80°C for 5 minutes, mixed with warm water at 50°C at a ratio of 1:20, and homogenized.

[0038] Step 12: Add 0.5-1% cellulase and mix evenly, react in a water bath with constant temperature and micro-magnetic stirring at 50-60°C for 1 hour to dissolve a large amount of biologically active substances, and centrifuge at 5000rpm for 15 minutes.

[0039] Step 13: The supernatant obtained by centrifuging in step 12 is subjected to 0.22 μm ultrafiltration, and then concentrated through 1000 Da, 500 Da and 150 Da three-stage nanofiltration membrane filtration, and all the filtrates are collected and freeze-drie...

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PUM

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Abstract

The invention relates to mouthwash effervescent granules, wherein the components of the formula comprise the following components: dandelion roots, honeysuckle, coix seeds, agastache rugosus, centellaasiatica, folium artemisiae argyi, citrus chachiensis hortorum, cellulase, citric acid, sodium bicarbonate, maltitol, xylitol, mannitol, ethanol, polyethylene glycol 6000 and psicose. The invention also discloses a preparation method and a use method of the mouthwash effervescent granules. The mouthwash effervescent granules have the characteristics of long-term use, good cleaning and antibacterial effects, convenience in use and carrying and the like.

Description

technical field [0001] The invention belongs to the technical field of preparation of mouthwash granules, in particular to an effervescent mouthwash granule and its preparation method and usage method. Background technique [0002] Mouthwash is one of the hottest oral cleaning products. The existing mouthwash has the following disadvantages: 1. bottled mouthwash is inconvenient to carry. ② Mouthwash water is divided into health mouthwash and medicinal mouthwash. Health mouthwash can only play a role in freshening breath, while medicinal mouthwash is mostly chemical substances with bactericidal effects and cannot be used for a long time. ③Most of the mouthwashes on the market taste bad, and the price is too high for ordinary consumers, which limits the ability of Chinese people to protect their oral health. ④Plant compound formulas often use high-temperature cooking and evaporation to concentrate to extract medicinal active ingredients, so that the medicinal active ingredie...

Claims

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Application Information

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IPC IPC(8): A61K8/02A61K8/9789A61K8/9794A61K8/66A61K8/34A61K8/60A61Q11/00A61P29/00
CPCA61K8/0283A61K8/9789A61K8/9794A61K8/66A61K8/345A61K8/602A61Q11/00A61P29/00A61K2800/805
Inventor 柳艳云陈倩毛宝兴汪秀秀吴爱娟魏子尧龚小平
Owner ZHEJIANG HUAKANG PHARMA
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