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Triamcinolone acetonide-econazole compound cream and preparation method thereof

A technology of Deeconazole Compound Cream and Econazole Nitrate, applied in the field of medicine, can solve the problems of drug precipitation, low solubility, short shelf life and the like, and achieves the effects of good stability, simple preparation method and convenient production and industrialization.

Pending Publication Date: 2020-04-28
Yung Shin Pharm Ind (Kunshan) Co Ltd
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because of the low solubility of triamcinolone acetonide and econazole nitrate in water, the existing triamcinolone acetonide compound cream is prone to drug precipitation and has a short shelf life.

Method used

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  • Triamcinolone acetonide-econazole compound cream and preparation method thereof
  • Triamcinolone acetonide-econazole compound cream and preparation method thereof

Examples

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preparation example Construction

[0025] A preparation method of triamcinolone acetonide econazole compound cream, the steps are as follows:

[0026] Step 1: Weigh the formulated amount of petrolatum, cetyl alcohol, mineral oil, simethicone, spar and econazole nitrate in the reaction kettle, heat to dissolve and stir evenly to obtain mixture 1, wherein the heating temperature is 60°C- 80°C;

[0027] Step 2: Weigh the formulated amount of Tween and purified water and part of the propylene glycol, heat and dissolve, and stir evenly to obtain the mixture 2, wherein the heating temperature is 60°C-80°C;

[0028] Step 3: After weighing the triamcinolone acetonide in the formula and the remaining propylene glycol and mixing evenly, and then sieving through a 100-200 mesh sieve, mixture 3 is obtained;

[0029] Step 4: Mix mixture 1 and mixture 2 evenly to obtain mixture 4. The stirring time is 20-30 minutes, and cool to 40-55°C, then add the prescribed amount of preservative and the mixture 4 into the mixture 3, mix...

Embodiment 1

[0032] Formula: prepared according to the following parts by weight: 1 part of triamcinolone acetonide, 10 parts of econazole nitrate, 95 parts of white petrolatum, 75 parts of cetyl alcohol, 82 parts of mineral oil, 8 parts of simethicone, 16 parts of Span 60, spit 62 parts of temperature 60, 1 part of ethyl p-hydroxybenzoate, 125 parts of propylene glycol and 525 parts of purified water;

[0033] Preparation:

[0034] Step 1: Weigh the formulated amount of petrolatum, cetyl alcohol, mineral oil, simethicone, Span 60 and econazole nitrate in the reaction kettle, heat to dissolve and stir evenly to obtain mixture 1, wherein the heating temperature is 70°C ;

[0035] Step 2: Weigh Tween 60, purified water and part of the propylene glycol in the formula to dissolve immediately, and stir to obtain mixture 2, wherein the heating temperature is 70°C;

[0036] Step 3: After weighing the triamcinolone acetonide of the formula and the remaining propylene glycol and mixing evenly, an...

Embodiment 2

[0039] Formula: prepared according to the following parts by weight: 1 part of triamcinolone acetonide, 10 parts of econazole nitrate, 100 parts of white petrolatum, 80 parts of cetyl alcohol, 80 parts of mineral oil, 10 parts of simethicone, 20 parts of Span 80, spit 60 parts of temperature 80, 2 parts of propyl paraben, 130 parts of propylene glycol and 520 parts of purified water;

[0040] Preparation:

[0041] Step 1: Weigh Vaseline, Cetyl Alcohol, Mineral Oil, Simethicone, Span 80 and Econazole Nitrate in the reaction kettle, heat to dissolve and stir evenly to obtain Mixture 1, where the heating temperature is 60°C ;

[0042]Step 2: Weigh Tween 60, purified water and part of the propylene glycol in the formula to dissolve immediately, and stir to obtain mixture 2, wherein the heating temperature is 60°C;

[0043] Step 3: After weighing the triamcinolone acetonide in the formula and the remaining propylene glycol, mix them evenly, and then sieve through a 100-mesh sieve...

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Abstract

The invention relates to triamcinolone acetonide-econazole compound cream. The compound cream includes, by weight, 1 part of triamcinolone acetonide, 10 parts of econazole nitrate, 95-105 parts of white vaseline, 75-85 parts of cetyl alcohol, 75-85 parts of mineral oil, 8-12 parts of dimeticone, 190-222 parts of an emulsifying agent, 1-5 parts of a preservative and 515-525 parts of purified water;the emulsifying agent is a mixture of span, tween and propylene glycol; and the mixture includes, by weight, 16-22 parts of the span, 50-65 parts of the tween and 125-135 parts of the propylene glycol. The used supplementary materials, such as lubricants, thickening agents, humectants and emulsifying agents, are easy to obtain and non-irritating; and the quality of a product can be guaranteed bytaking propylparaben as the preservative.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a triamcinolone acetonide-econazole compound cream and a preparation method thereof. Background technique [0002] Dermatomycosis is the abbreviation of a large class of skin diseases caused by fungi that infect the skin, mucous membranes and adnexa. This disease belongs to common disease, frequently-occurring disease, and crowd prevalence rate can be as high as more than 20% in hot and humid area. There are many kinds of pathogenic bacteria that cause skin fungal infections. For heterosexual antigens, the body often produces more obvious allergic reactions to pathogenic fungi that invade the skin. Clinically, it can be manifested as eczema dermatitis-like appearance, itching, ringworm rash, and severe secondary bacterial infection. [0003] The active ingredients in triamcinolone acetonide compound cream are triamcinolone acetonide and econazole nitrate. Econazole nitrate i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/58A61K9/06A61K47/14A61P17/00A61P31/02A61P31/10A61K31/4375
CPCA61K31/4375A61K9/06A61K9/0014A61K47/14A61P17/00A61P31/10A61P31/02A61K31/58A61K2300/00
Inventor 刘佳王涛萧嘉伟许姣姣王清平吴苗李芳全
Owner Yung Shin Pharm Ind (Kunshan) Co Ltd
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