Preparation method of temperature-sensitive microgel uniformly coated with nano iron oxide
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A nano-iron oxide, temperature-sensitive technology, applied in the field of preparation of temperature-sensitive microgels, can solve problems such as inconvenience
Inactive Publication Date: 2020-04-14
WEIFANG UNIV OF SCI & TECH
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Problems solved by technology
[0005] However, the use of temperature-sensitive nano- or micro-gels for encapsulating nanoparticles, especially magnetic iron oxide nanoparticles with targeting effects, has not been reported yet.
[0006]
In summary, there are obviously inconveniences and defects in the actual use of the existing technology, so it is necessary to improve
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[0034] The invention provides a method for preparing a temperature-sensitive microgel uniformly coated with nanometer iron oxide, comprising the following steps:
[0035] step one
[0036] A determines the amount of added deionized water in the reaction process;
[0037] B According to the amount of deionized water added, three kinds of methoxyethyl acrylate (MEA), oligo(ethylene glycol) methyl ether acrylate (PEGA) and acetoacetate methacrylate (AAEM) were respectively determined. The amount of monomer added;
[0038] C Determine the magnetic iron oxide nanoparticles (γ-Fe 2 o 3 ), polyethylene glycol diacrylate (PEGDA), polyvinylpyrrolidone (PVP) and potassium persulfate (KPS) added (relative to monomer mass).
[0039] In the present invention, three monomers and magnetic iron oxide nanoparticles (γ-Fe2 o 3 ), polyethylene glycol diacrylate (PEGDA), polyvinylpyrrolidone (PVP) and potassium persulfate (KPS), all replaced by chemical formula or English letter abbreviation...
Embodiment 1
[0061] In a 20mL reaction bottle, accurately measure 4.7mL deionized water, and then add accurately weighed 139.3mgMEA, 96.3mg PEGA, 14.3mg AAEM, 7.5mg PEGDA, 50mg PVP, 178.6μL γ-Fe 2 o 3 (1.4 mg / mL). After sealing the reaction bottle, pass nitrogen gas to remove oxygen for 30 minutes, then inject 100 μL of the aqueous solution containing 1.88 mg potassium persulfate previously deoxygenated into the above sealed reaction bottle with a micro syringe, and then quickly transfer it into the oil that has been preheated and the temperature is stable at 70 ° C. In the bath, the stirring speed was controlled to be 800r / min under nitrogen atmosphere, and the reaction was continued for 6h.
Embodiment 2
[0063] Whole reaction process is identical with embodiment 1, only gamma-Fe 2 o 3 The amount added was changed to 893 μL.
[0064] The TEM spectra of thermosensitive microgels at different magnifications are shown in figure 2 and image 3 .
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Abstract
The invention is applicable to the technical field of high polymer material manufacturing, and provides a preparation method of a temperature-sensitive microgel uniformly coated with nano iron oxide.The preparation method comprises the following steps: sequentially adding monomers MEA, PEGA and AAEM into a sealable container to obtain a mixed material I; adding gamma-Fe2O3, PEGDA, PVP and deionized water into the mixed material I, stirring, sealing the container, transferring the container into an ice-water bath, blowing nitrogen and discharging oxygen for 30-60 minutes to obtain a material II; injecting a KPS solution into the material II; and continuously introducing nitrogen, and reacting for 6 hours to obtain the temperature-sensitive microgel. According to the preparation method, thepreparation method is short in reaction time, high in preparation efficiency, strong in whole reaction controllability and high in repeatability, and the prepared temperature-sensitive microgel is uniform in particle size and can be applied to the fields of drug carriers, targeted therapy or sensors and the like.
Description
technical field [0001] The invention relates to the technical field of polymer material manufacturing, in particular to a method for preparing temperature-sensitive microgel uniformly coated with nanometer iron oxide. Background technique [0002] Nano-sized particles (usually 1-100nm in diameter) have unique physical, chemical and biological properties compared with their large-sized particles. These properties have important applications in industrial production, advanced materials in biotechnology and medicine. Nanoparticles currently realized mainly include silicon, carbon, transition metals, metal oxides, polymers, and the like. Among them, the most unique properties are surface-modified magnetic particles, which have important applications in molecular diagnosis and separation of proteins and cells. Compared with conventional separation methods such as centrifugation or filtration, magnetic separation has the advantages of high efficiency, simplicity, and small sample...
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