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Polyether ether ketone-based artificial bone composite material and preparation method thereof

A technology of polyether ether ketone and composite materials, which is applied in the direction of pharmaceutical formulations, prostheses, coatings, etc., can solve the problems of poor mechanical properties and wear resistance, and cannot be used as artificial bone materials, so as to improve interface adhesion, Improved agglomeration and high wear resistance

Active Publication Date: 2020-05-22
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional hydroxyapatite / polyether ether ketone composites are mostly made by blending injection molding, and their mechanical properties and wear resistance are poor, so they cannot be used as artificial bone materials

Method used

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  • Polyether ether ketone-based artificial bone composite material and preparation method thereof
  • Polyether ether ketone-based artificial bone composite material and preparation method thereof
  • Polyether ether ketone-based artificial bone composite material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Step 1: Weigh 10 grams of dry hydroxyapatite powder into a reaction bottle, add 40ml of absolute ethanol and 40ml of deionized water to the bottle, then slowly add 1ml of coupling agent KH550, and keep it at room temperature under nitrogen protection Stir for 20 minutes. Then reflux for 4.5 hours. After reflux, use a sand core funnel and an organic filter to filter, wash repeatedly with absolute ethanol, place in an oven at 80°C for drying treatment, take it out and grind it into a fine powder to obtain modified hydroxyapatite powder.

[0031] figure 1 The infrared spectrograms of the modified hydroxyapatite and hydroxyapatite prepared in Example 1 above are given. Among them, curve 1 is hydroxyapatite, and curve 2 is modified hydroxyapatite. It can be seen that in curve 2, 1730cm -1 The absorption peak of carbon-hydrogen bond appears at 2915cm -1 The absorption peaks of methyl and methylene appear at the place, because the product has been washed many times with a...

Embodiment 2

[0036] Weigh 0.3 g of sulfonated polyether ether ketone into a sample bottle, add 2.5 ml of dimethyl sulfoxide to fully dissolve the sulfonated polyether ether ketone, then add 0.15 g of modified hydroxyapatite powder, and stir at room temperature After 4-6 hours, put it into an ultrasonic machine for ultrasonication for 1-2 hours to make it fully mixed.

[0037] Place the surface-treated polyether ether ketone plate in a horizontal oven, and pour the evenly stirred mixture on the polyether ether ketone plate through a filter cloth by laying a film, set the oven to 80-120°C, and Dry for 12 hours to obtain a sulfonated polyether ether ketone / modified hydroxyapatite / polyether ether ketone composite material.

Embodiment 3

[0039] 0.3 g of sulfonated polyether ether ketone was weighed and placed in a sample bottle, and 2.5 ml of dimethyl sulfoxide was added to fully dissolve the sulfonated polyether ether ketone. Then add 0.3 g of modified hydroxyapatite powder, stir at room temperature for 4-6 hours, and then put it into an ultrasonic instrument for 1-2 hours to make it fully mixed.

[0040]Place the surface-treated polyether ether ketone plate in a horizontal oven, and pour the evenly stirred mixture on the polyether ether ketone plate through a filter cloth by laying a film, set the oven to 80-120°C, and Dry for 12 hours to obtain a sulfonated polyether ether ketone / modified hydroxyapatite / polyether ether ketone composite material.

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Abstract

The invention provides a polyether ether ketone-based artificial bone composite material. The composite material is formed by compounding a polyether ether ketone substrate with a modified hydroxyapatite and sulfonated polyether ether ketone mixture layer coated on the substrate, wherein the mass ratio of sulfonated polyether ether ketone to modified hydroxyapatite is 1:(0.5-1.5). Hydroxyapatite is modified to form a chemical adsorption layer on the surface, so that contact among particles is prevented, and the agglomeration phenomenon of the nanoparticles is improved; secondly, the sulfonatedpolyether ether ketone is added, so that the adhesion between the modified hydroxyapatite and the substrate material is enhanced; and in addition, acid etching is performed on the surface of the substrate material, so that an acting force can be produced between the substrate material and the sulfonated polyether ether ketone to further improve the interface adhesion. The composite material obtained by the method has the advantages of high thermal performance and high wear resistance, and can be used as a novel artificial bone material.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, in particular to an artificial bone composite material based on polyether ether ketone. Background technique [0002] With the continuous development of biomaterials, more and more composite materials with excellent properties are applied to artificial joint replacement. Polymer-based composite materials not only have excellent properties such as wear resistance and biocompatibility, but also have a simple preparation process. , easy to process, so the application prospects of composite materials are becoming more and more extensive, among which polyether ether ketone composite materials are the most concerned. Polyether ether ketone is a semi-crystalline aromatic thermoplastic engineering material with a regular molecular structure and molecular chains containing benzene rings, ether bonds, and carboxyl groups, so it has high rigidity, toughness, and intermolecular forces. Polyether ether ...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/32A61L27/18C08G8/28
CPCA61L27/18A61L27/32A61L27/34A61L2400/18A61L2420/02A61L2420/06A61L2430/02C08G8/28C08L61/16
Inventor 江东张煜晗杨延华郭易乔谭皓元
Owner JILIN UNIV
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