A kind of precise light regulation system and light regulation method

Abstract

The invention provides a precise light regulation system and light regulation method, including a laser speckle illumination subsystem, which provides laser speckle illumination light; a spatial light stimulation subsystem, which provides spatial stimulation light; an imaging acquisition subsystem, which receives laser speckle light Illumination light and spatial stimulation light are coupled, and the imaging field of view is provided for laser speckle imaging; the image processing subsystem includes: a feedback adjustment module, which outputs an adjustment signal to the space light according to the imaging result of the laser speckle The stimulation subsystem makes it output the adjusted spatial stimulation light; the visual field matching module performs spatial matching between the adjusted spatial stimulation light field and the imaging field of view before the next imaging. Real-time acquisition of imaging by the image processing subsystem and feedback to adjust the spatial stimulation light, the adjusted spatial stimulation light forms a new light stimulation, and a new biological image is obtained according to the light stimulation, and finally realizes the closed loop of real-time control of the spatial stimulation light Light regulation system.

Description

technical field [0001] The invention relates to the field of optical imaging, in particular to a precise light control system and a light control method. Background technique [0002] Optical regulation is a method of regulating the activity, state, and properties of matter by interacting with matter through the interaction of light field. Especially for biological tissues, light is one of the important means to regulate their physiological functional states. For example, the use of photochemical effects can form embolism of blood vessels. The cerebral ischemia method based on the principle of photochemistry can use the irradiation beam to select the area and location of the infarction, which has the advantages of simple operation and good repeatability. However, in the current photochemical ischemia, it is difficult to achieve flexible and precise irradiation beam regulation due to the lack of methods to dynamically modulate the temporal-spatial distribution of the irradi...

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Problems solved by technology

[0003] In particular, the traditional photochemical cerebral ischemia process lacks real-time evaluation of the vascular blockage caused by photochemical effects, so it is impossible to adjust the dose of irradiated light in real time, which often leads to early opening of the blood-brain barrier, and may cause serious microvascular damage, that is, the source of blood vessels. cerebral edema

Lack of real-time blood flow imaging feedback methods can also cause direct infarction and ischemia of brain tissue in the perivascular cortical area due to excessive light dose when a single small vessel is embolized

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