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Near-field microscopy system and construction method thereof

A near-field microscope and atomic force microscope technology, applied in the field of designing biomedical testing, can solve the problems of fast transient behavior characterization of difficult-to-be-measured objects, inability to use near-field terahertz imaging technology, etc., to enhance repeatability and reliability. to avoid the effect of severe signal attenuation

Inactive Publication Date: 2020-04-21
SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
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Problems solved by technology

[0006] In view of the shortcomings of the prior art described above, the purpose of the present invention is to provide a near-field microscope system and its construction method, which are used to solve the problem that the prior art cannot be used in the near-field terahertz imaging technology, and it is difficult to quickly detect the object under test. Problems such as characterizing transient behavior

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  • Near-field microscopy system and construction method thereof
  • Near-field microscopy system and construction method thereof

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Embodiment 1

[0100] Such as figure 1 As shown, the present invention provides an infrared / terahertz near-field microscopy system based on an atomic force microscope. The infrared / terahertz near-field microscopy system based on an atomic force microscope includes: a terahertz quantum cascade laser, an infrared laser, a sample Cavity, CCD image sensor, terahertz near-field spectral imaging system, infrared near-field spectral imaging system and computer. Its main structure is as figure 2 As shown, it includes: a laser 1 , an optical path coupling module 2 and an atomic force microscope 3 .

[0101] Such as figure 2 As shown, the laser 1 is used to provide laser light as a light source.

[0102] Specifically, in this embodiment, the laser 1 includes a terahertz quantum cascade laser 11 and an infrared laser 12, the terahertz quantum cascade laser 11 and the infrared laser 12 have the same or symmetrical optical paths, and the infrared laser The spectrum range is 800-2000cm -1 .

[010...

Embodiment 2

[0135] This embodiment provides a terahertz medical imaging detector based on an infrared / terahertz near-field microscopy system of an atomic force microscope. First, a terahertz medical imaging detector based on atomic force is fabricated by using the above method, and then the imaging detector is used to realize real-time functional imaging of human brain tissue. The human brain is the most complex and important part of the human body. Safe, accurate and rapid real-time imaging of human brain tissue will provide an extremely valuable inspection method for modern medicine, which is of great significance to human health.

[0136] The working principle of the terahertz medical imaging detector based on atomic force is as follows: firstly, the research and development of quantum cascade lasers with terahertz wide spectrum and frequency band switching, and then the optical path coupling between terahertz quantum cascade lasers and near-field microscopes, and then It is based on t...

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Abstract

The invention provides a near-field microscopy system and a construction method thereof. The near-field microscopy system comprises an infrared / terahertz laser, a light path coupling module and an atomic force microscope. Accurate imaging and spectrum formation can carried out on morphology, physicochemical and molecular characteristics of a sample under a sub-wavelength scale. According to the photo-induced thermal expansion effect of infrared / terahertz dual-band adjustable radiation, thermal expansion deformation of the material is associated with infrared / terahertz characteristic absorption, and structural property information of the material is directly extracted through an atomic force probe. According to the invention, an infrared / terahertz optical detector does not need to be arranged at the far end, thereby avoiding violent signal attenuation caused by long-distance transmission; a reference light path does not need to be arranged, and the repeatability and reliability of material sub-wavelength structure information detection can be remarkably enhanced; meanwhile, the system has the advantages of being high in imaging speed, completely harmless to organisms, high in resolution ratio, capable of achieving multi-mode synchronous output and the like, and good complementation with existing existing mainstream medical imaging means is realized.

Description

technical field [0001] The invention relates to the technical field of biomedical detection, in particular to a near-field microscopic system and its construction method. Background technique [0002] With the invention of THz-TDS (terahertz time-domain spectroscopy) and its popularization in recent years, many unique properties of electromagnetic waves in the terahertz frequency band have been gradually discovered. The vibration and rotation frequencies of many biological and chemical macromolecules are located in the THz band. Thus set off a research boom based on THz-TDS spectral imaging technology. THz-TDS collects the spectral characteristics of matter in the THz frequency band, which enables us to have a clear understanding of the electromagnetic response of matter in the THz frequency band, which is also the basis for further terahertz work. [0003] The above two mainstream terahertz technical means for physical property or structural characterization have begun to ...

Claims

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Application Information

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IPC IPC(8): G01N21/3586
CPCG01N21/3586
Inventor 陶虎姜建娟周志涛黎华
Owner SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
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