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Methacrylic acid sericin/chitosan quaternary ammonium salt hydrogel as well as preparation method and application thereof

A technology of methacrylic acid sericin and chitosan quaternary ammonium salt, applied in medical science, bandages, etc., can solve problems such as limited application, reduce the number of bacteria and the level of inflammation, good antibacterial properties and biocompatibility, The effect of excellent biodegradation and mechanical properties

Inactive Publication Date: 2020-05-19
海南卓瑞生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, chitosan is insoluble in neutral and alkaline aqueous solutions with pH greater than 6.5, which greatly limits its application.

Method used

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  • Methacrylic acid sericin/chitosan quaternary ammonium salt hydrogel as well as preparation method and application thereof
  • Methacrylic acid sericin/chitosan quaternary ammonium salt hydrogel as well as preparation method and application thereof
  • Methacrylic acid sericin/chitosan quaternary ammonium salt hydrogel as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1: the preparation of chitosan quaternary ammonium salt (N-HACC)

[0040] Weigh 3g of chitosan powder and disperse in 15mL of pure water and 5mL of ethanol, put the mixed solution into a three-necked flask and preheat it to 60°C, add 10mL of 30%wt 3-chloro-2-hydroxypropyl Trimethylammonium chloride (GTMAC) aqueous solution, adjust the pH to 7.0 with NaOH, react at 60°C for 5h, pour the mixture into cold acetone, stir and wash in an ice bath at 4°C overnight, and then wash repeatedly with cold acetone Twice, dialyze in pure water with 8000-12000Da dialysis bags, freeze and dry at -50°C to obtain chitosan quaternary ammonium salt product N-HACC, and its quaternization degree is 98.1%.

Embodiment 2

[0041] Embodiment 2: the preparation of sericin (Ser)

[0042] Cut 5g silkworm cocoons into pieces, wash them with pure water, and then put them into an oven for drying. Add the dried cocoons to 200 mL of boiled 0.02M Na 2 CO 3 In the solution, after boiling for 1.5 hours, remove the silkworm cocoons and drain, and centrifuge the solution at a speed of 3500 rpm for 10 minutes with a centrifuge. After filtering the supernatant solution, dialyze it with a dialysis bag with a molecular weight cut-off of 3500 Da for 3 days. Freeze at -50°C and dry to obtain sericin powder.

Embodiment 3

[0043] Embodiment 3: the preparation of methacrylic acid modified sericin (SerMA)

[0044] Dissolve 1 g of Ser prepared in Example 2 in 20 mL of PBS solution with pH=7.4, weigh 0.786 g of methacrylic anhydride, and dissolve it in 10 mL of PBS solution with pH=7.4; The acrylic anhydride solution was slowly dropped into the Ser solution, and reacted for 10 hours; after the reaction was completed, the solution was dialyzed for 3 days with a dialysis bag with a molecular weight cut-off of 3500 Da, and after the dialysis, the solution was frozen at -50°C and dried to obtain SerMA.

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Abstract

The invention discloses methacrylic acid sericin / chitosan quaternary ammonium salt hydrogel as well as a preparation method and an application thereof. The hydrogel comprises methacrylic acid modifiedsericin and chitosan quaternary ammonium salt in the mass ratio being (8-12):(1.5-3). The methacrylic acid sericin / chitosan quaternary ammonium salt hydrogel is synthesized from methacrylic acid modified sericin and chitosan quaternary ammonium salt under the condition of ultraviolet irradiation. The hydrogel has stable rheological property, good decomposition capability, biocompatibility and inherent antibacterial property, can effectively promote the wound healing process and has huge application prospects in skin wound healing dressing.

Description

technical field [0001] The invention relates to the technical field of medical biomaterials, in particular to a methacrylic acid sericin / chitosan quaternary ammonium hydrogel and a preparation method and application thereof. Background technique [0002] The skin is an important organ with a complex structure, including the epidermis and dermis, and has many important protective functions, such as blocking ultraviolet rays, preventing harmful microorganisms from invading, reducing body fluid evaporation, etc., but it is vulnerable to acute trauma, Chronic ulcers and diabetic damage, millions of people suffer from skin wounds that cannot repair themselves every year, resulting in significant medical costs. Severe skin trauma, especially full-thickness injuries involving the epidermis, dermis, appendages (sweat glands, sebaceous glands, and hair follicles), and subcutaneous tissue damage, often results in the formation of nonfunctional scars. Scars are predominantly formed fr...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0023A61L26/0057A61L26/0061A61L26/008A61L26/009C08L5/08
Inventor 马小平陈华奇
Owner 海南卓瑞生物医药有限公司
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