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Degradable ureteral stent and manufacturing method thereof

A ureteral stent tube and a manufacturing method technology are applied in the field of degradable ureteral stent tube and its manufacture, can solve the problems of loss or even need to remove the kidney, bleeding and tissue damage, poor tissue compatibility, etc., and achieve good mechanical support performance, degradation The effect of prolonging the speed and improving the mechanical properties

Active Publication Date: 2021-12-14
SECOND AFFILIATED HOSPITAL OF XIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The main components of the currently used ureteral stents are non-absorbable polyurethane, silicone rubber and metal materials, which need to be removed by surgery again after surgery, and have poor tissue compatibility, which is easy to form stones, infection, bleeding and tissue damage
If the stent is placed for a long time, it will cause serious consequences, such as the loss of renal function and even the need to remove the kidney
And a second surgery is required to remove the indwelling stent

Method used

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  • Degradable ureteral stent and manufacturing method thereof

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Effect test

Embodiment 1

[0036] Such as figure 1 As shown, the degradable ureteral stent in the present invention is composed of polycaprolactone adventitia layer 1, polyglycolide fiber and polyglycolide-lactide fiber braiding layer 2, L-lactide-ε- Caprolactone copolymer / graphene inner film layer 3 composition.

[0037] The graphene layer of the inner membrane layer 3 is single-layer graphene with a thickness of 0.3 nm, and the thickness of each L-lactide-ε-caprolactone copolymer layer is 0.1 μm.

[0038] The preparation method of the inner film layer 3 comprises: (1) the L-lactide-ε-caprolactone copolymer solution is attached to the graphene / copper sheet with the graphene side by spin coating method or casting method, and air-dried 10h; then etch the copper sheet in ammonium persulfate solution, etch at room temperature for 8h to obtain L-lactide-ε-caprolactone copolymer / graphene film; (2) L-lactide-ε -Transfer the caprolactone copolymer / graphene film to the surface of the graphene / copper sheet, ma...

Embodiment 2

[0047] The degradable ureteral stent tube in the present invention is composed of polylactic acid outer membrane layer 1, polydioxanone fiber and polytrimethylene carbonate fiber braided layer 2, L-lactide-ε-caprolactone copolymer / The graphene inner film layer 3 is composed.

[0048] The graphene layer of the inner membrane layer 3 is single-layer graphene with a thickness of 0.4 nm, and the thickness of each L-lactide-ε-caprolactone copolymer layer is 1 μm.

[0049] The preparation method of the inner film layer 3 comprises: (1) the L-lactide-ε-caprolactone copolymer solution is attached to the graphene / copper sheet with the graphene side by spin coating method or casting method, and air-dried 10h; then etch the copper sheet in ammonium persulfate solution, etch at room temperature for 8h to obtain L-lactide-ε-caprolactone copolymer / graphene film; (2) L-lactide-ε -Transfer the caprolactone copolymer / graphene film to the surface of the graphene / copper sheet, make the side of...

Embodiment 3

[0058] The degradable ureteral stent tube in the present invention is composed of polyglycolide outer membrane layer 1, polyhydroxyalkanoate fiber and polylactic acid-glycolic acid copolymer fiber braiding layer 2, L-lactide-ε-caprolactone Copolymer / graphene inner film layer 3 composition.

[0059] The graphene layer of the inner membrane layer 3 is single-layer graphene with a thickness of 0.35 nm, and the thickness of each L-lactide-ε-caprolactone copolymer layer is 2 μm.

[0060] The preparation method of the inner film layer 3 comprises: (1) the L-lactide-ε-caprolactone copolymer solution is attached to the graphene / copper sheet with the graphene side by spin coating method or casting method, and air-dried 10h; then etch the copper sheet in ammonium persulfate solution, etch at room temperature for 8h to obtain L-lactide-ε-caprolactone copolymer / graphene film; (2) L-lactide-ε -Transfer the caprolactone copolymer / graphene film to the surface of the graphene / copper sheet, m...

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Abstract

The invention discloses a degradable ureteral stent and a manufacturing method thereof, and relates to the technical field of medical catheters. In order to solve the technical problem in the prior art that the ureteral stent cannot be absorbed by the human body and requires surgical removal, the technical solution of the present invention is as follows : The degradable ureteral stent in the present invention comprises an adventitia layer made of degradable material, a braided layer and an intima layer, and the braided layer is braided by two different degradable materials. The ureteral stent tube of the present invention is composed of intima layer, braided layer and adventitia layer of different degradable materials, and utilizes the difference in thermal properties and degradation speed of multi-component degradable materials to improve the overall mechanical properties of the stent tube and improve the degradation rate. further extended.

Description

technical field [0001] The invention relates to the technical field of medical catheters, in particular to a degradable ureteral stent and a manufacturing method thereof. Background technique [0002] Ureteral stents are widely used in urological operations such as upper urinary tract obstructive lesions, nephroureteral calculus, urinary system trauma, and upper urinary tract reconstruction. The main function of a ureteral stent is to keep the ureter open and drain urine into the bladder. [0003] The main components of the currently used ureteral stents are non-absorbable polyurethane, silicone rubber, and metal materials, which need to be taken out again after surgery, have poor tissue compatibility, and are prone to stone formation, infection, bleeding, and tissue damage. If the stent tube is placed for a long time, it will cause serious consequences, such as loss of renal function or even nephrectomy. And a second operation is required to remove the indwelling stent. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L29/12A61L29/02A61L29/06A61L29/14
CPCA61L29/06A61L29/02A61L29/148A61L29/14C08L67/04
Inventor 倪锋惠鹏宇白艳郑亮
Owner SECOND AFFILIATED HOSPITAL OF XIAN MEDICAL UNIV