Mouthwash effervescent granules, preparation method and use method thereof
An effervescent granule, pharmacologically active technology, applied in anti-inflammatory agents, oral care, pharmaceutical formulations, etc., can solve the problems of inconvenient portability of bottled mouthwash, limited protection of oral health, destruction of medicinal active ingredients, etc. For oral cleaning, enhanced granulation effect, fast-acting effect
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[0029] The present invention also discloses a preparation method of the mouthwash effervescent granule as described above, comprising the following steps:
[0030] Step 1. Extracting pharmacologically active ingredients from dandelion root, honeysuckle, coix seed, wrinkled ageratum, centella asiatica, mugwort leaf and tangerine peel to obtain water-soluble pharmacologically active dry powder and alcohol-soluble pharmacologically active dry powder respectively.
[0031] Step 2, using the water-soluble pharmacologically active dry powder obtained in Step 1 to prepare pharmacologically acidic granules.
[0032] Step 3, using the alcohol-soluble pharmacologically active dry powder obtained in step 1 to prepare pharmacologically basic granules.
[0033] Step 4: Mix the pharmacologically acidic granules obtained in step 2 with the pharmacologically basic granules obtained in step 3 at a ratio of 1:1 to obtain the finished mouthwash effervescent granules.
Embodiment 1
[0036] The embodiment of the preparation method of the first mouthwash effervescent granule of the present invention, comprises the steps:
[0037] Step 11, 15-20% by weight of dandelion root, 15-20% of honeysuckle, 10-20% of coix seed, 5-10% of Huoxiang, 5-10% of Artemisia argyi, 5-10% of Centella asiatica, 10~20% tangerine peel 500g powdered in total, the powder was fried at 80°C for 5 minutes, mixed with warm water at 50°C at a ratio of 1:20, and homogenized.
[0038] Step 12: Add 0.5-1% cellulase and mix evenly, react in a water bath with constant temperature and micro-magnetic stirring at 50-60°C for 1 hour to dissolve a large amount of biologically active substances, and centrifuge at 5000rpm for 15 minutes.
[0039] Step 13: The supernatant obtained by centrifuging in step 12 is subjected to 0.22 μm ultrafiltration, and then concentrated through 1000 Da, 500 Da and 150 Da three-stage nanofiltration membrane filtration, and all the filtrates are collected and freeze-drie...
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