Compound and method for synthesizing 8-hydroxy-2,2,14,14-tetramethyl pentadecanedioic acid by adopting compound

A technology of tetramethylpentadecane and compounds, which is applied in the field of chemical synthesis, can solve problems such as difficulty in guaranteeing product quality and impracticability, and achieve the effect of short steps and mild conditions
CN111170855AActive Publication Date: 2020-05-19AURISCO PHARM(TIANJIN) INC +2
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
AURISCO PHARM(TIANJIN) INC
Publication Date
2020-05-19

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Abstract

The invention belongs to the field of chemical synthesis, and relates to a compound with a structural formula as described in the specification. In the structural formula, R1, R2 and R3 are independently selected from C1-C6 alkyl groups, alkenyl groups and cycloalkyl groups respectively. The invention also provides a method for synthesizing 8-hydroxy-2,2,14,14-tetramethyl pentadecanedioic acid byusing the compound. The method has the advantages of short reaction steps, simplified operation and greatly reduced production cost; and the use of raw materials with high toxicity and danger is avoided, so the method is safer.
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Description

technical field

[0001] The invention belongs to the field of chemical synthesis, and relates to a compound and a method for synthesizing 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid. Background technique

[0002] 8-Hydroxy-2,2,14,14-tetramethylpentadecanedioic acid (Bempedoic Acid), also known as ETC-1002, has the following structural formula:

[0003]

[0004] Bempedoic Acid, developed by Esperion Therapeutic Inc, is a novel inhibitor of ATP citrate lyase (ACL), which can reduce cholesterol biosynthesis and lower LDL-C levels by upregulating LDL receptors, and can be used to treat dyslipidemia and reduce the risk of other cardiovascular diseases. Compared with the currently widely used statins in clinical practice, the advantage of Bempedoic Acid is that it is better tolerated, and it can be used in combination with statins for the treatment of LDL-C that cannot be suppressed by existing methods.

[0005] WO2004067489 reports that the synthetic route of Bempedo...

Claims

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