Traditional Chinese medicine composition for treating functional dyspepsia and preparation method thereof

A technology for indigestion and composition, which is applied in the direction of drug combination, digestive system, and pharmaceutical formula, which can solve problems such as unstable curative effect, inconvenience for patients, and no unified treatment plan, so as to increase voluntary activity, increase body weight, and promote gastric motility Improved effect

Inactive Publication Date: 2020-04-21
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional Chinese medicine uses syndrome differentiation and treatment, taking into account both symptoms and root causes, and often achieves satisfactory results in the diagnosis and treatment of functional dyspepsia. Prescribing based on the doctor's own

Method used

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  • Traditional Chinese medicine composition for treating functional dyspepsia and preparation method thereof
  • Traditional Chinese medicine composition for treating functional dyspepsia and preparation method thereof
  • Traditional Chinese medicine composition for treating functional dyspepsia and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0043] The present invention is used in an embodiment of a traditional Chinese medicine composition for treating functional dyspepsia. The traditional Chinese medicine composition is made of the following raw materials in parts by weight: Bupleurum 3g, Fructus Aurantii 2.5g, and Tangerine Peel 3g; It is prepared by frying with vinegar; the Fructus Fructus Fructus is prepared by frying bran; the preparation method of the Chinese medicine composition comprises the following steps:

[0044] 1) Weigh each component, add water 10 times its total weight, and soak for 30 minutes;

[0045] 2) Heat to boiling with strong fire, then change to slow fire and cook for 1 hour;

[0046] 3) Filter, then add water 5 times the total weight of the original components and continue to decoct for 40 minutes;

[0047] 4) Filtration; the two filtrates were combined and concentrated to 2.95 g / mL.

Embodiment 2

[0054] Example 2 Effect of Chenpi Fructus Aurantium Compatible with Bupleurum on FD (Functional Dyspepsia) Mice

[0055] SPF grade Kunming mice, weighing about 20g. The mice were randomly divided into normal group (control), model group (Model), experimental group (CCZ) and control group (CZ).

[0056]Adaptive feeding was carried out for one week before modeling, and water and feed were free to drink during this period. Among them, the model group, the experimental group and the control group used restraint, excessive fatigue swimming and electric shock as daily fixed stimuli, and combined with chronic unpredictable stress (triple-combined stress method) to establish the FD mouse model; the daily fixed stimuli Proceed as follows: Use a homemade restraint tube ( figure 1 ) after successfully restraining the mouse, shock the tail of the mouse for 5 minutes and keep restraining for 6 hours, then shock again for 5 minutes and release the restraint. As the standard of fatigue; t...

Embodiment 3

[0084] Example 3 Tangerine Peel and Fructus Aurantii Compatible with Bupleurum on 5-HT and 5-HT in FD Mice 4 R impact

[0085] Brain-gut peptides present in the central nervous system (CNS) and endogenous enteric nervous system (ENS) are important signaling molecules that regulate gastrointestinal motility. Among them, Substance P (Substance P) and 5-hydroxytryptamine (5-hydroxytryptamine, 5-HT), as an important class of monoamine neurotransmitters, widely exist in the CNS and ENS. In the central system, SP and 5-HT have physiological functions such as regulating mental emotions, participating in cognition, sleep, protecting neurons, and anti-depression, among which 5-HT is closely related to the pathogenesis of depression; in the gastrointestinal tract, SP is an excitatory neurotransmitter in the gastrointestinal tract, which can produce physiological effects of enhancing gastrointestinal motility; while 5-HT can produce various regulatory functions such as promoting gastric...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating functional dyspepsia and a preparation method thereof. The composition is prepared from the following raw materials: radix bupleuri, pericarpium citri reticulatae and fructus aurantii; wherein the weight ratio of radix bupleuri to pericarpium citri reticulatae to fructus aurantii is (5-7): (5-7): (4-6); radix bupleuriis used as a liver-soothing medicine; pericarpium citri reticulatae and the fructus aurantii are used for regulating qi; the effects of soothing the liver, regulating qi and harmonizing the liver andthe spleen are achieved; weight is increased effectively, appetite is increased, the mental state is improved (sucrose preference percentage is increased), the autonomous activity is increased, gastric residue is reduced, the content of motilin and the like is increased, the content of p substance, the expression of 5-HT and 5-HT4R can be further up-regulated, Ca<2+> internal flow of is increased,and the regulation effect of a 5-HT system on gastrointestinal tracts is enhanced, thereby promoting gastric motility improvement; therefore, the functional dyspepsia is treated from the root and symptoms, both symptoms and root causes are treated, and the traditional Chinese medicine composition has universality for various dialectical types of the functional dyspepsia.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating functional dyspepsia and a preparation method thereof. Background technique [0002] Functional dyspepsia is the most common functional gastrointestinal disease in clinical practice. It has symptoms such as upper abdominal pain, upper abdominal distension, early satiety, belching, loss of appetite, nausea, and vomiting. The organic causes of the above symptoms are excluded after examination. A group of clinical syndromes of disease. The etiology includes disturbance of gastric fundus relaxation after eating, disorder of gastric antrum duodenal movement coordination, and visceral hypersensitivity. In recent years, more and more clinical data have shown that psychological, environmental and social factors and other factors are functional dyspepsia. important incentives. Currently, there is no specific...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61P1/14
CPCA61K36/233A61K36/752A61K2236/331A61K2236/39A61P1/14A61K2300/00
Inventor 王术玲龚彦溶梁晓霞
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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