A kind of preparation method of guanidine chitosan quaternary ammonium antibacterial agent

Abstract

The invention discloses a preparation method of a guanidine-chitosan quaternary ammonium salt antibacterial agent. The chitosan quaternary ammonium salt is prepared by reacting chitosan and glycidyltrimethylammonium chloride, and then the chitosan is prepared The quaternary ammonium salt reacts with polyaminopropyl biguanide substituted dichloro-s-triazine, and ultrafiltration and concentration can obtain the guanidino chitosan quaternary ammonium antibacterial agent. The water solubility of the guanidino-chitosan quaternary ammonium salt antibacterial agent synthesized by the preparation method of the present invention is good, and the pH value and antibacterial activity are high, which are higher than chitosan chitosan and chitosan quaternary ammonium salt. The preparation method is simple, The source of raw materials is convenient, and it is easy for industrialized production.

Description

technical field [0001] The invention belongs to the field of preparation of chitosan antibacterial agents, in particular to a preparation method of guanidine chitosan quaternary ammonium salt antibacterial agents. Background technique [0002] Antimicrobial agents are chemical substances that can keep the growth or reproduction of certain microorganisms below the necessary level for a certain period of time. At present, common antibacterial agents include natural polymer antibacterial agents (such as chitosan and its derivatives), inorganic antibacterial agents (metal ions such as silver and copper), and organic small molecule antibacterial agents (quaternary ammonium salts, halide compounds, etc.) . Among them, inorganic antibacterial agents have the characteristics of high-efficiency antibacterial, but they are expensive and have the risk of heavy metal pollution. Organic small molecule antibacterial agents have the characteristics of rapid sterilization, but poor heat r...

AI Technical Summary

Problems solved by technology

Chitosan has broad-spectrum antibacterial properties, but the antibacterial properties of pure chitosan are not significant, and the solubility is limited. The research on the antibacterial properties of modified chitosan has made significant progress

At present, chitosan antibacterial agents are still mainly in the experimental stage, and the common chitosan quaternary ammonium salt antibacterial agents have disadvantages such as unsatisfactory bactericidal effect, high production cost, and cumbersome production process, and few can be applied to industrial production.

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