Organic metal drug camptothecin-ferrocene and preparation method thereof

An organometallic and camptothecin technology, applied in the field of organometallic drug camptothecin-ferrocene and its preparation, can solve the problems of cumbersome preparation methods and low yield of derivatives, and achieve the effect of simple preparation process
CN111187305APending Publication Date: 2020-05-22NORTHWESTERN POLYTECHNICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NORTHWESTERN POLYTECHNICAL UNIV
Publication Date
2020-05-22

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Abstract

The invention relates to an organic metal drug camptothecin-ferrocene and a preparation method thereof, wherein an anticancer natural product camptothecin is used as a raw material, and is combined with ferrocene with anticancer activity to synthesize a novel camptothecin-ferrocene derivative. According to the camptothecin-ferrocene derivative, camptothecin and ferrocene have a good killing effecton cancer cells at the same time, and the combined product can play a role in jointly killing the cancer cells. According to the invention, a natural product medicine camptothecin and ferrocene withanti-cancer activity react to generate the camptothecin derivative with ferrocene at the tail end, and the produced camptothecin-ferrocene derivative combines camptothecin and ferrocene, has a good killing effect on cancer cells, and has a combined anti-cancer effect; and the method is simple in preparation process, and a new thought and method are provided for research and development of novel anti-cancer drugs.
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Description

technical field

[0001] The invention belongs to the field of material synthesis and relates to a preparation method of an organometallic drug, in particular to an organometallic drug camptothecin-ferrocene and a preparation method thereof. Background technique

[0002] Camptothecin is a natural product anticancer drug, which is isolated and purified from camptothecin. Belonging to the cytotoxic quinoline alkaloids, it can effectively inhibit DNA topoisomerase. Studies have found that camptothecin has a good therapeutic effect on human gastrointestinal tract and head and neck cancer, and has fewer side effects. On the other hand, studies have found that ferrocene has good anticancer activity because it is prone to redox reactions in cells.

[0003] Document 1 "Fuwu Zhang, Longjiang Zhang, Guizhi Zhu, and Xiaoyuan Chen et al. Polymeric Nanoparticles with a Glutathione-Sensitive Heterodimeric Multifunctional Prodrug for In Vivo Drug Monitoring and Synergistic Cancer Therapy [...

Claims

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